Pirates vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 2:12 a.m.

The Pittsburgh Pirates are among the MLB teams in action on Friday, versus the Cincinnati Reds.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Pirates vs Reds Game Info

• Pittsburgh Pirates (16-16) vs. Cincinnati Reds (20-11)
• Date: Friday, May 1, 2026
• Time: 6:45 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: Apple TV+

Pirates vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-136) | CIN: (+116)
• Spread: PIT: -1.5 (+146) | CIN: +1.5 (-176)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Pirates vs Reds Probable Starting Pitchers

Probable Pitchers: Mitch Keller (Pirates) - 2-1, 3.18 ERA vs Brady Singer (Reds) - 2-1, 4.97 ERA

The Pirates will give the nod to Mitch Keller (2-1) versus the Reds and Brady Singer (2-1). Keller's team is 3-3-0 against the spread this season in his starts. Keller's team is 1-1 this season when he starts and they're favored on the moneyline. The Reds have a 5-1-0 ATS record in Singer's six starts that had a set spread. The Reds are 4-1 in Singer's five starts this season that they were the underdog on the moneyline.

Pirates vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (50.9%)

Pirates vs Reds Moneyline

• Cincinnati is a +116 underdog on the moneyline, while Pittsburgh is a -136 favorite at home.

Pirates vs Reds Spread

• The Reds are +1.5 on the spread (-176 to cover), and Pittsburgh is +146 to cover the runline.

Pirates vs Reds Over/Under

• Pirates versus Reds, on May 1, has an over/under of 8.5, with the over being -104 and the under -118.

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Pirates vs Reds Betting Trends

• The Pirates have been chosen as favorites in 19 games this year and have walked away with the win 11 times (57.9%) in those games.
• This season Pittsburgh has come away with a win four times in nine chances when named as a favorite of at least -136 on the moneyline.
• The Pirates and their opponents have gone over in 18 of their 32 games with a total set by sportsbooks this season.
• The Pirates are 17-15-0 against the spread in their 32 games that had a posted line this season.
• The Reds have won 70% of the games this season they were the underdog on the moneyline (14-6).
• When playing as a moneyline underdog with odds of +116 or longer, Cincinnati has gone 4-3 (57.1%).
• The Reds have played in 31 games with a set over/under, and have combined with their opponents to go over the total 19 times (19-11-1).
• The Reds are 19-12-0 against the spread this season.

Pirates Player Leaders

• Oneil Cruz is batting .256 with five doubles, nine home runs and 11 walks. He has an on-base percentage of .321 and a slugging percentage of .512.
• Among all qualifying hitters in MLB, he is 73rd in batting average, 106th in on-base percentage, and 26th in slugging.
• Ryan O'Hearn is slashing .306/.394/.481 this season and leads the Pirates with an OPS of .875.
• He ranks 20th in batting average, 18th in on-base percentage and 42nd in slugging among qualifying batters.
• Brandon Lowe leads Pittsburgh with 27 hits. He is batting .252 this season and 16 of his hits have gone for extra bases.
• Lowe brings a three-game hitting streak into this game. During his last five outings he is hitting .278 with three doubles, a home run, a walk and an RBI.
• Bryan Reynolds has three home runs, 19 RBI and a batting average of .246 this season.

Reds Player Leaders

• Sal Stewart has put up a team-best OBP (.373), while leading the Reds in hits (32). He's batting .281 and slugging.
• Including all qualified hitters in the majors, his batting average places him 45th, his on-base percentage is 32nd, and he is 11th in slugging.
• Elly De La Cruz's .565 slugging percentage leads his team. He has a batting average of .282 with an on-base percentage of .355.
• Including all qualified hitters, he ranks 43rd in batting average, 55th in on-base percentage and 13th in slugging percentage.
• Nathaniel Lowe is hitting .288 with four doubles, five home runs and seven walks.
• Spencer Steer is batting .237 with six doubles, five home runs and nine walks.

Pirates vs Reds Head to Head

• 4/1/2026: 8-3 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 8-3 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2026: 2-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/24/2025: 4-3 PIT (Favorite: Reds, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/23/2025: 4-2 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/10/2025: 14-8 CIN (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/9/2025: 2-1 CIN (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/8/2025: 3-2 PIT (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/7/2025: 7-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 3-1 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)

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