Reds vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 1:12 p.m.

The Sunday slate in MLB includes a matchup between the Cincinnati Reds and the Chicago Cubs.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Reds vs Cubs Game Info

• Cincinnati Reds (79-76) vs. Chicago Cubs (88-67)
• Date: Sunday, September 21, 2025
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and MARQ+

Reds vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-124) | CHC: (+106)
• Spread: CIN: -1.5 (+150) | CHC: +1.5 (-182)
• Total: 9 -- Over: (-100) | Under: (-122)

Reds vs Cubs Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 9-7, 2.88 ERA vs Jameson Taillon (Cubs) - 10-6, 3.93 ERA

This contest's pitching matchup is set, as the Reds will send Andrew Abbott (9-7) to the mound, while Jameson Taillon (10-6) will take the ball for the Cubs. Abbott's team is 14-12-0 against the spread in his starts this season. Abbott's team has been victorious in 56.2% of the games he's started as the moneyline favorite with a record of 9-7. The Cubs have gone 10-10-0 ATS in Taillon's 20 starts with a set spread. The Cubs have been the moneyline underdog in seven of Taillon's starts this season, and they went 3-4 in those matchups.

Reds vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (50.6%)

Reds vs Cubs Moneyline

• Chicago is a +106 underdog on the moneyline, while Cincinnati is a -124 favorite at home.

Reds vs Cubs Spread

• The Cubs are at the Reds, and are +1.5 on the runline. The Cubs are +150 to cover the spread, and the Reds are -182.

Reds vs Cubs Over/Under

• The over/under for the Reds versus Cubs game on Sept. 21 has been set at 9, with -100 odds on the over and -122 odds on the under.

Bet on Cincinnati Reds vs. Chicago Cubs on FanDuel today!

Reds vs Cubs Betting Trends

• The Reds have been chosen as favorites in 63 games this year and have walked away with the win 34 times (54%) in those games.
• Cincinnati has a record of 20-17 when favored by -124 or more this year.
• The Reds' games have gone over the total in 58 of their 148 opportunities.
• The Reds have an against the spread mark of 77-71-0 in 148 games with a line this season.
• The Cubs have gone 18-25 in games they were the underdog on the moneyline (winning 41.9% of those games).
• In games it has played as a moneyline underdog with odds of +106 or longer, Chicago has a 10-15 record (winning 40% of its games).
• In the 151 games oddsmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 69 times (69-71-11).
• The Cubs have covered 47% of their games this season, going 71-80-0 against the spread.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.437) and total hits (158) this season. He's batting .262 with an on-base percentage of .336.
• Among all qualified batters in the majors, he is 59th in batting average, 56th in on-base percentage, and 68th in slugging.
• De La Cruz will look for his third straight game with a hit in this matchup. During his last five outings he is hitting .231 with a double, a home run, five walks and an RBI.
• TJ Friedl has 143 hits this season and a team-best OBP of .362. He's batting .259 and slugging .373.
• His batting average is 67th among qualified players, his on-base percentage 18th, and his slugging percentage 127th.
• Friedl takes a two-game streak with at least one hit into this contest. In his last five games he is batting .211 with a home run, two walks and three RBIs.
• Spencer Steer has collected 118 base hits, an OBP of .312 and a slugging percentage of .422 this season.
• Steer brings a two-game hitting streak into this game. During his last five outings he is hitting .389 with four home runs, a walk and 10 RBIs.
• Austin Hays has been key for Cincinnati with 101 hits, an OBP of .316 plus a slugging percentage of .454.

Cubs Player Leaders

• Nico Hoerner has a team-high .398 slugging percentage. He's batting .301 with an on-base percentage of .350.
• Including all the qualified hitters in the majors, his batting average ranks eighth, his on-base percentage is 35th, and he is 105th in slugging.
• Pete Crow-Armstrong has 37 doubles, four triples, 29 home runs and 29 walks while hitting .246. He's slugging .478 with an on-base percentage of .287.
• His batting average is 96th among all qualified players, his on-base percentage is 137th, and he is 31st in slugging.
• Ian Happ has 29 doubles, 23 home runs and 85 walks while batting .241.
• Seiya Suzuki is batting .242 with 30 doubles, three triples, 27 home runs and 69 walks.

Reds vs Cubs Head to Head

• 9/20/2025: 6-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/19/2025: 7-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/18/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/6/2025: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 5-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2025: 3-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/31/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/30/2025: 6-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/25/2025: 11-8 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)

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