Pirates vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 6:19 p.m.

On Wednesday in MLB, the Pittsburgh Pirates are playing the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Pirates vs Orioles Game Info

• Pittsburgh Pirates (64-81) vs. Baltimore Orioles (67-77)
• Date: Wednesday, September 10, 2025
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SportsNet PT

Pirates vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-154) | BAL: (+130)
• Spread: PIT: -1.5 (+118) | BAL: +1.5 (-142)
• Total: 7 -- Over: (-120) | Under: (-102)

Pirates vs Orioles Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 10-9, 1.98 ERA vs Tyler Wells (Orioles) - 1-0, 3.60 ERA

The Pirates will look to Paul Skenes (10-9) against the Orioles and Tyler Wells (1-0). Skenes and his team have a record of 15-14-0 against the spread when he starts. When Skenes starts a game and his team is the favorite on the moneyline, they have a record of 11-7. Wells has started just one game with a set spread, which the Orioles covered. The Orioles were the underdog on the moneyline for one Wells start this season -- they won.

Pirates vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (59.7%)

Pirates vs Orioles Moneyline

• Pittsburgh is the favorite, -154 on the moneyline, while Baltimore is a +130 underdog despite being at home.

Pirates vs Orioles Spread

• The Pirates are at the Orioles and are favored by 1.5 runs on the spread. The Pirates are +118 to cover the runline, with the Orioles being -142.

Pirates vs Orioles Over/Under

• The Pirates-Orioles game on Sept. 10 has been given an over/under of 7 runs. The over is set at -120 and the under at -102.

Bet on Pittsburgh Pirates vs. Baltimore Orioles on FanDuel today!

Pirates vs Orioles Betting Trends

• The Pirates have come away with 19 wins in the 36 contests they have been listed as the favorites in this season.
• Pittsburgh has a record of 8-4 when favored by -154 or more this year.
• Contests with the Pirates have gone over the total set by bookmakers in 54 of 137 chances this season.
• The Pirates have an against the spread record of 75-62-0 in 137 games with a line this season.
• The Orioles have gone 37-43 in games they were the underdog on the moneyline (winning 46.2% of those games).
• Baltimore has a 10-15 record (winning 40% of its games) when it has played as a moneyline underdog of +130 or longer.
• The Orioles have had an over/under set by oddsmakers 141 times, and have combined with opponents to go over the total in 60 of those games (60-77-4).
• The Orioles have a 68-73-0 record ATS this season.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with 130 hits and a team-best slugging percentage of .408. He's batting .246 with an on-base percentage of .315.
• Among all qualified hitters in the majors, he is 96th in batting average, 103rd in on-base percentage, and 91st in slugging.
• Oneil Cruz has 17 doubles, two triples, 19 home runs and 61 walks. He's batting .202 and slugging .384 with an on-base percentage of .304.
• Among qualifying batters, he is 146th in batting average, 121st in on-base percentage and 121st in slugging percentage.
• Andrew McCutchen leads Pittsburgh in OBP (.337) this season, fueled by 105 hits.
• McCutchen heads into this game with two games in a row with at least one hit. During his last five outings he is hitting .158 with a double, a home run, a walk and two RBIs.
• Tommy Pham has nine home runs, 50 RBI and a batting average of .261 this season.

Orioles Player Leaders

• Gunnar Henderson has accumulated a team-best OBP (.346) and slugging percentage (.444), and paces the Orioles in hits (139, while batting .272).
• Including all the qualified players in MLB, he is 37th in batting average, 44th in on-base percentage and 66th in slugging percentage.
• Jackson Holliday has 20 doubles, three triples, 17 home runs and 48 walks while hitting .250. He's slugging .395 with an on-base percentage of .318.
• Including all qualifying players, he ranks 92nd in batting average, 97th in on-base percentage and 110th in slugging percentage.
• Ryan Mountcastle has 18 doubles, five home runs and 14 walks while hitting .259.
• Colton Cowser is batting .206 with 12 doubles, 13 home runs and 19 walks.

Pirates vs Orioles Head to Head

• 9/9/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/7/2024: 3-2 PIT (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/6/2024: 5-4 PIT (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/5/2024: 5-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/14/2023: 4-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/13/2023: 2-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/12/2023: 6-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/7/2022: 8-1 PIT (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/6/2022: 6-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!