Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 9:12 p.m.

The MLB slate on Friday includes the San Diego Padres facing the Colorado Rockies.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Padres vs Rockies Game Info

• San Diego Padres (80-67) vs. Colorado Rockies (40-107)
• Date: Friday, September 12, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and COLR

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-270) | COL: (+220)
• Spread: SD: -1.5 (-137) | COL: +1.5 (+114)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: JP Sears (Padres) - 8-10, 5.01 ERA vs Tanner Gordon (Rockies) - 5-6, 6.60 ERA

The probable pitchers are JP Sears (8-10) for the Padres and Tanner Gordon (5-6) for the Rockies. Sears and his team are 13-12-0 ATS this season when he starts. When Sears starts a game and his team is the favorite on the moneyline, they have a record of 4-2. The Rockies are 7-4-0 ATS in Gordon's 11 starts with a set spread. The Rockies have been the underdog on the moneyline in 11 of Gordon's starts this season, and they went 6-5 in those games.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (66.8%)

Padres vs Rockies Moneyline

• San Diego is the favorite, -270 on the moneyline, while Colorado is a +220 underdog on the road.

Padres vs Rockies Spread

• The Rockies are +1.5 on the run line against the Padres. The Rockies are +114 to cover, and the Padres are -137.

Padres vs Rockies Over/Under

• Padres versus Rockies on Sept. 12 has an over/under of 8.5 runs, with the odds on the over -110 and the under set at -110.

Bet on San Diego Padres vs. Colorado Rockies on FanDuel today!

Padres vs Rockies Betting Trends

• The Padres have been victorious in 47, or 59.5%, of the 79 contests they have been chosen as favorites in this season.
• San Diego has been listed as a favorite of -270 or more on two occasions this season and split those games.
• The Padres and their opponents have hit the over in 62 of their 145 games with a total set by oddsmakers this season.
• In 145 games with a line this season, the Padres have a mark of 78-67-0 against the spread.
• The Rockies have won 25.9% of the games this season they were the moneyline underdog (36-103).
• Colorado has a record of 8-38 when playing as a moneyline underdog with odds of +220 or longer (17.4%).
• In the 143 games bookmakers have set an over/under for the Rockies, they have combined with opponents to go over the total 61 times (61-77-5).
• The Rockies have put together a 57-86-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is hitting .260 with 27 doubles, two triples, 21 home runs and 84 walks. He has an on-base percentage of .363 while slugging .432.
• He ranks 73rd in batting average, 19th in on-base percentage, and 77th in slugging among all qualifying batters in MLB.
• Manny Machado is batting .272 with 33 doubles, 23 home runs and 51 walks, while slugging .452 with an on-base percentage of .333.
• Among qualifying hitters, he ranks 37th in batting average, 66th in on-base percentage and 55th in slugging percentage.
• Luis Arraez has an OPS of .707, fueled by an OBP of .320 and a team-best slugging percentage of .387 this season.
• Arraez has recorded a hit in two straight games. During his last five outings he is hitting .235 with two walks and an RBI.
• Ramon Laureano is batting .293 with a .356 OBP and 71 RBI for San Diego this season.

Rockies Player Leaders

• Hunter Goodman has a slugging percentage of .534 and has 135 hits, both team-best numbers for the Rockies. He's batting .280 and with an on-base percentage of .326.
• Including all qualified hitters in the big leagues, he is 24th in batting average, 84th in on-base percentage and 10th in slugging percentage.
• Mickey Moniak is hitting .262 with 17 doubles, eight triples, 19 home runs and 21 walks. He's slugging .494 with an on-base percentage of .301.
• Jordan Beck has racked up an on-base percentage of .329, a team-high for the Rockies.
• Brenton Doyle is batting .243 with 21 doubles, two triples, 14 home runs and 29 walks.

Padres vs Rockies Head to Head

• 9/11/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/7/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 9/6/2025: 10-8 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/5/2025: 3-0 COL (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/11/2025: 9-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/10/2025: 21-0 SD (Favorite: Padres, Spread: -1.5, Total: 12, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/9/2025: 13-9 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 4/13/2025: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/12/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 8-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)

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