Mets vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 11:11 p.m.

The New York Mets will take on the Washington Nationals in MLB action on Sunday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Mets vs Nationals Game Info

• New York Mets (80-75) vs. Washington Nationals (63-92)
• Date: Sunday, September 21, 2025
• Time: 1:40 p.m. ET
• Venue: Citi Field -- Queens, New York
• Coverage: WPIX and MASN2

Mets vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYM: (-270) | WSH: (+220)
• Spread: NYM: -1.5 (-125) | WSH: +1.5 (+104)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Mets vs Nationals Probable Starting Pitchers

Probable Pitchers: Sean Manaea (Mets) - 2-3, 5.40 ERA vs Jake Irvin (Nationals) - 8-13, 5.76 ERA

The Mets will look to Sean Manaea (2-3) against the Nationals and Jake Irvin (8-13). Manaea and his team are 3-7-0 ATS this season when he starts. Manaea's team has won 28.6% of his starts when they are favored on the moneyline (2-5). When Irvin starts, the Nationals have gone 15-15-0 against the spread. The Nationals are 13-16 in Irvin's 29 starts this season that they were the moneyline underdog.

Mets vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mets win (68.2%)

Mets vs Nationals Moneyline

• The moneyline numbers for Mets vs. Nationals reveal New York as the favorite (-270) and Washington as the underdog (+220) on the road.

Mets vs Nationals Spread

• The Mets are favored by 1.5 runs at home against the Nationals. The Mets are -125 to cover the spread, while the Nationals are +104.

Mets vs Nationals Over/Under

• The over/under for the Mets versus Nationals contest on Sept. 21 has been set at 8.5, with -114 odds on the over and -106 odds on the under.

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Mets vs Nationals Betting Trends

• The Mets have been favorites in 106 games this season and have come away with the win 61 times (57.5%) in those contests.
• This season New York has been victorious 11 times in 13 chances when named as a favorite of at least -270 on the moneyline.
• The Mets and their opponents have gone over the total this season in 69 of their 148 opportunities.
• The Mets have an against the spread record of 69-79-0 in 148 games with a line this season.
• The Nationals have been the moneyline underdog 127 total times this season. They've finished 54-73 in those games.
• When it has played as a moneyline underdog with odds of +220 or longer, Washington has gone 1-4 (20%).
• The Nationals have combined with opponents to hit the over on the total 80 times this season for an 80-62-7 record against the over/under.
• The Nationals have a 73-76-0 record against the spread this season (covering 49% of the time).

Mets Player Leaders

• Juan Soto leads New York with 147 hits and an OBP of .397 this season. He has a .266 batting average and a slugging percentage of .533.
• Among qualifying hitters in MLB, he is 46th in batting average, second in on-base percentage, and ninth in slugging.
• Soto has recorded a base hit in five straight games. During his last five outings he is hitting .381 with a double, two home runs, two walks and six RBIs.
• Francisco Lindor leads New York in slugging percentage (.454) thanks to 61 extra-base hits. He's batting .267 with an on-base percentage of .344.
• His batting average is 44th among qualified players, his on-base percentage 47th, and his slugging percentage 55th.
• Lindor takes a nine-game streak with at least one hit into this contest. In his last 10 outings he is hitting .316 with two doubles, a home run, six walks and two RBIs.
• Pete Alonso is batting .272 with a .526 slugging percentage and 122 RBI this year.
• Alonso has picked up a hit in seven straight games. In his last 10 outings he is hitting .324 with a double, four home runs, four walks and nine RBIs.
• Brandon Nimmo has been key for New York with 145 hits, an OBP of .324 plus a slugging percentage of .437.

Nationals Player Leaders

• C.J. Abrams has a .438 slugging percentage, which paces the Nationals. He's batting .261 with an on-base percentage of .321.
• He is 59th in batting average, 88th in on-base percentage and 66th in slugging percentage among all qualified hitters in MLB.
• James Wood paces his team with 145 hits and a .349 OBP, with a team-leading .458 slugging percentage. He has a batting average of .253.
• His batting average is 85th among all qualified players, his on-base percentage is 38th, and he is 49th in slugging.
• Luis Garcia is hitting .255 with 28 doubles, a triple, 13 home runs and 26 walks.
• Josh Bell is batting .232 with 14 doubles, a triple, 20 home runs and 55 walks.

Mets vs Nationals Head to Head

• 9/20/2025: 5-3 WSH (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/19/2025: 12-6 NYM (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 8/21/2025: 9-3 WSH (Favorite: Mets, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/20/2025: 5-4 WSH (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/19/2025: 8-1 NYM (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 6/12/2025: 4-3 NYM (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 6/11/2025: 5-0 NYM (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/10/2025: 5-4 NYM (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/28/2025: 19-5 NYM (Favorite: Mets, Spread: -1.5, Total: 9.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 4/27/2025: 8-7 WSH (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)

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