Red Sox vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 6:13 p.m.

The MLB's Wednesday schedule includes the Boston Red Sox taking on the Athletics.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs Athletics Game Info

• Boston Red Sox (82-69) vs. Athletics (71-80)
• Date: Wednesday, September 17, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and NBCS-CA

Red Sox vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-166) | OAK: (+140)
• Spread: BOS: -1.5 (+116) | OAK: +1.5 (-142)
• Total: 9 -- Over: (-110) | Under: (-110)

Red Sox vs Athletics Probable Starting Pitchers

Probable Pitchers: Lucas Giolito (Red Sox) - 10-4, 3.31 ERA vs Mason Barnett (Athletics) - 1-1, 8.53 ERA

The Red Sox will look to Lucas Giolito (10-4) against the Athletics and Mason Barnett (1-1). Giolito and his team have a record of 16-8-0 against the spread when he starts. When Giolito starts a game and his team is the favorite on the moneyline, they have a record of 9-3. When Barnett starts, the Athletics have gone 2-1-0 against the spread. The Athletics have been the underdog on the moneyline in three of Barnett's starts this season, and they went 2-1 in those games.

Red Sox vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (53.5%)

Red Sox vs Athletics Moneyline

• The Red Sox vs Athletics moneyline has the Red Sox as a -166 favorite, while the Athletics are a +140 underdog on the road.

Red Sox vs Athletics Spread

• The Red Sox are 1.5-run favorites on the runline against the Athletics. The Red Sox are +116 to cover, while the Athletics are -142 to cover.

Red Sox vs Athletics Over/Under

• Red Sox versus Athletics, on Sept. 17, has an over/under of 9, with the over being -110 and the under -110.

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Red Sox vs Athletics Betting Trends

• The Red Sox have been victorious in 54, or 57.4%, of the 94 contests they have been chosen as favorites in this season.
• This season, the Red Sox have come away with a win 16 times in 23 chances when named as a favorite of at least -166 or shorter on the moneyline.
• The Red Sox and their opponents have hit the over in 70 of their 150 games with a total this season.
• The Red Sox are 80-70-0 against the spread in their 150 games with a line set by sportsbooks this season.
• The Athletics have a 52-60 record in games they were listed as the moneyline underdog (winning 46.4% of those games).
• The Athletics have a record of 11-24 when they have played as a moneyline underdog with odds of +140 or longer (31.4%).
• The Athletics have played in 150 games with a set over/under, and have combined with their opponents to go over the total 74 times (74-70-6).
• The Athletics have put together an 80-70-0 record ATS this season (covering 53.3% of the time).

Red Sox Player Leaders

• Jarren Duran has 149 hits and an OBP of .334, both of which are best among Boston hitters this season. He has a .258 batting average and a slugging percentage of .449.
• Among all qualified hitters in MLB, he ranks 73rd in batting average, 64th in on-base percentage, and 59th in slugging.
• Duran will look for his fourth straight game with a hit in this contest. During his last five outings he is hitting .235 with a double, a triple, a home run, a walk and two RBIs.
• Trevor Story leads Boston in slugging percentage (.439) thanks to 51 extra-base hits. He's batting .265 with an on-base percentage of .310.
• Among all qualifying hitters, he is 48th in batting average, 110th in on-base percentage and 68th in slugging percentage.
• Story has picked up at least one hit in two games in a row. In his last five games he is hitting .300 with a double and an RBI.
• Alex Bregman is batting .275 with a .470 slugging percentage and 59 RBI this year.
• Ceddanne Rafaela has 16 home runs, 60 RBI and a batting average of .239 this season.

Athletics Player Leaders

• Brent Rooker has accumulated a team-best .493 slugging percentage. He's batting .269 with an on-base percentage of .339.
• He ranks 40th in batting average, 53rd in on-base percentage and 22nd in slugging percentage among all qualifying hitters in MLB.
• Rooker enters this game on a five-game hitting streak. During his last five outings he is hitting .400 with two doubles, two home runs, two walks and three RBIs.
• Tyler Soderstrom has 31 doubles, a triple, 24 home runs and 52 walks while batting .278. He's slugging .478 with an on-base percentage of .349.
• Including all qualified players, he is 25th in batting average, 39th in on-base percentage and 34th in slugging percentage.
• Nick Kurtz has 24 doubles, two triples, 32 home runs and 59 walks while batting .296.
• Shea Langeliers' 118 hits pace his team.

Red Sox vs Athletics Head to Head

• 9/16/2025: 2-1 OAK (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/10/2025: 5-4 OAK (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/9/2025: 6-0 BOS (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/8/2025: 7-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/11/2024: 7-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 7/10/2024: 5-2 OAK (Favorite: Red Sox, Spread: -1.5, Total: 10, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 7/9/2024: 12-9 BOS (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/3/2024: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/2/2024: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/1/2024: 9-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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