South Carolina vs Kentucky Prediction, Odds, Picks, Best Bets for Week 5 2025

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The South Carolina Gamecocks versus the Kentucky Wildcats is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NCAA football betting odds.

South Carolina vs Kentucky Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: South Carolina: (-210) | Kentucky: (+172)
Spread: South Carolina: -5.5 (-110) | Kentucky: +5.5 (-110)
Total: 46.5 -- Over: (-106) | Under: (-114)

South Carolina has posted two wins against the spread this year.
As a 5.5-point or greater favorite, South Carolina has one win ATS (1-1) this season.
One of four South Carolina games have gone over the point total this year.
Kentucky has one win against the spread this season.
Kentucky has yet to lose ATS (1-0) as a 5.5-point underdog or greater this season.
Kentucky has played two games (out of three) which finished over the total this year.

All college football win probability predictions and picks are according to numberFire.
Prediction: Gamecocks win (72.2%)

South Carolina is favored by 5.5 points versus Kentucky. South Carolina is -110 to cover the spread, while Kentucky is -110.

An over/under of 46.5 has been set for South Carolina-Kentucky on Sept. 27, with the over being -106 and the under -114.

Kentucky is a +172 underdog on the moneyline, while South Carolina is a -210 favorite.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
South Carolina	22.3	95	20.3	59	50.3	4
Kentucky	31.7	88	23.0	48	49.5	3

Check out even more in-depth South Carolina vs. Kentucky analysis on FanDuel Research.

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