Twins vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 2:12 a.m.

Tuesday's slate in the MLB includes a matchup between the Minnesota Twins and the Washington Nationals.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Nationals Game Info

• Minnesota Twins (15-20) vs. Washington Nationals (16-19)
• Date: Tuesday, May 5, 2026
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and Twins.TV

Twins vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-110) | WSH: (-106)
• Spread: MIN: -1.5 (+134) | WSH: +1.5 (-162)
• Total: 9 -- Over: (-104) | Under: (-118)

Twins vs Nationals Probable Starting Pitchers

Probable Pitchers: Taj Bradley (Twins) - 3-1, 2.85 ERA vs Cade Cavalli (Nationals) - 1-1, 3.82 ERA

The Twins will give the ball to Taj Bradley (3-1, 2.85 ERA), who is eyeing win No. 4 on the season, and the Nationals will turn to Cade Cavalli (1-1, 3.82 ERA). Bradley and his team have a record of 4-3-0 against the spread when he starts. Bradley's team lost his only start as a favorite this season. When Cavalli starts, the Nationals have gone 5-2-0 against the spread. The Nationals have been the moneyline underdog in six of Cavalli's starts this season, and they went 2-4 in those matchups.

Twins vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (55.3%)

Twins vs Nationals Moneyline

• Looking at the moneyline for Twins-Nationals, Minnesota is the favorite at -110, and Washington is -106 playing at home.

Twins vs Nationals Spread

• The Nationals are at +1.5 on the runline against the Twins. The Nationals are -162 to cover the spread, and the Twins are +134.

Twins vs Nationals Over/Under

• Twins versus Nationals on May 5 has an over/under of 9 runs, with the odds on the over -104 and the under set at -118.

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Twins vs Nationals Betting Trends

• The Twins have been favorites in nine games this season and have come away with the win three times (33.3%) in those contests.
• Minnesota has a record of 3-6 when favored by -110 or more this year.
• Contests with the Twins have gone over the total set by oddsmakers in 21 of 35 chances this season.
• The Twins have posted a record of 17-18-0 against the spread this season.
• The Nationals are 16-18 in games they were listed as the moneyline underdog (winning 47.1% of those games).
• When playing as a moneyline underdog with odds of -106 or longer, Washington has gone 16-18 (47.1%).
• The Nationals have combined with opponents to hit the over on the total 21 times this season for a 21-12-2 record against the over/under.
• The Nationals have a 19-16-0 record ATS this season (covering 54.3% of the time).

Twins Player Leaders

• Byron Buxton leads Minnesota in OBP (.313), slugging percentage (.530) and total hits (34) this season. He has a .254 batting average.
• Among all qualified hitters in baseball, he is 82nd in batting average, 119th in on-base percentage, and 22nd in slugging.
• Ryan Jeffers is batting .287 with two doubles, a triple, four home runs and 15 walks. He's slugging .471 with an on-base percentage of .394.
• Josh Bell has collected 26 base hits, an OBP of .304 and a slugging percentage of .336 this season.
• Brooks Lee is batting .255 with a .311 OBP and 18 RBI for Minnesota this season.
• Lee brings a three-game hitting streak into this game. During his last five outings he is hitting .316 with three RBIs.

Nationals Player Leaders

• C.J. Abrams has totaled 35 hits with a .406 on-base percentage and a .534 slugging percentage, all club-bests for the Nationals. He's batting .297.
• Including all the qualifying players in MLB, his batting average ranks 30th, his on-base percentage is 13th, and he is 19th in slugging.
• James Wood is batting .231 with seven doubles, 10 home runs and 31 walks. He's slugging .507 with an on-base percentage of .383.
• His batting average is 116th among all qualified players, his on-base percentage ranks 24th, and he is 27th in slugging.
• Daylen Lile has eight doubles, three home runs and 13 walks while hitting .246.
• Nasim Nunez has a double and 14 walks while hitting .222.

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