Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 6:12 a.m.

The San Diego Padres will take on the Colorado Rockies in MLB action on Friday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Padres vs Rockies Game Info

• San Diego Padres (80-67) vs. Colorado Rockies (40-107)
• Date: Friday, September 12, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and COLR

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-310) | COL: (+250)
• Spread: SD: -1.5 (-144) | COL: +1.5 (+120)
• Total: 8 -- Over: (-106) | Under: (-114)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: JP Sears (Padres) - 0-0, 0.00 ERA vs Tanner Gordon (Rockies) - 5-6, 6.60 ERA

The Padres will look to JP Sears against the Rockies and Tanner Gordon (5-6). Sears did not pitch as the moneyline favorite in any games last season. The Rockies have a 7-4-0 ATS record in Gordon's 11 starts that had a set spread. The Rockies are 6-5 in Gordon's 11 starts this season that they were the moneyline underdog.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (68.4%)

Padres vs Rockies Moneyline

• The Padres vs Rockies moneyline has San Diego as a -310 favorite, while Colorado is a +250 underdog on the road.

Padres vs Rockies Spread

• The Rockies are +1.5 on the run line against the Padres. The Rockies are +120 to cover, and the Padres are -144.

Padres vs Rockies Over/Under

• A total of 8 runs has been set for the Padres-Rockies game on Sept. 12, with the over available at -106 and the under at -114.

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Padres vs Rockies Betting Trends

• The Padres have been favorites in 79 games this season and have come away with the win 47 times (59.5%) in those contests.
• San Diego has played as a favorite of -310 or more just one time this year and came away with a loss in that game.
• The Padres and their opponents have hit the over in 62 of their 145 games with a total set by oddsmakers this season.
• The Padres have an against the spread record of 78-67-0 in 145 games with a line this season.
• The Rockies have gone 36-103 in games they were the underdog on the moneyline (winning 25.9% of those games).
• Colorado has a 3-18 record (winning just 14.3% of its games) when it has played as a moneyline underdog of +250 or longer.
• In the 143 games bookmakers have set an over/under for the Rockies, they have combined with opponents to go over the total 61 times (61-77-5).
• The Rockies have collected a 57-86-0 record ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .260 with 27 doubles, two triples, 21 home runs and 84 walks. He has an on-base percentage of .363 while slugging .432.
• He ranks 74th in batting average, 19th in on-base percentage, and 77th in slugging among all qualifying hitters in the majors.
• Manny Machado is hitting .272 with 33 doubles, 23 home runs and 51 walks. He's slugging .452 with an on-base percentage of .333.
• Among qualifying hitters, he is 37th in batting average, 66th in on-base percentage and 55th in slugging percentage.
• Luis Arraez has an OPS of .707, fueled by an OBP of .320 and a team-best slugging percentage of .387 this season.
• Arraez takes a two-game hitting streak into this game. During his last five outings he is hitting .235 with two walks and an RBI.
• Ramon Laureano is batting .293 with a .356 OBP and 71 RBI for San Diego this season.

Rockies Player Leaders

• Hunter Goodman has racked up 135 hits with a .534 slugging percentage, both team-best marks for the Rockies. He's batting .280 and with an on-base percentage of .326.
• Including all qualifying hitters, he is 24th in batting average, while his on-base percentage is 84th and he is 11th in slugging.
• Mickey Moniak has 17 doubles, eight triples, 19 home runs and 21 walks while batting .262. He's slugging .494 with an on-base percentage of .301.
• Jordan Beck a has .329 on-base percentage to lead the Rockies.
• Brenton Doyle is hitting .243 with 21 doubles, two triples, 14 home runs and 29 walks.

Padres vs Rockies Head to Head

• 9/11/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/7/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 9/6/2025: 10-8 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/5/2025: 3-0 COL (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/11/2025: 9-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/10/2025: 21-0 SD (Favorite: Padres, Spread: -1.5, Total: 12, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/9/2025: 13-9 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 4/13/2025: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/12/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 8-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)

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