Reds vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 6:11 a.m.

The Cincinnati Reds will take on the Washington Nationals in MLB action on Monday.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Nationals Game Info

• Cincinnati Reds (52-48) vs. Washington Nationals (39-60)
• Date: Monday, July 21, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and FDSOH

Reds vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-134) | WSH: (+114)
• Spread: CIN: -1.5 (+128) | WSH: +1.5 (-154)
• Total: 9 -- Over: (-100) | Under: (-122)

Reds vs Nationals Probable Starting Pitchers

Probable Pitchers: Brady Singer (Reds) - 7-7, 4.32 ERA vs Jake Irvin (Nationals) - 7-5, 4.58 ERA

This contest's pitching matchup is set, as the Reds will send Brady Singer (7-7) to the mound, while Jake Irvin (7-5) will get the nod for the Nationals. When Singer starts, his team is 10-7-0 against the spread this season. Singer's team has been victorious in 42.9% of the games he's started as the moneyline favorite with a record of 3-4. When Irvin starts, the Nationals are 11-8-0 against the spread. The Nationals have been the underdog on the moneyline in 18 of Irvin's starts this season, and they went 10-8 in those matchups.

Reds vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (59.4%)

Reds vs Nationals Moneyline

• Looking at the moneyline for Reds-Nationals, Cincinnati is the favorite at -134, and Washington is +114 playing at home.

Reds vs Nationals Spread

• The Nationals are at +1.5 on the runline against the Reds. The Nationals are -154 to cover the spread, and the Reds are +128.

Reds vs Nationals Over/Under

• A combined run total of 9 has been set for Reds-Nationals on July 21, with the over at -100 and the under at -122.

Bet on Cincinnati Reds vs. Washington Nationals on FanDuel today!

Reds vs Nationals Betting Trends

• The Reds have been favorites in 39 games this season and have come away with the win 21 times (53.8%) in those contests.
• This season Cincinnati has come away with a win 11 times in 18 chances when named as a favorite of at least -134 on the moneyline.
• The Reds' games have gone over the total in 41 of their 94 opportunities.
• The Reds are 50-44-0 against the spread in their 94 games that had a posted line this season.
• The Nationals have compiled a 33-42 record in games they were the underdog on the moneyline (winning 44% of those games).
• When playing as a moneyline underdog with odds of +114 or longer, Washington has a 25-35 record (winning 41.7% of its games).
• The Nationals have played in 93 games with a set over/under, and have combined with opponents to go over the total 53 times (53-38-2).
• The Nationals have a 47-46-0 record ATS this season (covering 50.5% of the time).

Reds Player Leaders

• Elly De La Cruz has 107 hits to go with a slugging percentage of .486, both of which rank first among Cincinnati hitters this season. He has a .281 batting average and an on-base percentage of .357.
• Among qualified hitters in baseball, he is 33rd in batting average, 39th in on-base percentage, and 31st in slugging.
• TJ Friedl leads Cincinnati with an OBP of .364 this season while batting .267 with 46 walks and 58 runs scored. He's slugging .394.
• His batting average is 63rd among qualified players, his on-base percentage 27th, and his slugging percentage 110th.
• Spencer Steer is batting .249 with a .398 slugging percentage and 40 RBI this year.
• Matt McLain has 11 home runs, 35 RBI and a batting average of .215 this season.
• McLain brings a six-game hitting streak into this matchup. During his last 10 games he is batting .282 with two doubles, two home runs, five walks and four RBIs.

Nationals Player Leaders

• James Wood has an on-base percentage of .375, a slugging percentage of .520, and has 100 hits, all club-highs for the Nationals (while batting .272).
• Including all the qualifying players in MLB, he ranks 54th in batting average, 15th in on-base percentage and 15th in slugging percentage.
• C.J. Abrams is hitting .283 with 21 doubles, four triples, 13 home runs and 24 walks. He's slugging .484 with an on-base percentage of .347.
• He is currently 28th in batting average, 51st in on-base percentage and 32nd in slugging percentage among all qualifying hitters.
• Luis Garcia is batting .260 with 20 doubles, seven home runs and 19 walks.
• Nathaniel Lowe has 14 doubles, two triples, 15 home runs and 34 walks while hitting .229.

Reds vs Nationals Head to Head

• 5/4/2025: 4-1 WSH (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/3/2025: 11-6 WSH (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 7/21/2024: 5-2 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2024: 5-4 WSH (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/19/2024: 8-5 WSH (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 3/31/2024: 6-5 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 3/30/2024: 7-6 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 3/28/2024: 8-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/6/2023: 6-3 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/5/2023: 7-3 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -235, Underdog Moneyline: +194)

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