Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 7:11 p.m.

The MLB's Tuesday slate includes the Cleveland Guardians facing the Kansas City Royals.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Royals Game Info

• Cleveland Guardians (18-18) vs. Kansas City Royals (16-19)
• Date: Tuesday, May 5, 2026
• Time: 7:40 p.m. ET
• Venue: Kauffman Stadium -- Kansas City, Missouri
• Coverage: Royals.TV and CleGuardians.TV

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | KC: (-102)
• Spread: CLE: -1.5 (+142) | KC: +1.5 (-172)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 5-1, 2.70 ERA vs Stephen Kolek (Royals) - 0-0, 0.00 ERA

The Guardians will look to Gavin Williams (5-1) against the Royals and Stephen Kolek. Williams and his team have a record of 5-1-0 against the spread when he starts. Williams' team has won each of the four games he's started as the moneyline favorite. Last season Kolek and his team went 12-7-0 against the spread when he pitched. Kolek and his team finished with a 4-7 record in the 11 games he pitched when they were the underdog on the moneyline a season ago.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (54.4%)

Guardians vs Royals Moneyline

• Looking at the moneyline for Royals-Guardians, Kansas City is the underdog at -102, and Cleveland is -116 playing on the road.

Guardians vs Royals Spread

• The Guardians are at the Royals and are favored by 1.5 runs on the spread. The Guardians are +142 to cover the runline, with the Royals being -172.

Guardians vs Royals Over/Under

• The over/under for Guardians-Royals on May 5 is 7.5. The over is -106, and the under is -114.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have been chosen as favorites in 16 games this year and have walked away with the win eight times (50%) in those games.
• This year Cleveland has won eight of 16 games when listed as at least -116 on the moneyline.
• The Guardians and their opponents have hit the over in 17 of their 35 games with a total set by oddsmakers this season.
• The Guardians have an against the spread mark of 18-17-0 in 35 games with a line this season.
• The Royals have been the underdog on the moneyline 17 total times this season. They've gone 6-11 in those games.
• When playing as a moneyline underdog with odds of -102 or longer, Kansas City has a record of 4-10 (28.6%).
• The Royals have combined with opponents to go over the total 13 times this season for a 13-20-0 record against the over/under.
• The Royals have a 16-17-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez is batting .218 with eight doubles, six home runs and 24 walks. He has an on-base percentage of .338 and a slugging percentage of .414.
• He ranks 136th in batting average, 75th in on-base percentage, and 80th in slugging among all qualified batters in the majors.
• Ramirez has recorded a base hit in three games in a row. During his last five outings he is batting .200 with two doubles, three walks and two RBIs.
• Chase DeLauter leads Cleveland in OBP (.392), slugging percentage (.554) and total hits (34) this season. He's batting .304.
• His batting average is 24th among qualified players, his on-base percentage 18th, and his slugging percentage 12th.
• DeLauter has picked up a hit in eight straight games. In his last 10 games he is batting .486 with three doubles, a home run, five walks and six RBIs.
• Brayan Rocchio has 30 hits this season and has a slash line of .261/.336/.374.
• Angel Martinez has been key for Cleveland with 29 hits, an OBP of .315 plus a slugging percentage of .490.
• Martinez takes a two-game hitting streak into this game. During his last five outings he is hitting .294 with two doubles, a walk and an RBI.

Royals Player Leaders

• Bobby Witt Jr. has a team-best OBP (.354) and slugging percentage (.424). He's batting .281.
• Including all the qualifying hitters in MLB, he ranks 40th in batting average, 60th in on-base percentage and 70th in slugging percentage.
• Witt hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .190 with a home run, three walks and an RBI.
• Maikel Garcia has nine doubles, a triple, three home runs and 13 walks while hitting .262. He's slugging .415 with an on-base percentage of .324.
• He is currently 62nd in batting average, 97th in on-base percentage and 78th in slugging percentage among all qualifying hitters.
• Vinnie Pasquantino is hitting .198 with four doubles, two triples, four home runs and 16 walks.
• Carter Jensen is batting .231 with two doubles, six home runs and 13 walks.

Guardians vs Royals Head to Head

• 5/4/2026: 6-2 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/8/2026: 10-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/7/2026: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/6/2026: 4-2 KC (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/11/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/10/2025: 4-3 KC (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/26/2025: 6-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)

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