Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 2:12 a.m.

MLB action on Saturday includes the San Diego Padres playing the Chicago White Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Padres vs White Sox Game Info

• San Diego Padres (83-71) vs. Chicago White Sox (58-96)
• Date: Saturday, September 20, 2025
• Time: 7:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SDPA

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-172) | CHW: (+144)
• Spread: SD: -1.5 (-102) | CHW: +1.5 (-118)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 4-5, 5.63 ERA vs Yoendrys Gomez (White Sox) - 3-2, 4.91 ERA

This contest's pitching matchup is set, as the Padres will send Yu Darvish (4-5) to the mound, while Yoendrys Gomez (3-2) will answer the bell for the White Sox. Darvish's team is 8-4-0 against the spread this season in his starts. Darvish's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 4-2. The White Sox have a 6-1-0 ATS record in Gomez's seven starts that had a set spread. The White Sox have been the moneyline underdog in seven of Gomez's starts this season, and they went 4-3 in those matchups.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (62.3%)

Padres vs White Sox Moneyline

• The Padres vs White Sox moneyline has San Diego as a -172 favorite, while Chicago is a +144 underdog at home.

Padres vs White Sox Spread

• The White Sox are +1.5 on the run line against the Padres. The White Sox are -118 to cover, and the Padres are -102.

Padres vs White Sox Over/Under

• Padres versus White Sox, on Sept. 20, has an over/under of 8.5, with the over being -105 and the under -115.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have been chosen as favorites in 83 games this year and have walked away with the win 49 times (59%) in those games.
• San Diego has a record of 18-12 in contests when sportsbooks favor them by -172 or more on the moneyline.
• The Padres' games have gone over the total in 66 of their 152 opportunities.
• The Padres are 81-71-0 against the spread in their 152 games that had a posted line this season.
• The White Sox are 54-91 in games they were the underdog on the moneyline (winning 37.2% of those games).
• Chicago has gone 24-48 when playing as a moneyline underdog with odds of +144 or longer (33.3%).
• In the 149 games bookmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 68 times (68-73-8).
• The White Sox have an 85-64-0 record ATS this season (covering 57% of the time).

Padres Player Leaders

• Fernando Tatis Jr. is hitting .266 with 27 doubles, two triples, 22 home runs and 88 walks. He has an on-base percentage of .368 and a slugging percentage of .435.
• Among qualifying hitters in MLB, his batting average ranks 48th, his on-base percentage ranks 13th, and he is 71st in slugging.
• Tatis has picked up at least one hit in three games in a row. During his last five outings he is batting .421 with three walks.
• Manny Machado leads San Diego in total hits (164) this season while batting .277 with 59 extra-base hits. He's slugging .465 with an on-base percentage of .337.
• His batting average ranks 30th among qualified players, his on-base percentage 56th, and his slugging percentage 45th.
• Luis Arraez has hit seven homers with a team-high .385 SLG this season.
• Arraez has picked up a hit in eight straight games. During his last 10 outings he is batting .324 with a walk and three RBIs.
• Ramon Laureano is batting .285 with a .346 OBP and 76 RBI for San Diego this season.

White Sox Player Leaders

• Miguel Vargas has put up a team-high .309 on-base percentage. He's batting .228 and slugging .397.
• Including all qualified hitters, he ranks 134th in batting average, while his on-base percentage ranks 112th and he is 106th in slugging.
• Andrew Benintendi has 16 doubles, two triples, 20 home runs and 39 walks while batting .240. He's slugging .431 with an on-base percentage of .306.
• Lenyn Sosa has accumulated a team-best slugging percentage (.424) and leads the White Sox in hits (128).
• Chase Meidroth is hitting .267 with 15 doubles, five home runs and 44 walks.

Padres vs White Sox Head to Head

• 9/19/2025: 4-3 CHW (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/22/2024: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -350, Underdog Moneyline: +280)
• 9/21/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/20/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 10/1/2023: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/30/2023: 6-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/29/2023: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 10/2/2022: 2-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2022: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/30/2022: 3-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)

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