Pirates vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 2:12 a.m.

The Wednesday schedule in MLB includes a matchup between the Pittsburgh Pirates and the Baltimore Orioles.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Orioles Game Info

• Pittsburgh Pirates (64-81) vs. Baltimore Orioles (67-77)
• Date: Wednesday, September 10, 2025
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SportsNet PT

Pirates vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-148) | BAL: (+126)
• Spread: PIT: -1.5 (+118) | BAL: +1.5 (-142)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Pirates vs Orioles Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 10-9, 1.98 ERA vs Tyler Wells (Orioles) - 1-0, 3.60 ERA

The Pirates will look to Paul Skenes (10-9) against the Orioles and Tyler Wells (1-0). Skenes and his team are 15-14-0 ATS this season when he starts. When Skenes starts a game and his team is the favorite on the moneyline, they have a record of 11-7. Wells has started only one game with a set spread, which the Orioles covered. The Orioles were the underdog on the moneyline for one Wells start this season -- they won.

Pirates vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (60%)

Pirates vs Orioles Moneyline

• The Pirates vs Orioles moneyline has Pittsburgh as a -148 favorite, while Baltimore is a +126 underdog at home.

Pirates vs Orioles Spread

• The Pirates are favored by 1.5 runs on the road against the Orioles. The Pirates are +118 to cover the spread, while the Orioles are -142.

Pirates vs Orioles Over/Under

• The over/under for the Pirates versus Orioles contest on Sept. 10 has been set at 7.5, with -105 odds on the over and -115 odds on the under.

Bet on Pittsburgh Pirates vs. Baltimore Orioles on FanDuel today!

Pirates vs Orioles Betting Trends

• The Pirates have come away with 19 wins in the 36 contests they have been listed as the favorites in this season.
• Pittsburgh has a record of 8-4 when favored by -148 or more this year.
• The Pirates and their opponents have gone over in 54 of their 137 games with a total set by sportsbooks this season.
• In 137 games with a line this season, the Pirates have a mark of 75-62-0 against the spread.
• The Orioles are 37-43 in games they were listed as the moneyline underdog (winning 46.2% of those games).
• When it has played as a moneyline underdog with odds of +126 or longer, Baltimore has a 10-17 record (winning only 37% of its games).
• The Orioles have played in 141 games with an over/under set, and have combined with their opponents to go over the total 60 times (60-77-4).
• The Orioles have collected a 68-73-0 record against the spread this season (covering 48.2% of the time).

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh in slugging percentage (.408) and total hits (130) this season. He's batting .246 with an on-base percentage of .315.
• Among the qualified hitters in the majors, his batting average ranks 96th, his on-base percentage ranks 104th, and he is 91st in slugging.
• Oneil Cruz is batting .202 with 17 doubles, two triples, 19 home runs and 61 walks. He's slugging .384 with an on-base percentage of .304.
• He ranks 146th in batting average, 121st in on-base percentage and 121st in slugging among qualified hitters.
• Andrew McCutchen has 105 hits this season and a team-best OBP of .337.
• McCutchen has recorded a hit in two straight games. During his last five outings he is batting .158 with a double, a home run, a walk and two RBIs.
• Tommy Pham has been key for Pittsburgh with 92 hits, an OBP of .335 plus a slugging percentage of .391.

Orioles Player Leaders

• Gunnar Henderson has an on-base percentage of .346, a slugging percentage of .444, and has 139 hits, all club-highs for the Orioles (while batting .272).
• He is 37th in batting average, 44th in on-base percentage and 65th in slugging percentage among all qualified hitters in the majors.
• Jackson Holliday is batting .250 with 20 doubles, three triples, 17 home runs and 48 walks. He's slugging .395 with an on-base percentage of .318.
• His batting average ranks 92nd among all qualified players, his on-base percentage is 97th, and he is 110th in slugging.
• Ryan Mountcastle has 18 doubles, five home runs and 14 walks while batting .259.
• Colton Cowser is batting .206 with 12 doubles, 13 home runs and 19 walks.

Pirates vs Orioles Head to Head

• 9/9/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/7/2024: 3-2 PIT (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/6/2024: 5-4 PIT (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/5/2024: 5-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/14/2023: 4-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/13/2023: 2-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/12/2023: 6-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/7/2022: 8-1 PIT (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/6/2022: 6-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

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