Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 6:12 p.m.

The MLB's Saturday slate includes the Cincinnati Reds facing the Chicago Cubs.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Reds vs Cubs Game Info

• Cincinnati Reds (78-76) vs. Chicago Cubs (88-66)
• Date: Saturday, September 20, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and MARQ

Reds vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-112) | CHC: (-104)
• Spread: CIN: +1.5 (-196) | CHC: -1.5 (+162)
• Total: 9 -- Over: (-108) | Under: (-112)

Reds vs Cubs Probable Starting Pitchers

Probable Pitchers: Zack Littell (Reds) - 9-8, 3.86 ERA vs Javier Assad (Cubs) - 3-1, 4.23 ERA

The Reds will call on Zack Littell (9-8) versus the Cubs and Javier Assad (3-1). When Littell starts, his team is 15-15-0 against the spread this season. When Littell starts a game and his team is the favorite on the moneyline, they have a record of 5-5. The Cubs are 1-4-0 ATS in Assad's five starts that had a set spread. The Cubs were named the moneyline underdog for one Assad start this season -- they lost.

Reds vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (51.3%)

Reds vs Cubs Moneyline

• Cincinnati is the favorite, -112 on the moneyline, while Chicago is a -104 underdog on the road.

Reds vs Cubs Spread

• The Cubs are 1.5-run favorites against the spread for this matchup with the Reds. The Cubs are +162 to cover, while the Reds are -196 to cover as a 1.5-run underdog on the runline.

Reds vs Cubs Over/Under

• Reds versus Cubs on Sept. 20 has an over/under of 9 runs, with the odds on the over -108 and the under set at -112.

Bet on Cincinnati Reds vs. Chicago Cubs on FanDuel today!

Reds vs Cubs Betting Trends

• The Reds have been favorites in 62 games this season and have come away with the win 33 times (53.2%) in those contests.
• Cincinnati has a record of 30-28 in contests when sportsbooks favor them by -112 or more on the moneyline.
• The Reds and their opponents have gone over the total this season in 58 of their 147 opportunities.
• The Reds are 76-71-0 against the spread in their 147 games with a line set by sportsbooks this season.
• The Cubs have won 18 of the 42 games they were the underdog on the moneyline this season (42.9%).
• Chicago has a 16-20 record (winning 44.4% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Cubs have played in 150 games with a set over/under, and have combined with opponents to go over the total 69 times (69-71-10).
• The Cubs have collected a 71-79-0 record against the spread this season.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.436) and total hits (157) this season. He's batting .262 with an on-base percentage of .335.
• He is 58th in batting average, 62nd in on-base percentage, and 71st in slugging among all qualifying hitters in the majors.
• TJ Friedl leads Cincinnati with an OBP of .361 this season while batting .257 with 76 walks and 77 runs scored. He's slugging .367.
• Among qualifying hitters, his batting average places him 74th, his on-base percentage 18th, and his slugging percentage 134th.
• Spencer Steer has collected 117 base hits, an OBP of .313 and a slugging percentage of .417 this season.
• Austin Hays is batting .269 with a .318 OBP and 64 RBI for Cincinnati this season.
• Hays has safely hit in four straight games. During his last five outings he is batting .333 with a double and a walk.

Cubs Player Leaders

• Nico Hoerner has put up a team-best .397 slugging percentage. He's batting .300 with an on-base percentage of .349.
• Including all qualifying hitters, he is seventh in batting average, while his on-base percentage ranks 39th and he is 106th in slugging.
• Pete Crow-Armstrong has 37 doubles, four triples, 29 home runs and 29 walks while hitting .248. He's slugging .481 with an on-base percentage of .289.
• Including all qualifying hitters, he is 95th in batting average, 136th in on-base percentage and 29th in slugging percentage.
• Ian Happ has 29 doubles, 23 home runs and 85 walks while batting .243.
• Seiya Suzuki has 30 doubles, three triples, 27 home runs and 69 walks while hitting .243.

Reds vs Cubs Head to Head

• 9/19/2025: 7-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/18/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/6/2025: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 5-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2025: 3-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/31/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/30/2025: 6-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/25/2025: 11-8 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/24/2025: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

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