Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 2:12 p.m.

The MLB slate on Sunday includes the Cleveland Guardians taking on the Minnesota Twins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Guardians vs Twins Game Info

• Cleveland Guardians (84-71) vs. Minnesota Twins (66-89)
• Date: Sunday, September 21, 2025
• Time: 2:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and CLEG

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-144) | MIN: (+122)
• Spread: CLE: -1.5 (+112) | MIN: +1.5 (-134)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 5-3, 3.27 ERA vs Simeon Woods Richardson (Twins) - 7-4, 4.31 ERA

This contest's pitching matchup is set, as the Guardians will send Joey Cantillo (5-3) to the mound, while Simeon Woods Richardson (7-4) will get the nod for the Twins. Cantillo's team is 7-4-0 against the spread this season in his starts. Cantillo's team has won 66.7% of his starts when they are favored on the moneyline (4-2). The Twins have an 11-8-0 record against the spread in Woods Richardson's starts. The Twins are 5-3 in Woods Richardson's eight starts this season that they were the moneyline underdog.

Guardians vs Twins Moneyline

• Cleveland is a -144 favorite on the moneyline, while Minnesota is a +122 underdog at home.

Guardians vs Twins Spread

• The Twins are +1.5 on the run line against the Guardians. The Twins are -134 to cover, and the Guardians are +112.

Guardians vs Twins Over/Under

• Guardians versus Twins on Sept. 21 has an over/under of 8.5 runs, with the odds on the over -118 and the under set at -104.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have won in 42, or 65.6%, of the 64 contests they have been named as odds-on favorites in this year.
• This season Cleveland has been victorious 11 times in 14 chances when named as a favorite of at least -144 on the moneyline.
• The Guardians and their opponents have gone over in 65 of their 152 games with a total set by sportsbooks this season.
• The Guardians are 84-68-0 against the spread in their 152 games with a line set by sportsbooks this season.
• The Twins have won 22 of the 60 games they were listed as the moneyline underdog this season (36.7%).
• Minnesota is 7-14 (winning only 33.3% of its games) when playing as a moneyline underdog of +122 or longer.
• The Twins have combined with opponents to go over the total 72 times this season for a 72-71-7 record against the over/under.
• The Twins have a 71-79-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez has 160 hits and an OBP of .359, both of which lead Cleveland hitters this season. He has a .282 batting average and a slugging percentage of .506.
• Among all qualified hitters in the majors, he ranks 21st in batting average, 22nd in on-base percentage, and 14th in slugging.
• Ramirez has hit safely in four straight games. During his last five outings he is batting .294 with a double, two home runs, five walks and three RBIs.
• Steven Kwan has hit 10 homers this season while driving in 54 runs. He's batting .276 this season and slugging .376 with an on-base percentage of .335.
• Among all qualified, he is 31st in batting average, 59th in on-base percentage and 125th in slugging percentage.
• Kwan has picked up at least one hit in three games in a row. During his last five outings he is hitting .318 with a double, two walks and five RBIs.
• Kyle Manzardo has collected 105 base hits, an OBP of .318 and a slugging percentage of .457 this season.
• Angel Martinez is batting .228 with a .271 OBP and 45 RBI for Cleveland this season.

Twins Player Leaders

• Byron Buxton has racked up an on-base percentage of .329, a slugging percentage of .540, and has 123 hits, all club-bests for the Twins (while batting .266).
• Including all the qualified hitters in the majors, he ranks 45th in batting average, 75th in on-base percentage and sixth in slugging percentage.
• Trevor Larnach is hitting .251 with 22 doubles, a triple, 17 home runs and 53 walks. He's slugging .405 with an on-base percentage of .325.
• His batting average is 89th among all qualified players, his on-base percentage is 81st, and he is 93rd in slugging.
• Brooks Lee has 15 doubles, a triple, 15 home runs and 30 walks while hitting .239.
• Royce Lewis is hitting .239 with 17 doubles, 12 home runs and 25 walks.

Guardians vs Twins Head to Head

• 9/20/2025: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/20/2025: 6-0 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/3/2025: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/2/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/1/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/21/2025: 5-1 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/1/2025: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/30/2025: 4-2 CLE (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2025: 11-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!