Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 7:11 p.m.

Tuesday's slate in the MLB includes a matchup between the Chicago Cubs and the Cincinnati Reds.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Reds Game Info

• Chicago Cubs (23-12) vs. Cincinnati Reds (20-15)
• Date: Tuesday, May 5, 2026
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Reds.TV

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-215) | CIN: (+180)
• Spread: CHC: -1.5 (-118) | CIN: +1.5 (-102)
• Total: 11.5 -- Over: (-110) | Under: (-110)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 2-1, 4.41 ERA vs Andrew Abbott (Reds) - 1-2, 5.97 ERA

The Cubs will look to Jameson Taillon (2-1) against the Reds and Andrew Abbott (1-2). Taillon's team is 2-4-0 against the spread in his starts this season. When Taillon starts a game and his team is the favorite on the moneyline, they have a record of 2-1. When Abbott starts, the Reds are 4-3-0 against the spread. The Reds have a 3-2 record in Abbott's five starts this season when they were the moneyline underdog.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (60.1%)

Cubs vs Reds Moneyline

• Looking at the moneyline for Cubs-Reds, Chicago is the favorite at -215, and Cincinnati is +180 playing on the road.

Cubs vs Reds Spread

• The Reds are +1.5 on the spread (-102 to cover), and Chicago is -118 to cover the runline.

Cubs vs Reds Over/Under

• Cubs versus Reds, on May 5, has an over/under of 11.5, with the over being -110 and the under -110.

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Cubs vs Reds Betting Trends

• The Cubs have been victorious in 15, or 68.2%, of the 22 contests they have been chosen as favorites in this season.
• Chicago has been listed as a favorite of -215 or more on two occasions this season and split those games.
• The Cubs and their opponents have gone over in 22 of their 34 games with a total set by sportsbooks this season.
• In 34 games with a line this season, the Cubs have a mark of 17-17-0 against the spread.
• The Reds have been the moneyline underdog 22 total times this season. They've finished 14-8 in those games.
• Cincinnati has never played a game this season with moneyline odds of +180 or longer.
• The Reds have played in 33 games with an over/under set, and have combined with their opponents to go over the total 20 times (20-12-1).
• The Reds have covered 60.6% of their games this season, going 20-13-0 ATS.

Cubs Player Leaders

• Nico Hoerner has an OPS of .829, fueled by an OBP of .369 and a team-best slugging percentage of .460 this season. He has a .299 batting average.
• He is 28th in batting average, 40th in on-base percentage, and 48th in slugging among all qualified hitters in MLB.
• Hoerner has hit safely in five straight games. In his last five games he is batting .316 with three doubles and three RBIs.
• Dansby Swanson is hitting .205 with two doubles, a triple, six home runs and 21 walks, while slugging .402 with an on-base percentage of .328.
• He is 158th in batting average, 87th in on-base percentage and 90th in slugging among qualified hitters.
• Ian Happ has 30 hits and an OBP of .377, both of which lead the Cubs this season.
• Moises Ballesteros has six home runs, 18 RBI and a batting average of .306 this season.

Reds Player Leaders

• Sal Stewart has six doubles, nine home runs and 18 walks while hitting .252. He's slugging .504 with an on-base percentage of .338.
• Including all qualifying players, he is 83rd in batting average, while his on-base percentage ranks 75th and he is 28th in slugging.
• Elly De La Cruz has racked up 39 hits with a .364 OBP while slugging .547. Those stats all pace his team. He also has a batting average of .285.
• Including all qualifying hitters, his batting average places him 39th, his on-base percentage is 45th, and he is 14th in slugging.
• Spencer Steer has six doubles, five home runs and 10 walks while hitting .255.
• Nathaniel Lowe is batting .262 with five doubles, five home runs and eight walks.

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