Cardinals vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for May 5

Odds updated as of 2:12 a.m.

The St. Louis Cardinals will take on the Milwaukee Brewers in MLB action on Tuesday.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Brewers Game Info

• St. Louis Cardinals (21-14) vs. Milwaukee Brewers (18-16)
• Date: Tuesday, May 5, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Brewers.TV

Cardinals vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-112) | MIL: (-104)
• Spread: STL: +1.5 (-200) | MIL: -1.5 (+164)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Cardinals vs Brewers Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 3-2, 3.73 ERA vs Brandon Sproat (Brewers) - 0-2, 6.75 ERA

The probable pitchers are Andre Pallante (3-2) for the Cardinals and Brandon Sproat (0-2) for the Brewers. Pallante and his team have a record of 4-2-0 against the spread when he starts. Pallante's team lost his only start as a favorite this season. When Sproat starts, the Brewers are 3-1-0 against the spread. The Brewers were the moneyline underdog for one Sproat start this season -- they lost.

Cardinals vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.8%)

Cardinals vs Brewers Moneyline

• St. Louis is a -112 favorite on the moneyline, while Milwaukee is a -104 underdog on the road.

Cardinals vs Brewers Spread

• The Brewers are 1.5-run favorites against the spread for this matchup with the Cardinals. The Brewers are +164 to cover, while the Cardinals are -200 to cover as a 1.5-run underdog on the runline.

Cardinals vs Brewers Over/Under

• An over/under of 7.5 has been set for Cardinals-Brewers on May 5, with the over being -122 and the under +100.

Bet on St. Louis Cardinals vs. Milwaukee Brewers on FanDuel today!

Cardinals vs Brewers Betting Trends

• The Cardinals have come away with two wins in the three contests they have been listed as the favorites in this season.
• St. Louis has a record of 2-1 when favored by -112 or more this year.
• The Cardinals and their opponents have hit the over in 18 of their 35 games with a total set by oddsmakers this season.
• The Cardinals have an against the spread mark of 22-13-0 in 35 games with a line this season.
• The Brewers have a 4-7 record in games they were the underdog on the moneyline (winning 36.4% of those games).
• Milwaukee is 2-5 (winning only 28.6% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Brewers have combined with opponents to go over the total 17 times this season for a 17-16-1 record against the over/under.
• The Brewers have a 20-14-0 record against the spread this season (covering 58.8% of the time).

Cardinals Player Leaders

• Jordan Walker leads St. Louis with 40 hits and a team-best slugging percentage of .585. He's batting .308 with an on-base percentage of .377.
• He ranks 20th in batting average, 34th in on-base percentage, and seventh in slugging among all qualifying hitters in baseball.
• Alec Burleson is batting .269 with nine doubles, five home runs and 17 walks. He's slugging .448 with an on-base percentage of .349.
• Among qualified batters, he is 55th in batting average, 65th in on-base percentage and 54th in slugging percentage.
• JJ Wetherholt has 33 hits this season and has a slash line of .246/.360/.440.
• Wetherholt heads into this game with two games in a row with at least one hit. During his last five outings he is batting .238 with a home run, two walks and three RBIs.
• Ivan Herrera leads St. Louis in OBP (.416) this season, fueled by 32 hits.

Brewers Player Leaders

• Brice Turang has totaled 35 hits with a .434 on-base percentage, leading the Brewers in both categories. He's batting .304 and slugging .522.
• Including all the qualifying players in the majors, his batting average is 24th, his on-base percentage is third, and he is 23rd in slugging.
• Turang hopes to build on a six-game hitting streak in this matchup. During his last 10 games he is hitting .324 with three doubles, a home run, eight walks and four RBIs.
• William Contreras is slugging .411 to lead his team. He has a batting average of .287 with an on-base percentage of .357.
• He is 38th in batting average, 56th in on-base percentage and 83rd in slugging percentage in MLB.
• Jake Bauers is hitting .248 with six doubles, five home runs and 13 walks.
• Sal Frelick has two doubles, three home runs and 15 walks while hitting .212.

Cardinals vs Brewers Head to Head

• 5/4/2026: 6-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/21/2025: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/20/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!