Tigers vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 5:12 p.m.

Saturday's slate in the MLB includes a matchup between the Detroit Tigers and the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Tigers vs White Sox Game Info

• Detroit Tigers (81-61) vs. Chicago White Sox (54-88)
• Date: Saturday, September 6, 2025
• Time: 6:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: FDSDET and CHSN

Tigers vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-300) | CHW: (+245)
• Spread: DET: -1.5 (-134) | CHW: +1.5 (+112)
• Total: 7 -- Over: (-122) | Under: (-100)

Tigers vs White Sox Probable Starting Pitchers

Probable Pitchers: Tarik Skubal (Tigers) - 12-4, 2.18 ERA vs Martín Pérez (White Sox) - 1-3, 2.16 ERA

The probable starters are Tarik Skubal (12-4) for the Tigers and Martin Perez (1-3) for the White Sox. Skubal and his team are 12-13-0 ATS this season when he starts. Skubal's team has a record of 17-6 this season when he starts and they are the favorite on the moneyline. The White Sox are 6-1-0 against the spread when Perez starts. The White Sox have been the moneyline underdog in seven of Pérez's starts this season, and they went 3-4 in those games.

Tigers vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (69.1%)

Tigers vs White Sox Moneyline

• Detroit is a -300 favorite on the moneyline, while Chicago is a +245 underdog on the road.

Tigers vs White Sox Spread

• The Tigers are hosting the White Sox and are favored by 1.5 runs (-134 to cover) on the runline. Chicago is +112 to cover.

Tigers vs White Sox Over/Under

• The over/under for Tigers-White Sox on Sept. 6 is 7. The over is -122, and the under is -100.

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Tigers vs White Sox Betting Trends

• The Tigers have been favorites in 92 games this season and have come away with the win 56 times (60.9%) in those contests.
• Detroit has played as a favorite of -300 or more just one time this year and came away with a win in that game.
• The Tigers' games have gone over the total in 68 of their 136 opportunities.
• In 136 games with a line this season, the Tigers have a mark of 65-71-0 against the spread.
• The White Sox have won 50 of the 134 games they were listed as the moneyline underdog this season (37.3%).
• Chicago has played in four games as a moneyline underdog with odds of +245 or longer without earning a win.
• In the 137 games bookmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 64 times (64-65-8).
• The White Sox have a 78-59-0 record ATS this season (covering 56.9% of the time).

Tigers Player Leaders

• Riley Greene leads Detroit with 142 hits and a team-best slugging percentage of .509. He's batting .269 with an on-base percentage of .323.
• Among all qualified hitters in MLB, he is 44th in batting average, 90th in on-base percentage, and 16th in slugging.
• Greene hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .263 with a double, two walks and two RBIs.
• Gleyber Torres leads Detroit with an OBP of .360 this season while batting .258 with 73 walks and 71 runs scored. He's slugging .390.
• Among all qualified, he is 81st in batting average, 23rd in on-base percentage and 120th in slugging percentage.
• Spencer Torkelson is batting .238 with a .466 slugging percentage and 72 RBI this year.
• Torkelson heads into this game with four games in a row with at least one hit. During his last five outings he is batting .278 with a double, two walks and two RBIs.
• Zach McKinstry has been key for Detroit with 110 hits, an OBP of .345 plus a slugging percentage of .449.
• McKinstry enters this matchup on a five-game hitting streak. During his last five outings he is hitting .412 with two doubles, a triple, two walks and three RBIs.

White Sox Player Leaders

• Andrew Benintendi has 15 doubles, two triples, 18 home runs and 35 walks while hitting .244. He's slugging .430 with an on-base percentage of .307.
• Lenyn Sosa has 119 hits while slugging .430. Both lead his team. He has a batting average of .263 with an on-base percentage of .294.
• He ranks 63rd in batting average, 138th in on-base percentage and 78th in slugging percentage in the majors.
• Chase Meidroth has 15 doubles, four home runs and 38 walks while batting .259.
• Mike Tauchman has 15 doubles, a triple, eight home runs and 40 walks while batting .271.

Tigers vs White Sox Head to Head

• 9/5/2025: 7-5 CHW (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/13/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/12/2025: 9-6 CHW (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 8/11/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2025: 3-2 CHW (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/3/2025: 8-1 CHW (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/2/2025: 13-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +194)
• 4/6/2025: 4-3 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/5/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 4/4/2025: 7-4 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)

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