Rays vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 2:12 a.m.

The Tampa Bay Rays versus the Boston Red Sox is on the MLB schedule for Saturday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Rays vs Red Sox Game Info

• Tampa Bay Rays (75-79) vs. Boston Red Sox (84-70)
• Date: Saturday, September 20, 2025
• Time: 7:05 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and NESN

Rays vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-112) | BOS: (-104)
• Spread: TB: +1.5 (-192) | BOS: -1.5 (+158)
• Total: 8 -- Over: (-120) | Under: (-102)

Rays vs Red Sox Probable Starting Pitchers

Probable Pitchers: Adrian Houser (Rays) - 8-4, 3.11 ERA vs Kyle Harrison (Red Sox) - 1-1, 4.05 ERA

The probable starters are Adrian Houser (8-4) for the Rays and Kyle Harrison (1-1) for the Red Sox. Houser's team is 12-6-0 against the spread in his starts this season. Houser has started five games with his team as the moneyline favorite and won each of them. When Harrison starts, the Red Sox have gone 2-2-0 against the spread. The Red Sox were the moneyline underdog for one Harrison start this season -- they won.

Rays vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (56.2%)

Rays vs Red Sox Moneyline

• Boston is a -104 underdog on the moneyline, while Tampa Bay is a -112 favorite at home.

Rays vs Red Sox Spread

• The Red Sox are 1.5-run favorites against the spread for this matchup with the Rays. The Red Sox are +158 to cover, while the Rays are -192 to cover as a 1.5-run underdog on the runline.

Rays vs Red Sox Over/Under

• The over/under for Rays-Red Sox on Sept. 20 is 8. The over is -120, and the under is -102.

Bet on Tampa Bay Rays vs. Boston Red Sox on FanDuel today!

Rays vs Red Sox Betting Trends

• The Rays have been chosen as favorites in 70 games this year and have walked away with the win 39 times (55.7%) in those games.
• Tampa Bay has a record of 39-30 when favored by -112 or more this year.
• The Rays and their opponents have hit the over in 65 of their 149 games with a total set by oddsmakers this season.
• In 149 games with a line this season, the Rays have a mark of 66-83-0 against the spread.
• The Red Sox have been the moneyline underdog 49 total times this season. They've gone 22-27 in those games.
• Boston is 21-25 (winning 45.7% of its games) when playing as a moneyline underdog of -104 or longer.
• The Red Sox have combined with opponents to go over the total 71 times this season for a 71-75-7 record against the over/under.
• The Red Sox have an 81-72-0 record ATS this season (covering 52.9% of the time).

Rays Player Leaders

• Junior Caminero leads Tampa Bay in total hits (149) this season while batting .259 with 72 extra-base hits. He has an on-base percentage of .302 and a slugging percentage of .537.
• Among qualifying hitters in MLB, he is 69th in batting average, 121st in on-base percentage, and eighth in slugging.
• Yandy Diaz leads the Rays with an OPS of .852. He has a slash line of .300/.365/.488 this season.
• He ranks seventh in batting average, 14th in on-base percentage and 25th in slugging among qualified batters.
• Brandon Lowe is batting .258 with a .474 slugging percentage and 80 RBI this year.
• Lowe has recorded a hit in two games in a row. In his last five games he is batting .217 with a double, a home run and six RBIs.
• Chandler Simpson has been key for Tampa Bay with 116 hits, an OBP of .333 plus a slugging percentage of .352.
• Simpson takes a four-game hitting streak into this game. During his last five outings he is hitting .444 with three doubles, a walk and three RBIs.

Red Sox Player Leaders

• Jarren Duran has accumulated an on-base percentage of .335, a slugging percentage of .452, and has 154 hits, all club-highs for the Red Sox (while batting .261).
• Including all qualified hitters, he is 61st in batting average, while his on-base percentage ranks 61st and he is 57th in slugging.
• Trevor Story's .442 slugging percentage paces his team. He has a batting average of .265 with an on-base percentage of .311.
• He is currently 51st in batting average, 110th in on-base percentage and 63rd in slugging percentage among all qualifying hitters.
• Alex Bregman is batting .273 with 27 doubles, 18 home runs and 47 walks.
• Ceddanne Rafaela is batting .243 with 30 doubles, three triples, 16 home runs and 25 walks.

Rays vs Red Sox Head to Head

• 9/19/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/13/2025: 4-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/12/2025: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/11/2025: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/10/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/11/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/10/2025: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 10-8 TB (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/16/2025: 1-0 BOS (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/15/2025: 7-4 BOS (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!