Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 5:15 a.m.

The St. Louis Cardinals are among the MLB squads playing on Saturday, up against the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Giants Game Info

• St. Louis Cardinals (70-72) vs. San Francisco Giants (72-69)
• Date: Saturday, September 6, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FOX

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | SF: (-102)
• Spread: STL: +1.5 (-192) | SF: -1.5 (+158)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 6-13, 5.37 ERA vs Justin Verlander (Giants) - 3-10, 4.29 ERA

The Cardinals will call on Andre Pallante (6-13) against the Giants and Justin Verlander (3-10). Pallante and his team are 13-14-0 ATS this season when he starts. Pallante's team has won 40% of his starts when they are favored on the moneyline (4-6). The Giants have a 7-17-0 ATS record in Verlander's 24 starts with a set spread. The Giants have been the underdog on the moneyline in 11 of Verlander's starts this season, and they went 3-8 in those games.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.9%)

Cardinals vs Giants Moneyline

• The Cardinals vs Giants moneyline has St. Louis as a -116 favorite, while San Francisco is a -102 underdog on the road.

Cardinals vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Cardinals. The Giants are +158 to cover, while the Cardinals are -192 to cover as a 1.5-run underdog on the runline.

Cardinals vs Giants Over/Under

• The Cardinals-Giants contest on Sept. 6 has been given an over/under of 8.5 runs. The over is set at -104 and the under at -118.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have been favorites in 62 games this season and have come away with the win 31 times (50%) in those contests.
• This season St. Louis has been victorious 27 times in 56 chances when named as a favorite of at least -116 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 71 of their 136 opportunities.
• In 136 games with a line this season, the Cardinals have a mark of 69-67-0 against the spread.
• The Giants have won 26 of the 55 games they were the underdog on the moneyline this season (47.3%).
• When playing as a moneyline underdog with odds of -102 or longer, San Francisco has gone 21-25 (45.7%).
• The Giants have played in 140 games with an over/under set, and have combined with opponents to go over the total 67 times (67-66-7).
• The Giants have put together a 65-75-0 record ATS this season (covering 46.4% of the time).

Cardinals Player Leaders

• Masyn Winn has 27 doubles, nine home runs and 33 walks while batting .253. He has an on-base percentage of .309 and a slugging percentage of .365.
• Among all qualified batters, he ranks 88th in batting average, his on-base percentage ranks 116th, and he is 140th in slugging.
• Lars Nootbaar is batting .240 with 22 doubles, a triple, 13 home runs and 55 walks. He's slugging .383 with an on-base percentage of .329.
• He ranks 118th in batting average, 80th in on-base percentage and 127th in slugging among qualified batters.
• Ivan Herrera has 89 hits this season and has a slash line of .283/.366/.452.
• Victor Scott II is batting .225 with a .314 OBP and 36 RBI for St. Louis this season.

Giants Player Leaders

• Rafael Devers has racked up 140 hits with a .381 on-base percentage, leading the Giants in both statistics. He's batting .264 and slugging .496.
• Including all qualified hitters in MLB, he is 62nd in batting average, eighth in on-base percentage and 20th in slugging percentage.
• Devers heads into this matchup on a five-game hitting streak. During his last five outings he is hitting .391 with a double, four home runs, two walks and eight RBIs.
• Jung Hoo Lee is batting .267 with 30 doubles, 11 triples, seven home runs and 44 walks. He's slugging .414 with an on-base percentage of .330.
• His batting average is 52nd among all qualified players, his on-base percentage is 76th, and he is 92nd in slugging.
• Willy Adames is batting .230 with 18 doubles, two triples, 27 home runs and 66 walks.
• Heliot Ramos is slugging .404 to pace his team.

Cardinals vs Giants Head to Head

• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 6-3 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/23/2024: 5-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/22/2024: 9-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/20/2024: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/14/2023: 8-5 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/13/2023: 11-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/12/2023: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)

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