Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 12:12 p.m.

The Detroit Tigers versus the Cleveland Guardians is on the MLB schedule for Thursday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Tigers vs Guardians Game Info

• Detroit Tigers (85-67) vs. Cleveland Guardians (80-71)
• Date: Thursday, September 18, 2025
• Time: 1:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: FDSDET and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-240) | CLE: (+198)
• Spread: DET: -1.5 (-110) | CLE: +1.5 (-111)
• Total: 7 -- Over: (-124) | Under: (+102)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Tarik Skubal (Tigers) - 13-5, 2.26 ERA vs Tanner Bibee (Guardians) - 10-11, 4.44 ERA

This contest's pitching matchup is set, as the Tigers will send Tarik Skubal (13-5) to the mound, while Tanner Bibee (10-11) will take the ball for the Guardians. Skubal and his team are 13-14-0 ATS this season when he starts. When Skubal starts a game and his team is the favorite on the moneyline, they have a record of 18-7. The Guardians are 17-11-0 against the spread when Bibee starts. The Guardians have a 5-8 record in Bibee's 13 starts this season when they were the underdog on the moneyline.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (67.4%)

Tigers vs Guardians Moneyline

• The moneyline numbers for Tigers vs. Guardians reveal Detroit as the favorite (-240) and Cleveland as the underdog (+198) on the road.

Tigers vs Guardians Spread

• The Tigers are hosting the Guardians and are favored by 1.5 runs (-110 to cover) on the runline. Cleveland is -111 to cover.

Tigers vs Guardians Over/Under

• An over/under of 7 has been set for Tigers-Guardians on Sept. 18, with the over being -124 and the under +102.

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Tigers vs Guardians Betting Trends

• The Tigers have been favorites in 99 games this season and have come away with the win 58 times (58.6%) in those contests.
• Detroit has a record of 8-1 when favored by -240 or more this year.
• The Tigers' games have gone over the total in 75 of their 146 opportunities.
• The Tigers have an against the spread mark of 69-77-0 in 146 games with a line this season.
• The Guardians have been the underdog on the moneyline 84 total times this season. They've finished 38-46 in those games.
• Cleveland has played three times as a moneyline underdog with odds of +198 or longer, and lost each game.
• The Guardians have played in 148 games with an over/under set, and have combined with opponents to go over the total 64 times (64-78-6).
• The Guardians have covered 54.1% of their games this season, going 80-68-0 against the spread.

Tigers Player Leaders

• Gleyber Torres has 125 hits this season and a team-best OBP of .358. He has a .252 batting average and a slugging percentage of .391.
• Among all qualified batters in the majors, he is 87th in batting average, 22nd in on-base percentage, and 112th in slugging.
• Riley Greene leads Detroit in slugging percentage (.502) and total hits (149) this season. He's batting .263 with an on-base percentage of .319.
• His batting average is 54th among qualified players, his on-base percentage 96th, and his slugging percentage 14th.
• Spencer Torkelson is batting .240 with a .457 slugging percentage and 74 RBI this year.
• Kerry Carpenter has been key for Detroit with 105 hits, an OBP of .300 plus a slugging percentage of .520.
• Carpenter enters this game on a two-game hitting streak. During his last five outings he is batting .400 with two home runs, a walk and three RBIs.

Guardians Player Leaders

• Jose Ramirez has accumulated a team-high OBP (.357), while leading the Guardians in hits (155). He's batting .281 and slugging.
• Including all the qualified hitters in the big leagues, he ranks 21st in batting average, 25th in on-base percentage and 17th in slugging percentage.
• Steven Kwan is slugging .377 to lead his team. He has a batting average of .275 with an on-base percentage of .335.
• He is currently 33rd in batting average, 60th in on-base percentage and 127th in slugging percentage among all qualifying batters.
• Kyle Manzardo has 17 doubles, two triples, 26 home runs and 47 walks while batting .241.
• Angel Martinez is hitting .230 with 22 doubles, two triples, 11 home runs and 19 walks.

Tigers vs Guardians Head to Head

• 9/17/2025: 4-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/12/2024: 7-3 CLE (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -116, Underdog Moneyline: -102)

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