Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 2:11 a.m.

The Tuesday schedule in MLB includes a matchup between the Chicago Cubs and the Cincinnati Reds.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Reds Game Info

• Chicago Cubs (23-12) vs. Cincinnati Reds (20-15)
• Date: Tuesday, May 5, 2026
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Reds.TV

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-215) | CIN: (+180)
• Spread: CHC: -1.5 (-118) | CIN: +1.5 (-102)
• Total: 11.5 -- Over: (-110) | Under: (-110)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 2-1, 4.41 ERA vs Andrew Abbott (Reds) - 1-2, 5.97 ERA

The probable starters are Jameson Taillon (2-1) for the Cubs and Andrew Abbott (1-2) for the Reds. When Taillon starts, his team is 2-4-0 against the spread this season. Taillon's team has a record of 2-1 this season when he starts and they are the favorite on the moneyline. The Reds have a 4-3-0 ATS record in Abbott's seven starts with a set spread. The Reds are 3-2 in Abbott's five starts this season that they were the moneyline underdog.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (60.7%)

Cubs vs Reds Moneyline

• Chicago is a -215 favorite on the moneyline, while Cincinnati is a +180 underdog on the road.

Cubs vs Reds Spread

• The Cubs are hosting the Reds and are favored by 1.5 runs on the spread. The Cubs are -118 to cover the runline, with the Reds being -102.

Cubs vs Reds Over/Under

• Cubs versus Reds, on May 5, has an over/under of 11.5, with the over being -110 and the under -110.

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Cubs vs Reds Betting Trends

• The Cubs have come away with 15 wins in the 22 contests they have been listed as the favorites in this season.
• Chicago has been listed as a favorite of -215 or more on two occasions this season and split those games.
• The Cubs and their opponents have hit the over in 22 of their 34 games with a total set by oddsmakers this season.
• In 34 games with a line this season, the Cubs have a mark of 17-17-0 against the spread.
• The Reds have compiled a 14-8 record in games they were listed as the moneyline underdog (winning 63.6% of those games).
• Cincinnati has not played a game this season with moneyline odds of +180 or longer.
• In the 33 games bookmakers have set an over/under for the Reds, they have combined with opponents to go over the total 20 times (20-12-1).
• The Reds have a 20-13-0 record against the spread this season.

Cubs Player Leaders

• Nico Hoerner leads Chicago in slugging percentage (.460) thanks to 14 extra-base hits. He has a .299 batting average and an on-base percentage of .369.
• Among all qualifying hitters in baseball, his batting average ranks 28th, his on-base percentage ranks 40th, and he is 48th in slugging.
• Hoerner has hit safely in five straight games. During his last five outings he is hitting .316 with three doubles and three RBIs.
• Dansby Swanson is batting .205 with two doubles, a triple, six home runs and 21 walks, while slugging .402 with an on-base percentage of .328.
• Among all qualifying players, he ranks 158th in batting average, 87th in on-base percentage and 90th in slugging percentage.
• Ian Happ leads his team in OBP (.377) and total hits (30) this season.
• Moises Ballesteros has been key for Chicago with 26 hits, an OBP of .375 plus a slugging percentage of .576.

Reds Player Leaders

• Sal Stewart has six doubles, nine home runs and 18 walks while hitting .252. He's slugging .504 with an on-base percentage of .338.
• Including all the qualified hitters in MLB, his batting average is 83rd, his on-base percentage ranks 75th, and he is 28th in slugging.
• Elly De La Cruz has racked up 39 hits with a .364 on-base percentage while slugging .547. Those stats all pace his team. He also has a batting average of .285.
• He is currently 39th in batting average, 45th in on-base percentage and 14th in slugging percentage among all qualified hitters.
• Nathaniel Lowe has five doubles, five home runs and eight walks while hitting .262.
• Spencer Steer is hitting .255 with six doubles, five home runs and 10 walks.

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