TCU vs SMU Prediction, Odds, Picks, Best Bets for Week 4 2025

College football's Saturday slate includes the TCU Horned Frogs facing the SMU Mustangs.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NCAA football betting odds.

TCU vs SMU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TCU: (-235) | SMU: (+190)
• Spread: TCU: -6.5 (-110) | SMU: +6.5 (-110)
• Total: 63.5 -- Over: (-105) | Under: (-115)

TCU vs SMU Betting Trends

• TCU has one win against the spread this season.
• TCU is winless ATS (0-1) as a 6.5-point favorite or greater this year.
• Two of two TCU games have gone over the point total this year.
• SMU has no wins against the spread this season.
• SMU has had one game (of two) go over the total this season.

TCU vs SMU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Mustangs win (52.7%)

TCU vs SMU Point Spread

TCU is favored by 6.5 points versus SMU. TCU is -110 to cover the spread, while SMU is -110.

TCU vs SMU Over/Under

TCU versus SMU on Sept. 20 has an over/under of 63.5 points, with the over -105 and the under -115.

TCU vs SMU Moneyline

TCU is a -235 favorite on the moneyline, while SMU is a +190 underdog.

TCU vs. SMU Points Insights

TCU vs. SMU Game Info

• Game day: Saturday, September 20, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN2
• Location: Fort Worth, Texas
• Stadium: Amon G. Carter Stadium

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Check out even more in-depth TCU vs. SMU analysis on FanDuel Research.