Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 7:12 p.m.

On Saturday in MLB, the Milwaukee Brewers are playing the St. Louis Cardinals.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (94-60) vs. St. Louis Cardinals (75-79)
• Date: Saturday, September 20, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSWI

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-118) | STL: (-100)
• Spread: MIL: -1.5 (+136) | STL: +1.5 (-164)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Chad Patrick (Brewers) - 3-8, 3.64 ERA vs Miles Mikolas (Cardinals) - 8-10, 4.80 ERA

The Brewers will look to Chad Patrick (3-8) against the Cardinals and Miles Mikolas (8-10). Patrick and his team are 6-13-0 ATS this season when he starts. Patrick's team is 3-7 this season when he starts and they are the moneyline favorite. The Cardinals have a 13-16-0 record against the spread in Mikolas' starts. The Cardinals have been the underdog on the moneyline in 21 of Mikolas' starts this season, and they went 9-12 in those matchups.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (57.4%)

Brewers vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Brewers, St. Louis is the underdog at -100, and Milwaukee is -118 playing on the road.

Brewers vs Cardinals Spread

• The Brewers are at the Cardinals and are favored by 1.5 runs (+136 to cover) on the runline. St. Louis is -164 to cover.

Brewers vs Cardinals Over/Under

• A combined run total of 7.5 has been set for Brewers-Cardinals on Sept. 20, with the over at -112 and the under at -108.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have been chosen as favorites in 89 games this year and have walked away with the win 58 times (65.2%) in those games.
• This year Milwaukee has won 53 of 79 games when listed as at least -118 on the moneyline.
• The Brewers' games have gone over the total in 77 of their 151 opportunities.
• The Brewers have posted a record of 85-66-0 against the spread this season.
• The Cardinals have won 48.2% of the games this season they were the underdog on the moneyline (40-43).
• When it has played as a moneyline underdog with odds of -100 or longer, St. Louis has gone 27-38 (41.5%).
• The Cardinals have had an over/under set by bookmakers 148 times, and have combined with opponents to go over the total in 76 of those games (76-67-5).
• The Cardinals have collected a 74-74-0 record against the spread this season (covering 50% of the time).

Brewers Player Leaders

• William Contreras is batting .264 with 27 doubles, 17 home runs and 82 walks. He has an on-base percentage of .359 and a slugging percentage of .406.
• Among qualified hitters in baseball, he ranks 55th in batting average, 23rd in on-base percentage, and 93rd in slugging.
• Brice Turang has hit 18 homers this season while driving in 76 runs. He's batting .287 this season and slugging .438 with an on-base percentage of .357.
• Among qualifying hitters, his batting average ranks him 16th, his on-base percentage 25th, and his slugging percentage 69th.
• Christian Yelich has collected 146 base hits, an OBP of .346 and a slugging percentage of .466 this season.
• Yelich heads into this matchup with two games in a row with at least one hit. In his last five games he is batting .381 with two doubles, a home run, a walk and four RBIs.
• Jackson Chourio leads Milwaukee in total hits (143) this season while batting .278 with 58 extra-base hits.
• Chourio heads into this game on a two-game hitting streak. During his last five outings he is batting .182 with a double, a walk and an RBI.

Cardinals Player Leaders

• Alec Burleson has put up a slugging percentage of .466 and has 136 hits, both team-high figures for the Cardinals. He's batting .289 and with an on-base percentage of .342.
• Including all the qualified hitters in the majors, he is 13th in batting average, 50th in on-base percentage and 44th in slugging percentage.
• Burleson brings a four-game hitting streak into this matchup. During his last five outings he is hitting .471 with three doubles, a home run, two walks and three RBIs.
• Brendan Donovan leads his team with a .351 on-base percentage. He has a batting average of .283 while slugging .410.
• Including all qualified hitters, he ranks 20th in batting average, 35th in on-base percentage and 90th in slugging percentage.
• Lars Nootbaar is hitting .237 with 23 doubles, a triple, 13 home runs and 59 walks.
• Ivan Herrera has 13 doubles, 16 home runs and 38 walks while batting .280.

Brewers vs Cardinals Head to Head

• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)

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