Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 6:13 p.m.

The Tuesday slate in MLB includes a matchup between the Detroit Tigers and the Cleveland Guardians.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Guardians Game Info

• Detroit Tigers (85-71) vs. Cleveland Guardians (84-72)
• Date: Tuesday, September 23, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSDET

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-164) | CLE: (+138)
• Spread: DET: -1.5 (+115) | CLE: +1.5 (-138)
• Total: 6.5 -- Over: (-120) | Under: (-102)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Tarik Skubal (Tigers) - 13-5, 2.23 ERA vs Gavin Williams (Guardians) - 11-5, 3.06 ERA

The probable pitchers are Tarik Skubal (13-5) for the Tigers and Gavin Williams (11-5) for the Guardians. Skubal and his team are 13-15-0 ATS this season when he starts. When Skubal starts a game and his team is the favorite on the moneyline, they have a record of 18-8. The Guardians are 14-16-0 against the spread when Williams starts. The Guardians have been the underdog on the moneyline in 19 of Williams' starts this season, and they went 9-10 in those matchups.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (62.5%)

Tigers vs Guardians Moneyline

• Looking at the moneyline for Guardians-Tigers, Cleveland is the underdog at +138, and Detroit is -164 playing on the road.

Tigers vs Guardians Spread

• The Guardians are hosting the Tigers, and are +1.5 on the runline. The Guardians are +115 to cover the spread, and the Tigers are -138.

Tigers vs Guardians Over/Under

• A combined run total of 6.5 has been set for Tigers-Guardians on Sept. 23, with the over at -120 and the under at -102.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have been favorites in 103 games this season and have come away with the win 58 times (56.3%) in those contests.
• This season Detroit has been victorious 27 times in 43 chances when named as a favorite of at least -164 on the moneyline.
• Contests with the Tigers have gone over the total set by sportsbooks in 77 of 150 chances this season.
• The Tigers are 70-80-0 against the spread in their 150 games with a line set by sportsbooks this season.
• The Guardians have won 46.5% of the games this season they were the moneyline underdog (40-46).
• Cleveland is 8-15 (winning only 34.8% of its games) when it has played as a moneyline underdog of +138 or longer.
• The Guardians have played in 153 games with an over/under set, and have combined with opponents to go over the total 65 times (65-82-6).
• The Guardians have an 84-69-0 record against the spread this season (covering 54.9% of the time).

Tigers Player Leaders

• Gleyber Torres leads Detroit with an OBP of .366 this season while batting .261 with 85 walks and 79 runs scored. He has a slugging percentage of .398.
• Among qualified hitters in the majors, he ranks 60th in batting average, 15th in on-base percentage, and 104th in slugging.
• Torres hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .444 with a double, three walks and an RBI.
• Riley Greene leads Detroit in slugging percentage (.491) and total hits (151) this season. He's batting .259 with an on-base percentage of .313.
• His batting average ranks 68th among qualified players, his on-base percentage 103rd, and his slugging percentage 19th.
• Spencer Torkelson is batting .243 with a .467 slugging percentage and 78 RBI this year.
• Zach McKinstry has 12 home runs, 49 RBI and a batting average of .260 this season.
• McKinstry brings a two-game hitting streak into this game. During his last five outings he is hitting .231 with a double, a home run, a walk and an RBI.

Guardians Player Leaders

• Jose Ramirez has accumulated 161 hits with a .359 on-base percentage, leading the Guardians in both categories. He's batting .282 and slugging .504.
• Including all qualified hitters in the majors, his batting average puts him 21st, his on-base percentage ranks 21st, and he is 15th in slugging.
• Ramirez enters this matchup on a five-game hitting streak. In his last five games he is hitting .316 with a double, two home runs, two walks and three RBIs.
• Steven Kwan paces his team with a .380 slugging percentage. He has a batting average of .276 with an on-base percentage of .335.
• He is currently 30th in batting average, 60th in on-base percentage and 123rd in slugging percentage among all qualifying batters.
• Kyle Manzardo is hitting .236 with 17 doubles, two triples, 26 home runs and 48 walks.
• Angel Martinez is hitting .226 with 23 doubles, two triples, 11 home runs and 22 walks.

Tigers vs Guardians Head to Head

• 9/18/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/17/2025: 4-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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