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Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

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Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 5:15 a.m.

The San Diego Padres are among the MLB squads in action on Saturday, versus the Colorado Rockies.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Padres vs Rockies Game Info

  • San Diego Padres (76-65) vs. Colorado Rockies (40-101)
  • Date: Saturday, September 6, 2025
  • Time: 8:10 p.m. ET
  • Venue: Coors Field -- Denver, Colorado
  • Coverage: COLR and SDPA

Padres vs Rockies Odds & Moneyline

  • All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
  • Moneyline: SD: (-190) | COL: (+160)
  • Spread: SD: -1.5 (-137) | COL: +1.5 (+114)
  • Total: 12 -- Over: (-104) | Under: (-118)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 0-0, 0.00 ERA vs McCade Brown (Rockies) - 0-2, 8.22 ERA

The Padres will give the nod to Randy Vasquez and the Rockies will counter with McCade Brown (0-2, 8.22 ERA). Vasquez did not pitch as the moneyline favorite in any games last season. Brown has started two games with set spreads, and the Rockies went 1-1-0. The Rockies were named the moneyline underdog for two Brown starts this season -- they lost both.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (66.8%)

Padres vs Rockies Moneyline

  • Colorado is the underdog, +160 on the moneyline, while San Diego is a -190 favorite despite being on the road.

Padres vs Rockies Spread

  • The Rockies are at +1.5 on the runline against the Padres. The Rockies are +114 to cover the spread, and the Padres are -137.

Padres vs Rockies Over/Under

  • Padres versus Rockies, on Sept. 6, has an over/under of 12, with the over being -104 and the under -118.

Bet on San Diego Padres vs. Colorado Rockies on FanDuel today!

Padres vs Rockies Betting Trends

  • The Padres have been favorites in 73 games this season and have come away with the win 43 times (58.9%) in those contests.
  • San Diego has a record of 9-5 in contests when oddsmakers favor them by -190 or more on the moneyline.
  • The Padres and their opponents have hit the over in 61 of their 139 games with a total set by oddsmakers this season.
  • The Padres have an against the spread mark of 75-64-0 in 139 games with a line this season.
  • The Rockies have been the moneyline underdog 133 total times this season. They've gone 36-97 in those games.
  • Colorado has a 22-74 record (winning just 22.9% of its games) when playing as a moneyline underdog of +160 or longer.
  • The Rockies have had an over/under set by bookmakers 137 times, and have combined with opponents to go over the total in 59 of those games (59-74-4).
  • The Rockies have collected a 57-80-0 record ATS this season (covering 41.6% of the time).

Padres Player Leaders

  • Fernando Tatis Jr. has 27 doubles, two triples, 19 home runs and 82 walks while hitting .261. He has an on-base percentage of .367 and a slugging percentage of .429.
  • Among the qualifying batters in baseball, his batting average ranks 71st, his on-base percentage ranks 14th, and he is 80th in slugging.
  • Tatis will look for his third straight game with a hit in this contest. In his last five games he is hitting .158 with a home run, three walks and an RBI.
  • Manny Machado has 153 hits, which ranks first among San Diego batters this season. He's batting .281 with 54 extra-base hits. He's also slugging .461 with an on-base percentage of .342.
  • Among qualifying hitters, he is 23rd in batting average, 50th in on-base percentage and 51st in slugging percentage.
  • Luis Arraez leads San Diego in slugging percentage (.391) powered by 40 extra-base hits.
  • Ramon Laureano is batting .300 with a .361 OBP and 70 RBI for San Diego this season.
  • Laureano brings a six-game hitting streak into this matchup. In his last 10 outings he is batting .316 with two doubles, three home runs, two walks and nine RBIs.

Rockies Player Leaders

  • Hunter Goodman has racked up 132 hits with a .331 on-base percentage and a .538 slugging percentage, all club-bests for the Rockies. He's batting .285.
  • Including all the qualifying players in MLB, his batting average ranks 20th, his on-base percentage ranks 73rd, and he is 10th in slugging.
  • Goodman hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .526 with two doubles, two home runs, a walk and 10 RBIs.
  • Mickey Moniak is hitting .266 with 17 doubles, eight triples, 18 home runs and 20 walks. He's slugging .501 with an on-base percentage of .305.
  • Jordan Beck a has .331 on-base percentage to pace the Rockies.
  • Brenton Doyle is batting .247 with 19 doubles, two triples, 14 home runs and 29 walks.

Padres vs Rockies Head to Head

  • 9/5/2025: 3-0 COL (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
  • 5/11/2025: 9-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
  • 5/10/2025: 21-0 SD (Favorite: Padres, Spread: -1.5, Total: 12, Favorite Moneyline: -240, Underdog Moneyline: +198)
  • 5/9/2025: 13-9 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
  • 4/13/2025: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
  • 4/12/2025: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +138)
  • 4/11/2025: 8-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
  • 8/18/2024: 3-2 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
  • 8/17/2024: 8-3 SD (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
  • 8/16/2024: 7-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

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