Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 6:12 p.m.

The Detroit Tigers are among the MLB squads in action on Wednesday, up against the Cleveland Guardians.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Guardians Game Info

• Detroit Tigers (85-66) vs. Cleveland Guardians (79-71)
• Date: Wednesday, September 17, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: Fox Sports 1, FDSDET, and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-136) | CLE: (+116)
• Spread: DET: -1.5 (+146) | CLE: +1.5 (-176)
• Total: 8 -- Over: (-110) | Under: (-110)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 8-13, 4.69 ERA vs Gavin Williams (Guardians) - 10-5, 3.16 ERA

This contest's pitching matchup is set, as the Tigers will send Jack Flaherty (8-13) to the mound, while Gavin Williams (10-5) will get the nod for the Guardians. Flaherty and his team are 10-18-0 ATS this season when he starts. Flaherty's team has been victorious in 38.9% of the games he's started as the moneyline favorite with a record of 7-11. The Guardians are 13-16-0 against the spread when Williams starts. The Guardians have an 8-10 record in Williams' 18 starts this season when they were the moneyline underdog.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (68.4%)

Tigers vs Guardians Moneyline

• Looking at the moneyline for Tigers-Guardians, Detroit is the favorite at -136, and Cleveland is +116 playing on the road.

Tigers vs Guardians Spread

• The Guardians are at the Tigers, and are +1.5 on the runline. The Guardians are +146 to cover the spread, and the Tigers are -176.

Tigers vs Guardians Over/Under

• The Tigers-Guardians contest on Sept. 17 has been given an over/under of 8 runs. The over is set at -110 and the under at -110.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have won in 58, or 59.2%, of the 98 contests they have been named as odds-on favorites in this year.
• Detroit has a record of 43-23 when favored by -136 or more this year.
• The Tigers' games have gone over the total in 75 of their 145 opportunities.
• The Tigers are 69-76-0 against the spread in their 145 games with a line set by sportsbooks this season.
• The Guardians are 37-46 in games they were the underdog on the moneyline (winning 44.6% of those games).
• Cleveland has a 22-18 record (winning 55% of its games) when playing as a moneyline underdog of +116 or longer.
• In the 147 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 64 times (64-77-6).
• The Guardians have covered 53.7% of their games this season, going 79-68-0 ATS.

Tigers Player Leaders

• Gleyber Torres leads Detroit in OBP (.361) this season, fueled by 125 hits. He has a .254 batting average and a slugging percentage of .394.
• Among all qualified hitters in the majors, he is 84th in batting average, 17th in on-base percentage, and 112th in slugging.
• Riley Greene leads Detroit in slugging percentage (.504) and total hits (149) this season. He's batting .265 with an on-base percentage of .319.
• He is 48th in batting average, 96th in on-base percentage and 14th in slugging among qualifying hitters.
• Spencer Torkelson has 127 hits this season and has a slash line of .242/.336/.461.
• Torkelson takes a three-game hitting streak into this game. During his last five outings he is hitting .368 with a home run, three walks and two RBIs.
• Zach McKinstry has been key for Detroit with 111 hits, an OBP of .336 plus a slugging percentage of .439.

Guardians Player Leaders

• Jose Ramirez has accumulated 155 hits with a .355 on-base percentage, leading the Guardians in both categories. He's batting .282 and slugging .500.
• Including all qualified hitters in the big leagues, he ranks 20th in batting average, 29th in on-base percentage and 18th in slugging percentage.
• Steven Kwan is slugging .377 to lead his team. He has a batting average of .274 with an on-base percentage of .334.
• He is currently 34th in batting average, 64th in on-base percentage and 127th in slugging percentage among all qualified hitters.
• Kyle Manzardo has 16 doubles, two triples, 26 home runs and 46 walks while batting .241.
• Angel Martinez has 22 doubles, two triples, 11 home runs and 19 walks while batting .228.

Tigers vs Guardians Head to Head

• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/12/2024: 7-3 CLE (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/10/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

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