Twins vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 5:19 a.m.

The MLB's Friday schedule includes the Minnesota Twins taking on the Arizona Diamondbacks.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Twins vs Diamondbacks Game Info

• Minnesota Twins (64-82) vs. Arizona Diamondbacks (73-74)
• Date: Friday, September 12, 2025
• Time: 8:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and ARID

Twins vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-132) | ARI: (+112)
• Spread: MIN: -1.5 (+162) | ARI: +1.5 (-196)
• Total: 8 -- Over: (-122) | Under: (-100)

Twins vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Pablo Lopez (Twins) - 5-4, 2.83 ERA vs Brandon Pfaadt (Diamondbacks) - 13-8, 5.18 ERA

The Twins will call on Pablo Lopez (5-4) against the Diamondbacks and Brandon Pfaadt (13-8). When Lopez starts, his team is 8-4-0 against the spread this season. Lopez's team is 7-2 this season when he starts and they are the moneyline favorite. The Diamondbacks have an 18-11-0 record against the spread in Pfaadt's starts. The Diamondbacks have a 7-7 record in Pfaadt's 14 starts this season when they were the underdog on the moneyline.

Twins vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (53.7%)

Twins vs Diamondbacks Moneyline

• Arizona is a +112 underdog on the moneyline, while Minnesota is a -132 favorite at home.

Twins vs Diamondbacks Spread

• The Diamondbacks are at +1.5 on the runline against the Twins. The Diamondbacks are -196 to cover the spread, and the Twins are +162.

Twins vs Diamondbacks Over/Under

• Twins versus Diamondbacks, on Sept. 12, has an over/under of 8, with the over being -122 and the under -100.

Bet on Minnesota Twins vs. Arizona Diamondbacks on FanDuel today!

Twins vs Diamondbacks Betting Trends

• The Twins have won in 39, or 47%, of the 83 contests they have been named as odds-on favorites in this year.
• This year Minnesota has won 21 of 42 games when listed as at least -132 on the moneyline.
• The Twins and their opponents have gone over in 67 of their 141 games with a total set by sportsbooks this season.
• The Twins have posted a record of 69-72-0 against the spread this season.
• The Diamondbacks have been the underdog on the moneyline 60 total times this season. They've finished 29-31 in those games.
• When playing as a moneyline underdog with odds of +112 or longer, Arizona has a 17-15 record (winning 53.1% of its games).
• In the 143 games oddsmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 71 times (71-66-6).
• The Diamondbacks have covered 49% of their games this season, going 70-73-0 ATS.

Twins Player Leaders

• Byron Buxton leads Minnesota with 117 hits and an OBP of .337 this season. He has a .275 batting average and a slugging percentage of .568.
• He ranks 33rd in batting average, 55th in on-base percentage, and fourth in slugging among qualifying hitters in the majors.
• Buxton will look for his fifth straight game with a hit in this contest. In his last five games he is batting .313 with a triple, two home runs, a walk and four RBIs.
• Trevor Larnach leads Minnesota in slugging percentage (.409) thanks to 38 extra-base hits. He's batting .256 with an on-base percentage of .328.
• He is 82nd in batting average, 77th in on-base percentage and 89th in slugging in the majors.
• Brooks Lee is batting .238 with a .371 slugging percentage and 57 RBI this year.
• Royce Lewis has been key for Minnesota with 73 hits, an OBP of .286 plus a slugging percentage of .396.

Diamondbacks Player Leaders

• Geraldo Perdomo has accumulated a team-high OBP (.383) and slugging percentage (.449). He's batting .284.
• He is 19th in batting average, sixth in on-base percentage and 61st in slugging percentage among all qualified batters in MLB.
• Corbin Carroll's 131 hits lead his team. He has a batting average of .254 while slugging .547 with an on-base percentage of .332.
• Including all qualifying hitters, his batting average puts him 86th, his on-base percentage is 67th, and he is sixth in slugging.
• Ketel Marte is batting .281 with 22 doubles, 25 home runs and 63 walks.
• Gabriel Moreno is batting .286 with 11 doubles, a triple, eight home runs and 19 walks.

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