Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 6:18 p.m.

In MLB action on Wednesday, the Cleveland Guardians take on the Kansas City Royals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Royals Game Info

• Cleveland Guardians (74-70) vs. Kansas City Royals (73-72)
• Date: Wednesday, September 10, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSKC

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-110) | KC: (-106)
• Spread: CLE: +1.5 (-200) | KC: -1.5 (+164)
• Total: 8 -- Over: (-108) | Under: (-112)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Logan Allen (Guardians) - 7-11, 4.46 ERA vs Jonathan Bowlan (Royals) - 1-2, 3.57 ERA

This contest's pitching matchup is set, as the Guardians will send Logan Allen (7-11) to the mound, while Jonathan Bowlan (1-2) will take the ball for the Royals. Allen's team is 12-13-0 against the spread in his starts this season. Allen's team has a record of 6-3 this season when he starts and they are the favorite on the moneyline. Last season Bowlan pitched in one game with a spread, which his team covered. Bowlan's team was the underdog on the moneyline just one time in a game he pitched a season ago, and lost.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.9%)

Guardians vs Royals Moneyline

• Looking at the moneyline for Royals-Guardians, Kansas City is the underdog at -106, and Cleveland is -110 playing at home.

Guardians vs Royals Spread

• The Royals are 1.5-run favorites against the spread for this matchup with the Guardians. The Royals are +164 to cover, while the Guardians are -200 to cover as a 1.5-run underdog on the runline.

Guardians vs Royals Over/Under

• The Guardians-Royals contest on Sept. 10 has been given an over/under of 8 runs. The over is set at -108 and the under at -112.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have won in 36, or 63.2%, of the 57 contests they have been named as odds-on favorites in this year.
• This season Cleveland has come away with a win 36 times in 57 chances when named as a favorite of at least -110 on the moneyline.
• The Guardians and their opponents have gone over in 63 of their 141 games with a total set by sportsbooks this season.
• The Guardians have posted a record of 75-66-0 against the spread this season.
• The Royals have put together a 37-44 record in games they were listed as the moneyline underdog (winning 45.7% of those games).
• In games it has played as a moneyline underdog with odds of -106 or longer, Kansas City has gone 34-42 (44.7%).
• The Royals have combined with opponents to go over the total 60 times this season for a 60-81-2 record against the over/under.
• The Royals are 70-73-0 ATS this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 151 hits and an OBP of .360 this season. He has a .287 batting average and a slugging percentage of .510.
• Among qualified hitters in baseball, he is 17th in batting average, 21st in on-base percentage, and 16th in slugging.
• Ramirez has recorded a base hit in six games in a row. In his last 10 games he is batting .308 with three doubles, a triple, two home runs, two walks and eight RBIs.
• Steven Kwan has hit 10 homers this season while driving in 48 runs. He's batting .275 this season and slugging .379 with an on-base percentage of .335.
• Among qualifying batters, he is 32nd in batting average, 60th in on-base percentage and 127th in slugging percentage.
• Kyle Manzardo has 97 hits this season and has a slash line of .239/.323/.470.
• Manzardo heads into this game with two games in a row with at least one hit. During his last five outings he is hitting .375 with a double, a home run, four walks and four RBIs.
• Angel Martinez is batting .227 with a .264 OBP and 41 RBI for Cleveland this season.

Royals Player Leaders

• Bobby Witt Jr. has put up a team-high slugging percentage (.501) while leading the Royals in hits (161). He's batting .293 and with an on-base percentage of .351.
• Including all qualified hitters in the big leagues, he is 10th in batting average, 35th in on-base percentage and 20th in slugging percentage.
• Maikel Garcia leads his team with a .354 OBP. He has a batting average of .290 while slugging .465.
• Including all qualifying hitters, his batting average puts him 13th, his on-base percentage is 32nd, and he is 43rd in slugging.
• Vinnie Pasquantino has 24 doubles, a triple, 29 home runs and 44 walks while hitting .260.
• Salvador Perez is hitting .235 with 33 doubles, 25 home runs and 23 walks.

Guardians vs Royals Head to Head

• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/26/2025: 6-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/26/2025: 5-3 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/12/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/11/2025: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2025: 6-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 3/29/2025: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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