Blue Jays vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 6:19 p.m.

The Toronto Blue Jays will face the Houston Astros in MLB action on Wednesday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Blue Jays vs Astros Game Info

• Toronto Blue Jays (83-61) vs. Houston Astros (78-67)
• Date: Wednesday, September 10, 2025
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and SCHN

Blue Jays vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-156) | HOU: (+132)
• Spread: TOR: -1.5 (+130) | HOU: +1.5 (-156)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Blue Jays vs Astros Probable Starting Pitchers

Probable Pitchers: José Berrios (Blue Jays) - 9-5, 4.02 ERA vs Jason Alexander (Astros) - 4-1, 4.68 ERA

The Blue Jays will call on Jose Berrios (9-5) against the Astros and Jason Alexander (4-1). Berrios and his team have a record of 17-11-0 against the spread when he starts. Berrios' team has won 60% of his starts when they are favored on the moneyline (9-6). The Astros have a 6-3-0 ATS record in Alexander's nine starts with a set spread. The Astros won each of Alexander's four starts this season that they were the moneyline underdog.

Blue Jays vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (54.4%)

Blue Jays vs Astros Moneyline

• The moneyline numbers for Blue Jays vs. Astros reveal Toronto as the favorite (-156) and Houston as the underdog (+132) on the road.

Blue Jays vs Astros Spread

• The Astros are +1.5 on the run line against the Blue Jays. The Astros are -156 to cover, and the Blue Jays are +130.

Blue Jays vs Astros Over/Under

• A combined run total of 8.5 has been set for Blue Jays-Astros on Sept. 10, with the over at -115 and the under at -105.

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Blue Jays vs Astros Betting Trends

• The Blue Jays have been chosen as favorites in 67 games this year and have walked away with the win 39 times (58.2%) in those games.
• Toronto has a record of 20-7 when favored by -156 or more this year.
• The Blue Jays and their opponents have gone over the total this season in 79 of their 143 opportunities.
• The Blue Jays are 84-59-0 against the spread in their 143 games with a line set by sportsbooks this season.
• The Astros have compiled a 28-22 record in games they were listed as the moneyline underdog (winning 56% of those games).
• Houston has a record of 6-2 when playing as a moneyline underdog with odds of +132 or longer (75%).
• The Astros have combined with opponents to go over the total 65 times this season for a 65-75-4 record against the over/under.
• The Astros have collected a 71-73-0 record ATS this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto in OBP (.396) this season, fueled by 158 hits. He has a .304 batting average and a slugging percentage of .500.
• Among qualifying batters in MLB, he ranks fifth in batting average, third in on-base percentage, and 21st in slugging.
• Guerrero has recorded a base hit in eight straight games. During his last 10 outings he is batting .439 with three doubles, two home runs, four walks and seven RBIs.
• George Springer has 128 hits, which ranks first among Toronto batters this season. He's batting .300 with 50 extra-base hits. He's also slugging .550 with an on-base percentage of .393.
• Among qualifying batters, he ranks seventh in batting average, fourth in on-base percentage and sixth in slugging percentage.
• Springer has picked up at least one hit in two straight games. During his last five outings he is batting .200 with a double, two home runs, three walks and two RBIs.
• Ernie Clement has collected 133 base hits, an OBP of .312 and a slugging percentage of .398 this season.
• Clement has recorded at least one base hit in four straight games. During his last five outings he is batting .278 with three doubles, two walks and an RBI.
• Alejandro Kirk has 12 home runs, 65 RBI and a batting average of .291 this season.

Astros Player Leaders

• Jose Altuve has racked up a slugging percentage of .440, a team-best for the Astros. He's batting .263 with an on-base percentage of .327.
• Including all qualifying players, he ranks 60th in batting average, while his on-base percentage is 81st and he is 71st in slugging.
• Jeremy Pena's 138 hits and .361 OBP both lead his team. He has a batting average of .303 while slugging .469.
• Including all qualified hitters, his batting average places him sixth, his on-base percentage is 20th, and he is 41st in slugging.
• Yainer Diaz is hitting .254 with 21 doubles, a triple, 18 home runs and 20 walks.
• Carlos Correa is hitting .274 with 24 doubles, 12 home runs and 38 walks.

Blue Jays vs Astros Head to Head

• 9/9/2025: 4-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 4/23/2025: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/22/2025: 5-1 HOU (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/21/2025: 7-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/3/2024: 9-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/2/2024: 7-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/1/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/3/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/2/2024: 2-1 TOR (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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