Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 2:11 a.m.

MLB action on Tuesday includes the Cleveland Guardians facing the Kansas City Royals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Royals Game Info

• Cleveland Guardians (18-18) vs. Kansas City Royals (16-19)
• Date: Tuesday, May 5, 2026
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CleGuardians.TV

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | KC: (+100)
• Spread: CLE: -1.5 (+142) | KC: +1.5 (-172)
• Total: 8 -- Over: (-105) | Under: (-115)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 5-1, 2.70 ERA vs Stephen Kolek (Royals) - 0-0, 0.00 ERA

The probable starters are Gavin Williams (5-1) for the Guardians and Stephen Kolek for the Royals. Williams and his team are 5-1-0 ATS this season when he starts. Williams and his team have won each of the four games he's started as the moneyline favorite. Last season in games Kolek pitched his team finished 12-7-0 against the spread. Kolek and his team finished with a 4-7 record in the 11 games he pitched when they were moneyline underdogs a season ago.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (52.4%)

Guardians vs Royals Moneyline

• The Guardians vs Royals moneyline has Cleveland as a -118 favorite, while Kansas City is a +100 underdog at home.

Guardians vs Royals Spread

• The Royals are at +1.5 on the runline against the Guardians. The Royals are -172 to cover the spread, and the Guardians are +142.

Guardians vs Royals Over/Under

• Guardians versus Royals, on May 5, has an over/under of 8, with the over being -105 and the under -115.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have won in eight, or 50%, of the 16 contests they have been named as odds-on favorites in this year.
• Cleveland has a record of 7-8 when favored by -118 or more this year.
• The Guardians' games have gone over the total in 17 of their 35 opportunities.
• The Guardians are 18-17-0 against the spread in their 35 games with a line set by sportsbooks this season.
• The Royals have a 6-11 record in games they were listed as the moneyline underdog (winning 35.3% of those games).
• When it has played as a moneyline underdog with odds of +100 or longer, Kansas City has a 3-9 record (winning only 25% of its games).
• The Royals have played in 33 games with an over/under set, and have combined with opponents to go over the total 13 times (13-20-0).
• The Royals have put together a 16-17-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez is batting .218 with eight doubles, six home runs and 24 walks. He has an on-base percentage of .338 while slugging .414.
• Among qualifying batters, he ranks 136th in batting average, his on-base percentage ranks 75th, and he is 80th in slugging.
• Ramirez has recorded a base hit in three games in a row. During his last five outings he is hitting .200 with two doubles, three walks and two RBIs.
• Chase DeLauter has 34 hits and an OBP of .392 to go with a slugging percentage of .554. All three of those stats rank first among Cleveland hitters this season. He's batting .304.
• Among qualifying batters, his batting average places him 24th, his on-base percentage 18th, and his slugging percentage 12th.
• DeLauter brings an eight-game streak with at least one hit into this contest. During his last 10 games he is batting .486 with three doubles, a home run, five walks and six RBIs.
• Brayan Rocchio is batting .261 with a .374 slugging percentage and 19 RBI this year.
• Angel Martinez has five home runs, 16 RBI and a batting average of .279 this season.
• Martinez has hit safely in two games in a row. In his last five games he is hitting .294 with two doubles, a walk and an RBI.

Royals Player Leaders

• Bobby Witt Jr. has a .354 on-base percentage and a .424 slugging percentage, both team-best numbers for the Royals. He's batting .281.
• Including all the qualifying players in the big leagues, his batting average is 40th, his on-base percentage is 60th, and he is 70th in slugging.
• Witt takes a four-game hitting streak into this game. In his last five games he is batting .190 with a home run, three walks and an RBI.
• Maikel Garcia is batting .262 with nine doubles, a triple, three home runs and 13 walks. He's slugging .415 with an on-base percentage of .324.
• Including all qualified hitters, he is 62nd in batting average, 97th in on-base percentage and 78th in slugging percentage.
• Vinnie Pasquantino has four doubles, two triples, four home runs and 16 walks while batting .198.
• Carter Jensen is hitting .231 with two doubles, six home runs and 13 walks.

Guardians vs Royals Head to Head

• 5/4/2026: 6-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/8/2026: 10-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/7/2026: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/6/2026: 4-2 KC (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/11/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/10/2025: 4-3 KC (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/26/2025: 6-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)

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