Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 7:11 p.m.

MLB action on Saturday includes the San Diego Padres taking on the Colorado Rockies.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Padres vs Rockies Game Info

• San Diego Padres (76-65) vs. Colorado Rockies (40-101)
• Date: Saturday, September 6, 2025
• Time: 8:10 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: COLR and SDPA

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-245) | COL: (+205)
• Spread: SD: -1.5 (-142) | COL: +1.5 (+118)
• Total: 11 -- Over: (-115) | Under: (-105)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 3-6, 3.96 ERA vs McCade Brown (Rockies) - 0-2, 8.22 ERA

The Padres will give the ball to Randy Vasquez (3-6, 3.96 ERA), who is eyeing win No. 4 on the season, and the Rockies will counter with McCade Brown (0-2, 8.22 ERA). Vasquez and his team are 13-8-0 ATS this season when he starts. Vasquez's team is 5-1 this season when he starts and they are the moneyline favorite. Brown has started two games with set spreads, and the Rockies went 1-1-0. The Rockies were named the moneyline underdog for two Brown starts this season -- they lost both.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (66.8%)

Padres vs Rockies Moneyline

• Colorado is a +205 underdog on the moneyline, while San Diego is a -245 favorite on the road.

Padres vs Rockies Spread

• The Rockies are +1.5 on the spread (+118 to cover), and San Diego is -142 to cover the runline.

Padres vs Rockies Over/Under

• An over/under of 11 has been set for Padres-Rockies on Sept. 6, with the over being -115 and the under -105.

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Padres vs Rockies Betting Trends

• The Padres have come away with 43 wins in the 73 contests they have been listed as the favorites in this season.
• San Diego has been listed as a favorite of -245 or more on two occasions this season and split those games.
• The Padres and their opponents have hit the over in 61 of their 139 games with a total set by oddsmakers this season.
• The Padres have posted a record of 75-64-0 against the spread this season.
• The Rockies have won 27.1% of the games this season they were the moneyline underdog (36-97).
• Colorado has a 9-40 record (winning only 18.4% of its games) when playing as a moneyline underdog of +205 or longer.
• The Rockies have played in 137 games with an over/under set, and have combined with their opponents to go over the total 59 times (59-74-4).
• The Rockies have a 57-80-0 record ATS this season (covering 41.6% of the time).

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 19 home runs and 82 walks while batting .261. He has an on-base percentage of .367 and a slugging percentage of .429.
• Among qualified hitters in baseball, his batting average ranks 71st, his on-base percentage ranks 14th, and he is 79th in slugging.
• Tatis has hit safely in two games in a row. In his last five games he is batting .158 with a home run, three walks and an RBI.
• Manny Machado leads San Diego with 153 hits. He is batting .281 this season and has 54 extra-base hits. He's also slugging .461 with an on-base percentage of .342.
• Among qualified hitters, his batting average ranks him 23rd, his on-base percentage 50th, and his slugging percentage 50th.
• Luis Arraez has an OPS of .709, fueled by an OBP of .318 and a team-best slugging percentage of .391 this season.
• Ramon Laureano has 22 home runs, 70 RBI and a batting average of .300 this season.
• Laureano brings a six-game hitting streak into this game. In his last 10 games he is hitting .316 with two doubles, three home runs, two walks and nine RBIs.

Rockies Player Leaders

• Hunter Goodman has racked up a team-high OBP (.331) and slugging percentage (.538), and paces the Rockies in hits (132, while batting .285).
• Including all the qualified hitters in the majors, his batting average ranks 20th, his on-base percentage ranks 74th, and he is 10th in slugging.
• Goodman enters this game on a three-game hitting streak. In his last five games he is batting .526 with two doubles, two home runs, a walk and 10 RBIs.
• Mickey Moniak has 17 doubles, eight triples, 18 home runs and 20 walks while hitting .266. He's slugging .501 with an on-base percentage of .305.
• Jordan Beck has a team-best .331 on-base percentage.
• Brenton Doyle has 19 doubles, two triples, 14 home runs and 29 walks while batting .247.

Padres vs Rockies Head to Head

• 9/5/2025: 3-0 COL (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/11/2025: 9-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/10/2025: 21-0 SD (Favorite: Padres, Spread: -1.5, Total: 12, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/9/2025: 13-9 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 4/13/2025: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/12/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 8-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/18/2024: 3-2 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/17/2024: 8-3 SD (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 8/16/2024: 7-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

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