TCU vs SMU Prediction, Odds, Picks, Best Bets for Week 4 2025

Saturday's slate in college football includes a matchup between the TCU Horned Frogs and the SMU Mustangs.

We've got you covered, in terms of the vital information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

TCU vs SMU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TCU: (-245) | SMU: (+198)
• Spread: TCU: -6.5 (-120) | SMU: +6.5 (-102)
• Total: 64.5 -- Over: (-115) | Under: (-105)

TCU vs SMU Betting Trends

• TCU hasn won once against the spread this season.
• TCU has no wins ATS (0-1) as a 6.5-point favorite or greater this year.
• Two of two TCU games have gone over the point total this season.
• SMU has not won a game against the spread this season.
• One SMU game (out of two) has gone over the point total this year.

TCU vs SMU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Mustangs win (52.7%)

TCU vs SMU Point Spread

TCU is a 6.5-point favorite against SMU. TCU is -120 to cover the spread, and SMU is -102.

TCU vs SMU Over/Under

TCU versus SMU on Sept. 20 has an over/under of 64.5 points, with the over -115 and the under -105.

TCU vs SMU Moneyline

TCU is a -245 favorite on the moneyline, while SMU is a +198 underdog.

TCU vs. SMU Points Insights

TCU vs. SMU Game Info

• Game day: Saturday, September 20, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN2
• Location: Fort Worth, Texas
• Stadium: Amon G. Carter Stadium

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Check out even more in-depth TCU vs. SMU analysis on FanDuel Research.