Reds vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 6:11 p.m.

The Cincinnati Reds versus the Washington Nationals is on the MLB schedule for Monday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Reds vs Nationals Game Info

• Cincinnati Reds (52-48) vs. Washington Nationals (39-60)
• Date: Monday, July 21, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and FDSOH

Reds vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-122) | WSH: (+104)
• Spread: CIN: -1.5 (+122) | WSH: +1.5 (-146)
• Total: 9 -- Over: (-118) | Under: (-104)

Reds vs Nationals Probable Starting Pitchers

Probable Pitchers: Brady Singer (Reds) - 7-7, 4.32 ERA vs Jake Irvin (Nationals) - 7-5, 4.58 ERA

The Reds will give the nod to Brady Singer (7-7) against the Nationals and Jake Irvin (7-5). When Singer starts, his team is 10-7-0 against the spread this season. Singer's team has won 42.9% of his starts when they are favored on the moneyline (3-4). The Nationals are 11-8-0 ATS in Irvin's 19 starts that had a set spread. The Nationals have a 10-8 record in Irvin's 18 starts this season when they were the moneyline underdog.

Reds vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (59.4%)

Reds vs Nationals Moneyline

• The moneyline numbers for Reds vs. Nationals reveal Cincinnati as the favorite (-122) and Washington as the underdog (+104) despite being the home team.

Reds vs Nationals Spread

• The Nationals are +1.5 on the spread (-146 to cover), and Cincinnati is +122 to cover the runline.

Reds vs Nationals Over/Under

• Reds versus Nationals on July 21 has an over/under of 9 runs, with the odds on the over -118 and the under set at -104.

Bet on Cincinnati Reds vs. Washington Nationals on FanDuel today!

Reds vs Nationals Betting Trends

• The Reds have been chosen as favorites in 39 games this year and have walked away with the win 21 times (53.8%) in those games.
• Cincinnati has a record of 15-11 when favored by -122 or more this year.
• The Reds and their opponents have hit the over in 41 of their 94 games with a total set by oddsmakers this season.
• The Reds are 50-44-0 against the spread in their 94 games with a line set by sportsbooks this season.
• The Nationals have won 33 of the 75 games they were the moneyline underdog this season (44%).
• When playing as a moneyline underdog with odds of +104 or longer, Washington has a 28-36 record (winning 43.8% of its games).
• The Nationals have combined with opponents to go over the total 53 times this season for a 53-38-2 record against the over/under.
• The Nationals have put together a 47-46-0 record against the spread this season (covering 50.5% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 107 hits and a team-best slugging percentage of .486. He's batting .281 with an on-base percentage of .357.
• Among all qualified hitters, he is 33rd in batting average, his on-base percentage ranks 39th, and he is 31st in slugging.
• TJ Friedl leads Cincinnati in OBP (.364) this season, fueled by 97 hits. He's batting .267 while slugging .394.
• Among qualifying hitters, he is 63rd in batting average, 27th in on-base percentage and 110th in slugging percentage.
• Spencer Steer has 83 hits this season and has a slash line of .249/.308/.398.
• Matt McLain is batting .215 with a .304 OBP and 35 RBI for Cincinnati this season.
• McLain brings a six-game hitting streak into this game. During his last 10 games he is batting .282 with two doubles, two home runs, five walks and four RBIs.

Nationals Player Leaders

• James Wood has 100 hits with a .375 on-base percentage and a .520 slugging percentage, all club-bests for the Nationals. He's batting .272.
• Including all the qualified hitters in MLB, his batting average ranks 54th, his on-base percentage ranks 15th, and he is 15th in slugging.
• C.J. Abrams is batting .283 with 21 doubles, four triples, 13 home runs and 24 walks. He's slugging .484 with an on-base percentage of .347.
• Including all qualifying hitters, he ranks 28th in batting average, 51st in on-base percentage and 32nd in slugging percentage.
• Luis Garcia is batting .260 with 20 doubles, seven home runs and 19 walks.
• Nathaniel Lowe is hitting .229 with 14 doubles, two triples, 15 home runs and 34 walks.

Reds vs Nationals Head to Head

• 5/4/2025: 4-1 WSH (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/3/2025: 11-6 WSH (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 7/21/2024: 5-2 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2024: 5-4 WSH (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/19/2024: 8-5 WSH (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 3/31/2024: 6-5 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 3/30/2024: 7-6 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 3/28/2024: 8-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/6/2023: 6-3 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/5/2023: 7-3 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -235, Underdog Moneyline: +194)

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