Oklahoma vs South Carolina Prediction, Odds, Picks, Best Bets for Week 8 2025

Saturday's slate in college football includes a matchup between the Oklahoma Sooners and the South Carolina Gamecocks.

We've got you covered, in terms of the vital info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Oklahoma vs South Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oklahoma: (-196) | South Carolina: (+164)
• Spread: Oklahoma: -5.5 (-102) | South Carolina: +5.5 (-120)
• Total: 42.5 -- Over: (-110) | Under: (-110)

Oklahoma vs South Carolina Betting Trends

• Oklahoma is 3-3-0 against the spread this year.
• As at least a 5.5-point favorite, Oklahoma has two wins ATS (2-2).
• None of Oklahoma's six games has gone over the point total in 2025.
• South Carolina's record against the spread in 2025 is 3-3-0.
• South Carolina has one win ATS (1-1) as a 5.5-point underdog or more this season.
• A pair of South Carolina six games in 2025 have hit the over.

Oklahoma vs South Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Sooners win (50.2%)

Oklahoma vs South Carolina Point Spread

Oklahoma is favored by 5.5 points (-102 to cover) in this matchup. South Carolina, the underdog, is -120.

Oklahoma vs South Carolina Over/Under

A combined point total of 42.5 has been set for Oklahoma-South Carolina on Oct. 18, with the over at -110 and the under at -110.

Oklahoma vs South Carolina Moneyline

South Carolina is the underdog, +164 on the moneyline, while Oklahoma is a -196 favorite.

Oklahoma vs. South Carolina Points Insights

Oklahoma vs. South Carolina Game Info

• Game day: Saturday, October 18, 2025
• Game time: 12:45 p.m. ET
• TV channel: SEC Network
• Location: Columbia, South Carolina
• Stadium: Williams-Brice Stadium

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Check out even more in-depth Oklahoma vs. South Carolina analysis on FanDuel Research.