Twins vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 7:13 p.m.

On Friday in MLB, the Minnesota Twins are playing the Arizona Diamondbacks.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Twins vs Diamondbacks Game Info

• Minnesota Twins (64-82) vs. Arizona Diamondbacks (73-74)
• Date: Friday, September 12, 2025
• Time: 8:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and ARID

Twins vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-136) | ARI: (+116)
• Spread: MIN: -1.5 (+160) | ARI: +1.5 (-194)
• Total: 8.5 -- Over: (+102) | Under: (-124)

Twins vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Pablo Lopez (Twins) - 5-4, 2.83 ERA vs Brandon Pfaadt (Diamondbacks) - 13-8, 5.18 ERA

The Twins will call on Pablo Lopez (5-4) against the Diamondbacks and Brandon Pfaadt (13-8). Lopez's team is 8-4-0 against the spread this season in his starts. Lopez's team has a record of 7-2 this season when he starts and they are the favorite on the moneyline. The Diamondbacks have an 18-11-0 record against the spread in Pfaadt's starts. The Diamondbacks have a 7-7 record in Pfaadt's 14 starts this season when they were the moneyline underdog.

Twins vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (53.7%)

Twins vs Diamondbacks Moneyline

• Minnesota is a -136 favorite on the moneyline, while Arizona is a +116 underdog on the road.

Twins vs Diamondbacks Spread

• The Diamondbacks are at +1.5 on the runline against the Twins. The Diamondbacks are -194 to cover the spread, and the Twins are +160.

Twins vs Diamondbacks Over/Under

• Twins versus Diamondbacks on Sept. 12 has an over/under of 8.5 runs, with the odds on the over +102 and the under set at -124.

Bet on Minnesota Twins vs. Arizona Diamondbacks on FanDuel today!

Twins vs Diamondbacks Betting Trends

• The Twins have been favorites in 83 games this season and have come away with the win 39 times (47%) in those contests.
• This year Minnesota has won 21 of 39 games when listed as at least -136 on the moneyline.
• The Twins and their opponents have hit the over in 67 of their 141 games with a total set by oddsmakers this season.
• The Twins are 69-72-0 against the spread in their 141 games with a line set by sportsbooks this season.
• The Diamondbacks have compiled a 29-31 record in games they were listed as the moneyline underdog (winning 48.3% of those games).
• In games it has played as a moneyline underdog with odds of +116 or longer, Arizona has gone 16-13 (55.2%).
• In the 143 games oddsmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 71 times (71-66-6).
• The Diamondbacks have covered 49% of their games this season, going 70-73-0 against the spread.

Twins Player Leaders

• Byron Buxton leads Minnesota with 117 hits and an OBP of .337 this season. He has a .275 batting average and a slugging percentage of .568.
• Among qualified hitters in MLB, he is 33rd in batting average, 55th in on-base percentage, and fourth in slugging.
• Buxton will look for his fifth straight game with a hit in this matchup. In his last five games he is hitting .313 with a triple, two home runs, a walk and four RBIs.
• Trevor Larnach has an OPS of .736, fueled by an OBP of .328 and a team-best slugging percentage of .409 this season. He's batting .256.
• Among qualifiers, he ranks 82nd in batting average, 77th in on-base percentage and 90th in slugging percentage.
• Brooks Lee has collected 104 base hits, an OBP of .288 and a slugging percentage of .371 this season.
• Royce Lewis has 12 home runs, 44 RBI and a batting average of .231 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has put up a .383 on-base percentage and a .449 slugging percentage, both team-best averages for the Diamondbacks. He's batting .284.
• Including all the qualifying hitters in MLB, he ranks 19th in batting average, sixth in on-base percentage and 61st in slugging percentage.
• Corbin Carroll has 131 hits to pace his team. He has a batting average of .254 while slugging .547 with an on-base percentage of .332.
• He is currently 86th in batting average, 67th in on-base percentage and sixth in slugging percentage among all qualified hitters.
• Ketel Marte has 22 doubles, 25 home runs and 63 walks while batting .281.
• Gabriel Moreno is hitting .286 with 11 doubles, a triple, eight home runs and 19 walks.

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