Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 2:12 a.m.

The Chicago Cubs are among the MLB squads in action on Saturday, up against the Cincinnati Reds.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Cubs vs Reds Game Info

• Chicago Cubs (88-66) vs. Cincinnati Reds (78-76)
• Date: Saturday, September 20, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-112) | CIN: (-104)
• Spread: CHC: -1.5 (+140) | CIN: +1.5 (-170)
• Total: 9 -- Over: (-112) | Under: (-108)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Javier Assad (Cubs) - 3-1, 4.23 ERA vs Zack Littell (Reds) - 9-8, 3.86 ERA

The Cubs will call on Javier Assad (3-1) versus the Reds and Zack Littell (9-8). Assad's team is 1-4-0 against the spread this season in his starts. Assad and his team have won each of the four games he's started as the moneyline favorite. The Reds have gone 15-15-0 against the spread when Littell starts. The Reds have been the underdog on the moneyline in 19 of Littell's starts this season, and they went 10-9 in those matchups.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (50.9%)

Cubs vs Reds Moneyline

• Chicago is the favorite, -112 on the moneyline, while Cincinnati is a -104 underdog despite being at home.

Cubs vs Reds Spread

• The Reds are +1.5 on the run line against the Cubs. The Reds are -170 to cover, and the Cubs are +140.

Cubs vs Reds Over/Under

• The over/under for Cubs-Reds on Sept. 20 is 9. The over is -112, and the under is -108.

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Cubs vs Reds Betting Trends

• The Cubs have been favorites in 104 games this season and have come away with the win 66 times (63.5%) in those contests.
• Chicago has a record of 66-38 in contests when bookmakers favor them by -112 or more on the moneyline.
• The Cubs and their opponents have gone over the total this season in 69 of their 150 opportunities.
• In 150 games with a line this season, the Cubs have a mark of 71-79-0 against the spread.
• The Reds have put together a 40-42 record in games they were the underdog on the moneyline (winning 48.8% of those games).
• Cincinnati is 34-40 (winning 45.9% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Reds have played in 147 games with an over/under set, and have combined with their opponents to go over the total 58 times (58-81-8).
• The Reds are 76-71-0 against the spread this season.

Cubs Player Leaders

• Nico Hoerner has an OPS of .746, fueled by an OBP of .349 and a team-best slugging percentage of .397 this season. He has a .300 batting average.
• Among the qualifying batters in baseball, his batting average ranks seventh, his on-base percentage ranks 39th, and he is 106th in slugging.
• Pete Crow-Armstrong is batting .248 with 37 doubles, four triples, 29 home runs and 29 walks. He's slugging .481 with an on-base percentage of .289.
• Among qualifying hitters, he is 95th in batting average, 136th in on-base percentage and 29th in slugging percentage.
• Ian Happ has collected 131 base hits, an OBP of .345 and a slugging percentage of .424 this season.
• Seiya Suzuki has been key for Chicago with 132 hits, an OBP of .325 plus a slugging percentage of .458.

Reds Player Leaders

• Elly De La Cruz has accumulated 157 hits with a .436 slugging percentage, both team-high figures for the Reds. He's batting .262 and with an on-base percentage of .335.
• Including all the qualifying players in MLB, his batting average is 58th, his on-base percentage ranks 61st, and he is 70th in slugging.
• TJ Friedl has a .361 OBP to pace his team. He has a batting average of .257 while slugging .367.
• His batting average is 73rd among all qualified players, his on-base percentage is 18th, and he is 134th in slugging.
• Spencer Steer has 20 doubles, two triples, 20 home runs and 46 walks while batting .243.
• Austin Hays is hitting .269 with 16 doubles, five triples, 15 home runs and 29 walks.

Cubs vs Reds Head to Head

• 9/19/2025: 7-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/18/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/6/2025: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 5-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2025: 3-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/31/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/30/2025: 6-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/25/2025: 11-8 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/24/2025: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

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