Mets vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 1:12 p.m.

The New York Mets versus the Washington Nationals is on the MLB schedule for Sunday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Mets vs Nationals Game Info

• New York Mets (80-75) vs. Washington Nationals (63-92)
• Date: Sunday, September 21, 2025
• Time: 1:40 p.m. ET
• Venue: Citi Field -- Queens, New York
• Coverage: WPIX and MASN2

Mets vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYM: (-290) | WSH: (+235)
• Spread: NYM: -1.5 (-130) | WSH: +1.5 (+108)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Mets vs Nationals Probable Starting Pitchers

Probable Pitchers: Sean Manaea (Mets) - 2-3, 5.40 ERA vs Jake Irvin (Nationals) - 8-13, 5.76 ERA

The Mets will give the ball to Sean Manaea (2-3, 5.40 ERA), who is eyeing win No. 3 on the season, and the Nationals will turn to Jake Irvin (8-13, 5.76 ERA). Manaea and his team are 3-7-0 ATS this season when he starts. Manaea's team is 2-5 this season when he starts and they are the moneyline favorite. The Nationals have gone 15-15-0 against the spread when Irvin starts. The Nationals have been the underdog on the moneyline in 29 of Irvin's starts this season, and they went 13-16 in those matchups.

Mets vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mets win (74%)

Mets vs Nationals Moneyline

• The moneyline numbers for Mets vs. Nationals reveal New York as the favorite (-290) and Washington as the underdog (+235) on the road.

Mets vs Nationals Spread

• The Mets are 1.5-run home favorites on the runline against the Nationals. The Mets are -130 to cover, and the Nationals are +108.

Mets vs Nationals Over/Under

• Mets versus Nationals on Sept. 21 has an over/under of 8.5 runs, with the odds on the over -118 and the under set at -104.

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Mets vs Nationals Betting Trends

• The Mets have won in 61, or 57.5%, of the 106 contests they have been named as odds-on favorites in this year.
• This season New York has come away with a win six times in seven chances when named as a favorite of at least -290 on the moneyline.
• The Mets and their opponents have hit the over in 69 of their 148 games with a total set by oddsmakers this season.
• The Mets have posted a record of 69-79-0 against the spread this season.
• The Nationals have won 42.5% of the games this season they were the moneyline underdog (54-73).
• Washington has yet to play a game with moneyline odds of +235 or longer.
• The Nationals have played in 149 games with a set over/under, and have combined with their opponents to go over the total 80 times (80-62-7).
• The Nationals have covered 49% of their games this season, going 73-76-0 ATS.

Mets Player Leaders

• Juan Soto leads New York in OBP (.397) and total hits (147) this season. He's batting .266 batting average while slugging .533.
• Among qualifying batters in baseball, he ranks 45th in batting average, second in on-base percentage, and ninth in slugging.
• Soto has recorded at least one hit in five games in a row. During his last five outings he is hitting .381 with a double, two home runs, two walks and six RBIs.
• Francisco Lindor leads New York in slugging percentage (.454) thanks to 61 extra-base hits. He's batting .267 with an on-base percentage of .344.
• Among qualifiers, he ranks 43rd in batting average, 46th in on-base percentage and 55th in slugging percentage.
• Lindor has picked up a hit in nine straight games. In his last 10 games he is hitting .316 with two doubles, a home run, six walks and two RBIs.
• Pete Alonso has collected 162 base hits, an OBP of .349 and a slugging percentage of .526 this season.
• Alonso heads into this game with seven games in a row with at least one hit. During his last 10 outings he is batting .324 with a double, four home runs, four walks and nine RBIs.
• Brandon Nimmo has been key for New York with 145 hits, an OBP of .324 plus a slugging percentage of .437.

Nationals Player Leaders

• C.J. Abrams has racked up a slugging percentage of .438, a team-best for the Nationals. He's batting .261 with an on-base percentage of .321.
• Including all the qualified hitters in the big leagues, his batting average is 61st, his on-base percentage is 88th, and he is 65th in slugging.
• James Wood paces his team with 145 hits and a .349 on-base percentage, with a team-best .458 slugging percentage. He has a batting average of .253.
• He is currently 85th in batting average, 37th in on-base percentage and 49th in slugging percentage among all qualified hitters.
• Luis Garcia has 28 doubles, a triple, 13 home runs and 26 walks while batting .255.
• Josh Bell is batting .232 with 14 doubles, a triple, 20 home runs and 55 walks.

Mets vs Nationals Head to Head

• 9/20/2025: 5-3 WSH (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/19/2025: 12-6 NYM (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 8/21/2025: 9-3 WSH (Favorite: Mets, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/20/2025: 5-4 WSH (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/19/2025: 8-1 NYM (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 6/12/2025: 4-3 NYM (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 6/11/2025: 5-0 NYM (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/10/2025: 5-4 NYM (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/28/2025: 19-5 NYM (Favorite: Mets, Spread: -1.5, Total: 9.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 4/27/2025: 8-7 WSH (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)

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