South Carolina vs Kentucky Prediction, Odds, Picks, Best Bets for Week 5 2025

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The South Carolina Gamecocks will take on the Kentucky Wildcats in college football action on Saturday.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

South Carolina vs Kentucky Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: South Carolina: (-215) | Kentucky: (+176)
Spread: South Carolina: -5.5 (-114) | Kentucky: +5.5 (-106)
Total: 47.5 -- Over: (-110) | Under: (-110)

South Carolina has posted two wins against the spread this season.
South Carolina has won once ATS (1-1) as a 5.5-point or higher favorite this year.
One of South Carolina's four games this season has hit the over.
Kentucky has one win against the spread this year.
Kentucky has covered every time (1-0) as a 5.5-point or greater underdog this season.
Kentucky has played two games (out of three) which finished over the total this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Gamecocks win (72.3%)

Kentucky is the underdog by 5.5 points against South Carolina. Kentucky is -114 to cover the spread, and South Carolina is -106.

The South Carolina-Kentucky matchup on Sept. 27 has been given an over/under of 47.5 points. The over is -110 and the under is -110.

Kentucky is a +176 underdog on the moneyline, while South Carolina is a -215 favorite.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
South Carolina	22.3	96	20.3	57	50.3	4
Kentucky	31.7	88	23.0	46	49.5	3

Check out even more in-depth South Carolina vs. Kentucky analysis on FanDuel Research.

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