Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 4:13 a.m.

The Milwaukee Brewers will take on the St. Louis Cardinals in MLB action on Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (94-60) vs. St. Louis Cardinals (75-79)
• Date: Saturday, September 20, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSWI

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-138) | STL: (+118)
• Spread: MIL: -1.5 (+112) | STL: +1.5 (-134)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Chad Patrick (Brewers) - 3-8, 3.64 ERA vs Miles Mikolas (Cardinals) - 8-10, 4.80 ERA

The Brewers will give the nod to Chad Patrick (3-8) against the Cardinals and Miles Mikolas (8-10). When Patrick starts, his team is 6-13-0 against the spread this season. Patrick's team is 3-7 this season when he starts and they are the moneyline favorite. The Cardinals have a 13-16-0 ATS record in Mikolas' 29 starts with a set spread. The Cardinals are 9-12 in Mikolas' 21 starts this season that they were the moneyline underdog.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (58.6%)

Brewers vs Cardinals Moneyline

• The Brewers vs Cardinals moneyline has Milwaukee as a -138 favorite, while St. Louis is a +118 underdog at home.

Brewers vs Cardinals Spread

• The Brewers are favored by 1.5 runs on the road against the Cardinals. The Brewers are +112 to cover the spread, while the Cardinals are -134.

Brewers vs Cardinals Over/Under

• A combined run total of 8.5 has been set for Brewers-Cardinals on Sept. 20, with the over at -120 and the under at -102.

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Brewers vs Cardinals Betting Trends

• The Brewers have come away with 58 wins in the 89 contests they have been listed as the favorites in this season.
• Milwaukee has a record of 36-13 when favored by -138 or more this year.
• The Brewers and their opponents have gone over in 77 of their 151 games with a total set by sportsbooks this season.
• The Brewers have posted a record of 85-66-0 against the spread this season.
• The Cardinals have won 48.2% of the games this season they were the underdog on the moneyline (40-43).
• St. Louis is 17-26 (winning just 39.5% of its games) when it has played as a moneyline underdog of +118 or longer.
• The Cardinals have combined with opponents to go over the total 76 times this season for a 76-67-5 record against the over/under.
• The Cardinals have collected a 74-74-0 record against the spread this season (covering 50% of the time).

Brewers Player Leaders

• William Contreras has 27 doubles, 17 home runs and 82 walks while batting .264. He has an on-base percentage of .359 and a slugging percentage of .406.
• Among the qualifying hitters in the majors, his batting average ranks 55th, his on-base percentage ranks 23rd, and he is 94th in slugging.
• Brice Turang leads Milwaukee in slugging percentage (.438) thanks to 46 extra-base hits. He's batting .287 with an on-base percentage of .357.
• His batting average ranks 16th among qualified players, his on-base percentage 25th, and his slugging percentage 69th.
• Christian Yelich has 146 hits this season and has a slash line of .269/.346/.466.
• Yelich enters this matchup with two games in a row with at least one hit. During his last five outings he is hitting .381 with two doubles, a home run, a walk and four RBIs.
• Jackson Chourio leads Milwaukee in total hits (143) this season while batting .278 with 58 extra-base hits.
• Chourio brings a two-game hitting streak into this game. In his last five games he is batting .182 with a double, a walk and an RBI.

Cardinals Player Leaders

• Alec Burleson has a slugging percentage of .466 and has 136 hits, both team-best marks for the Cardinals. He's batting .289 and with an on-base percentage of .342.
• Including all the qualifying hitters in the big leagues, he is 13th in batting average, 50th in on-base percentage and 43rd in slugging percentage.
• Burleson enters this matchup on a four-game hitting streak. In his last five games he is hitting .471 with three doubles, a home run, two walks and three RBIs.
• Brendan Donovan's .351 OBP paces his team. He has a batting average of .283 while slugging .410.
• He ranks 20th in batting average, 35th in on-base percentage and 90th in slugging percentage in the big leagues.
• Lars Nootbaar is hitting .237 with 23 doubles, a triple, 13 home runs and 59 walks.
• Ivan Herrera is batting .280 with 13 doubles, 16 home runs and 38 walks.

Brewers vs Cardinals Head to Head

• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)

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