Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 6:12 p.m.

On Saturday in MLB, the San Diego Padres are up against the Chicago White Sox.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs White Sox Game Info

• San Diego Padres (83-71) vs. Chicago White Sox (58-96)
• Date: Saturday, September 20, 2025
• Time: 7:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SDPA

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-180) | CHW: (+152)
• Spread: SD: -1.5 (-104) | CHW: +1.5 (-115)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 4-5, 5.63 ERA vs Yoendrys Gomez (White Sox) - 3-2, 4.91 ERA

The Padres will call on Yu Darvish (4-5) versus the White Sox and Yoendrys Gomez (3-2). Darvish's team is 8-4-0 against the spread in his starts this season. Darvish's team has a record of 4-2 this season when he starts and they are the favorite on the moneyline. The White Sox have gone 6-1-0 ATS in Gomez's seven starts that had a set spread. The White Sox are 4-3 in Gomez's seven starts this season that they were the underdog on the moneyline.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (63.4%)

Padres vs White Sox Moneyline

• San Diego is a -180 favorite on the moneyline, while Chicago is a +152 underdog at home.

Padres vs White Sox Spread

• The Padres are 1.5-run road favorites on the runline against the White Sox. The Padres are -104 to cover, and the White Sox are -115.

Padres vs White Sox Over/Under

• Padres versus White Sox on Sept. 20 has an over/under of 8.5 runs, with the odds on the over -105 and the under set at -115.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have been victorious in 49, or 59%, of the 83 contests they have been chosen as favorites in this season.
• This season San Diego has been victorious 16 times in 25 chances when named as a favorite of at least -180 on the moneyline.
• The Padres' games have gone over the total in 66 of their 152 opportunities.
• In 152 games with a line this season, the Padres have a mark of 81-71-0 against the spread.
• The White Sox have won 54 of the 145 games they were the underdog on the moneyline this season (37.2%).
• When playing as a moneyline underdog with odds of +152 or longer, Chicago has a 19-43 record (winning only 30.6% of its games).
• In the 149 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 68 times (68-73-8).
• The White Sox have covered 57% of their games this season, going 85-64-0 ATS.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 22 home runs and 88 walks while batting .266. He has an on-base percentage of .368 and a slugging percentage of .435.
• Among qualifying hitters in MLB, he is 47th in batting average, 13th in on-base percentage, and 72nd in slugging.
• Tatis has recorded a base hit in three games in a row. In his last five games he is batting .421 with three walks.
• Manny Machado leads San Diego with 164 hits. He is batting .277 this season and has 59 extra-base hits. He's also slugging .465 with an on-base percentage of .337.
• His batting average ranks 31st among qualified players, his on-base percentage 57th, and his slugging percentage 47th.
• Luis Arraez has an OPS of .706, fueled by an OBP of .321 and a team-best slugging percentage of .385 this season.
• Arraez has logged a hit or more in eight straight games. During his last 10 outings he is hitting .324 with a walk and three RBIs.
• Ramon Laureano has been key for San Diego with 122 hits, an OBP of .346 plus a slugging percentage of .523.

White Sox Player Leaders

• Miguel Vargas has accumulated an on-base percentage of .309, a team-high for the White Sox. He's batting .228 and slugging .397.
• Including all qualifying hitters, he ranks 134th in batting average, while his on-base percentage is 112th and he is 106th in slugging.
• Andrew Benintendi is batting .240 with 16 doubles, two triples, 20 home runs and 39 walks. He's slugging .431 with an on-base percentage of .306.
• Lenyn Sosa has racked up a team-high slugging percentage (.424) and leads the White Sox in hits (128).
• Chase Meidroth is batting .267 with 15 doubles, five home runs and 44 walks.

Padres vs White Sox Head to Head

• 9/19/2025: 4-3 CHW (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/22/2024: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -350, Underdog Moneyline: +280)
• 9/21/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/20/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 10/1/2023: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/30/2023: 6-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/29/2023: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 10/2/2022: 2-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2022: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/30/2022: 3-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)

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