Rays vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 6:13 p.m.

The MLB's Tuesday schedule includes the Tampa Bay Rays facing the Baltimore Orioles.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Rays vs Orioles Game Info

• Tampa Bay Rays (76-80) vs. Baltimore Orioles (73-83)
• Date: Tuesday, September 23, 2025
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN2 and FDSSUN

Rays vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-110) | BAL: (-106)
• Spread: TB: -1.5 (+150) | BAL: +1.5 (-182)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Rays vs Orioles Probable Starting Pitchers

Probable Pitchers: Ryan Pepiot (Rays) - 11-11, 3.77 ERA vs Dean Kremer (Orioles) - 10-10, 4.39 ERA

The probable starters are Ryan Pepiot (11-11) for the Rays and Dean Kremer (10-10) for the Orioles. Pepiot's team is 11-18-0 against the spread this season in his starts. When Pepiot starts a game and his team is the favorite on the moneyline, they have a record of 9-6. The Orioles are 14-14-0 against the spread when Kremer starts. The Orioles have a 7-9 record in Kremer's 16 starts this season when they were the underdog on the moneyline.

Rays vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (51.8%)

Rays vs Orioles Moneyline

• Baltimore is the underdog, -106 on the moneyline, while Tampa Bay is a -110 favorite despite being on the road.

Rays vs Orioles Spread

• The Orioles are hosting the Rays, and are +1.5 on the runline. The Orioles are +150 to cover the spread, and the Rays are -182.

Rays vs Orioles Over/Under

• The over/under for Rays-Orioles on Sept. 23 is 8.5. The over is -115, and the under is -105.

Bet on Tampa Bay Rays vs. Baltimore Orioles on FanDuel today!

Rays vs Orioles Betting Trends

• The Rays have been favorites in 71 games this season and have come away with the win 39 times (54.9%) in those contests.
• This year Tampa Bay has won 39 of 71 games when listed as at least -110 on the moneyline.
• Contests with the Rays have gone over the total set by sportsbooks in 67 of 151 chances this season.
• The Rays have posted a record of 67-84-0 against the spread this season.
• The Orioles have gone 40-49 in games they were listed as the moneyline underdog (winning 44.9% of those games).
• Baltimore has a 38-49 record (winning 43.7% of its games) when it has played as a moneyline underdog of -106 or longer.
• The Orioles have played in 153 games with an over/under set, and have combined with opponents to go over the total 63 times (63-86-4).
• The Orioles have collected a 73-80-0 record ATS this season (covering 47.7% of the time).

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 151 hits, batting .260 this season with 72 extra-base hits. He has an on-base percentage of .304 and a slugging percentage of .535.
• Among all qualifying hitters in MLB, his batting average ranks 62nd, his on-base percentage ranks 117th, and he is eighth in slugging.
• Yandy Diaz is slashing .302/.368/.488 this season and leads the Rays with an OPS of .856.
• Among qualifiers, he is seventh in batting average, 12th in on-base percentage and 21st in slugging percentage.
• Diaz takes a three-game streak with at least one hit into this one. During his last five outings he is batting .533 with a double, a home run, six walks and three RBIs.
• Brandon Lowe has collected 127 base hits, an OBP of .309 and a slugging percentage of .478 this season.
• Lowe has recorded a hit in four straight games. In his last five games he is batting .238 with two home runs, a walk and six RBIs.
• Chandler Simpson has no home runs, but 26 RBI and a batting average of .299 this season.

Orioles Player Leaders

• Gunnar Henderson has racked up a team-best OBP (.348) and slugging percentage (.437), while leading the Orioles in hits (152, while batting .273).
• Including all qualified hitters in the big leagues, he ranks 35th in batting average, 41st in on-base percentage and 66th in slugging percentage.
• Jackson Holliday has 21 doubles, three triples, 17 home runs and 53 walks while hitting .247. He's slugging .383 with an on-base percentage of .316.
• Including all qualified hitters, he is 96th in batting average, 99th in on-base percentage and 119th in slugging percentage.
• Jordan Westburg is batting .260 with nine doubles, a triple, 15 home runs and 17 walks.
• Adley Rutschman is batting .227 with 16 doubles, a triple, nine home runs and 37 walks.

Rays vs Orioles Head to Head

• 7/20/2025: 5-3 BAL (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/19/2025: 4-3 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/18/2025: 11-1 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/29/2025: 5-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/28/2025: 11-3 TB (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/27/2025: 22-8 BAL (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/19/2025: 4-1 BAL (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/18/2025: 12-8 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/17/2025: 5-1 BAL (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/16/2025: 7-1 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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