Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 7:11 p.m.

The MLB schedule on Saturday includes the St. Louis Cardinals taking on the San Francisco Giants.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Giants Game Info

• St. Louis Cardinals (70-72) vs. San Francisco Giants (72-69)
• Date: Saturday, September 6, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FOX

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | SF: (-102)
• Spread: STL: +1.5 (-192) | SF: -1.5 (+158)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 6-13, 5.37 ERA vs Justin Verlander (Giants) - 3-10, 4.29 ERA

The probable starters are Andre Pallante (6-13) for the Cardinals and Justin Verlander (3-10) for the Giants. Pallante's team is 13-14-0 against the spread in his starts this season. When Pallante starts a game and his team is the favorite on the moneyline, they have a record of 4-6. The Giants have a 7-17-0 ATS record in Verlander's 24 starts with a set spread. The Giants have been the moneyline underdog in 11 of Verlander's starts this season, and they went 3-8 in those games.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.8%)

Cardinals vs Giants Moneyline

• The moneyline numbers for Cardinals vs. Giants reveal St. Louis as the favorite (-116) and San Francisco as the underdog (-102) on the road.

Cardinals vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Cardinals. The Giants are +158 to cover, while the Cardinals are -192 to cover as a 1.5-run underdog on the runline.

Cardinals vs Giants Over/Under

• Cardinals versus Giants, on Sept. 6, has an over/under of 8.5, with the over being -104 and the under -118.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have been favorites in 62 games this season and have come away with the win 31 times (50%) in those contests.
• This year St. Louis has won 27 of 56 games when listed as at least -116 on the moneyline.
• Contests with the Cardinals have gone over the total set by bookmakers in 71 of 136 chances this season.
• The Cardinals are 69-67-0 against the spread in their 136 games that had a posted line this season.
• The Giants have been the underdog on the moneyline 55 total times this season. They've gone 26-29 in those games.
• San Francisco has a record of 21-25 when playing as a moneyline underdog with odds of -102 or longer (45.7%).
• The Giants have combined with opponents to hit the over on the total 67 times this season for a 67-66-7 record against the over/under.
• The Giants have put together a 65-75-0 record ATS this season (covering 46.4% of the time).

Cardinals Player Leaders

• Masyn Winn is batting .253 with 27 doubles, nine home runs and 33 walks. He has an on-base percentage of .309 while slugging .365.
• Among all qualified hitters in baseball, his batting average ranks 89th, his on-base percentage ranks 116th, and he is 140th in slugging.
• Lars Nootbaar is hitting .240 with 22 doubles, a triple, 13 home runs and 55 walks. He's slugging .383 with an on-base percentage of .329.
• He is 118th in batting average, 81st in on-base percentage and 127th in slugging in the major leagues.
• Ivan Herrera has 89 hits this season and has a slash line of .283/.366/.452.
• Victor Scott II has been key for St. Louis with 80 hits, an OBP of .314 plus a slugging percentage of .312.

Giants Player Leaders

• Rafael Devers has put up an on-base percentage of .381 and has 140 hits, both team-high numbers for the Giants. He's batting .264 and slugging .496.
• Including all the qualifying hitters in the majors, his batting average puts him 62nd, his on-base percentage ranks eighth, and he is 21st in slugging.
• Devers brings a five-game hitting streak into this matchup. In his last five games he is batting .391 with a double, four home runs, two walks and eight RBIs.
• Jung Hoo Lee has 30 doubles, 11 triples, seven home runs and 44 walks while batting .267. He's slugging .414 with an on-base percentage of .330.
• Including all qualified hitters, he ranks 52nd in batting average, 77th in on-base percentage and 91st in slugging percentage.
• Willy Adames is batting .230 with 18 doubles, two triples, 27 home runs and 66 walks.
• Heliot Ramos' .404 slugging percentage leads his team.

Cardinals vs Giants Head to Head

• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 6-3 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/23/2024: 5-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/22/2024: 9-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/20/2024: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/14/2023: 8-5 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/13/2023: 11-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/12/2023: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)

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