Rays vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 6:13 p.m.

The MLB slate on Saturday includes the Tampa Bay Rays taking on the Boston Red Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Rays vs Red Sox Game Info

• Tampa Bay Rays (75-79) vs. Boston Red Sox (84-70)
• Date: Saturday, September 20, 2025
• Time: 7:05 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and NESN

Rays vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-112) | BOS: (-104)
• Spread: TB: +1.5 (-192) | BOS: -1.5 (+158)
• Total: 8 -- Over: (-102) | Under: (-120)

Rays vs Red Sox Probable Starting Pitchers

Probable Pitchers: Adrian Houser (Rays) - 8-4, 3.11 ERA vs Kyle Harrison (Red Sox) - 1-1, 4.05 ERA

The Rays will give the nod to Adrian Houser (8-4, 3.11 ERA), who is eyeing win No. 9 on the season, and the Red Sox will counter with Kyle Harrison (1-1, 4.05 ERA). Houser and his team have a record of 12-6-0 against the spread when he starts. Houser's team has won each of the five games he's started as the moneyline favorite. The Red Sox have gone 2-2-0 against the spread when Harrison starts. The Red Sox were named the moneyline underdog for one Harrison start this season -- they won.

Rays vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (56.3%)

Rays vs Red Sox Moneyline

• Looking at the moneyline for Red Sox-Rays, Boston is the underdog at -104, and Tampa Bay is -112 playing at home.

Rays vs Red Sox Spread

• The Red Sox are 1.5-run favorites against the spread for this matchup with the Rays. The Red Sox are +158 to cover, while the Rays are -192 to cover as a 1.5-run underdog on the runline.

Rays vs Red Sox Over/Under

• The over/under for the Rays versus Red Sox game on Sept. 20 has been set at 8, with -102 odds on the over and -120 odds on the under.

Bet on Tampa Bay Rays vs. Boston Red Sox on FanDuel today!

Rays vs Red Sox Betting Trends

• The Rays have been victorious in 39, or 55.7%, of the 70 contests they have been chosen as favorites in this season.
• This year Tampa Bay has won 39 of 69 games when listed as at least -112 on the moneyline.
• Contests with the Rays have gone over the total set by oddsmakers in 65 of 149 chances this season.
• The Rays have an against the spread record of 66-83-0 in 149 games with a line this season.
• The Red Sox have been the underdog on the moneyline 49 total times this season. They've gone 22-27 in those games.
• Boston is 21-25 (winning 45.7% of its games) when playing as a moneyline underdog of -104 or longer.
• The Red Sox have played in 153 games with a set over/under, and have combined with their opponents to go over the total 71 times (71-75-7).
• The Red Sox have an 81-72-0 record ATS this season (covering 52.9% of the time).

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 149 hits, batting .259 this season with 72 extra-base hits. He has an on-base percentage of .302 and a slugging percentage of .537.
• Among all qualified batters in baseball, his batting average ranks 68th, his on-base percentage ranks 121st, and he is eighth in slugging.
• Yandy Diaz leads the Rays with an OPS of .852. He has a slash line of .300/.365/.488 this season.
• Among qualifying batters, his batting average ranks him seventh, his on-base percentage 14th, and his slugging percentage 25th.
• Brandon Lowe has 125 hits this season and has a slash line of .258/.308/.474.
• Lowe brings a two-game hitting streak into this game. In his last five games he is batting .217 with a double, a home run and six RBIs.
• Chandler Simpson has been key for Tampa Bay with 116 hits, an OBP of .333 plus a slugging percentage of .352.
• Simpson enters this game on a four-game hitting streak. During his last five outings he is hitting .444 with three doubles, a walk and three RBIs.

Red Sox Player Leaders

• Jarren Duran has racked up a team-best OBP (.335) and slugging percentage (.452), while pacing the Red Sox in hits (154, while batting .261).
• He is 61st in batting average, 62nd in on-base percentage and 57th in slugging percentage among all qualified batters in the majors.
• Trevor Story leads his team with a .442 slugging percentage. He has a batting average of .265 with an on-base percentage of .311.
• He is currently 50th in batting average, 110th in on-base percentage and 63rd in slugging percentage among all qualified hitters.
• Alex Bregman is hitting .273 with 27 doubles, 18 home runs and 47 walks.
• Ceddanne Rafaela is batting .243 with 30 doubles, three triples, 16 home runs and 25 walks.

Rays vs Red Sox Head to Head

• 9/19/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/13/2025: 4-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/12/2025: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/11/2025: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/10/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/11/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/10/2025: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 10-8 TB (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/16/2025: 1-0 BOS (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/15/2025: 7-4 BOS (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

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