Blue Jays vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 2:12 a.m.

On Wednesday in MLB, the Toronto Blue Jays are playing the Houston Astros.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Astros Game Info

• Toronto Blue Jays (83-61) vs. Houston Astros (78-67)
• Date: Wednesday, September 10, 2025
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and SCHN

Blue Jays vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-130) | HOU: (+110)
• Spread: TOR: -1.5 (+162) | HOU: +1.5 (-196)
• Total: 8.5 -- Over: (-128) | Under: (+104)

Blue Jays vs Astros Probable Starting Pitchers

Probable Pitchers: José Berrios (Blue Jays) - 9-5, 4.02 ERA vs Jason Alexander (Astros) - 4-1, 4.68 ERA

The Blue Jays will give the nod to Jose Berrios (9-5, 4.02 ERA), who is eyeing win No. 10 on the season, and the Astros will counter with Jason Alexander (4-1, 4.68 ERA). Berrios' team is 17-11-0 against the spread this season in his starts. Berrios' team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 9-6. When Alexander starts, the Astros have gone 6-3-0 against the spread. The Astros were named the moneyline underdog for four Alexander starts this season -- they won each time.

Blue Jays vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (60%)

Blue Jays vs Astros Moneyline

• The moneyline numbers for Blue Jays vs. Astros reveal Toronto as the favorite (-130) and Houston as the underdog (+110) on the road.

Blue Jays vs Astros Spread

• The Blue Jays are hosting the Astros and are favored by 1.5 runs on the spread. The Blue Jays are +162 to cover the runline, with the Astros being -196.

Blue Jays vs Astros Over/Under

• A total of 8.5 runs has been set for the Blue Jays-Astros game on Sept. 10, with the over available at -128 and the under at +104.

Bet on Toronto Blue Jays vs. Houston Astros on FanDuel today!

Blue Jays vs Astros Betting Trends

• The Blue Jays have been chosen as favorites in 67 games this year and have walked away with the win 39 times (58.2%) in those games.
• This season Toronto has come away with a win 33 times in 49 chances when named as a favorite of at least -130 on the moneyline.
• The Blue Jays and their opponents have hit the over in 79 of their 143 games with a total set by oddsmakers this season.
• The Blue Jays have an against the spread record of 84-59-0 in 143 games with a line this season.
• The Astros have put together a 28-22 record in games they were listed as the moneyline underdog (winning 56% of those games).
• When it has played as a moneyline underdog with odds of +110 or longer, Houston has gone 16-12 (57.1%).
• The Astros have played in 144 games with an over/under set, and have combined with their opponents to go over the total 65 times (65-75-4).
• The Astros have a 71-73-0 record ATS this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto with an OBP of .396 this season while batting .304 with 76 walks and 92 runs scored. He has a slugging percentage of .500.
• Among qualified hitters in baseball, his batting average ranks fifth, his on-base percentage ranks third, and he is 21st in slugging.
• Guerrero will look for his ninth straight game with a hit in this matchup. In his last 10 games he is hitting .439 with three doubles, two home runs, four walks and seven RBIs.
• George Springer leads Toronto with 128 hits. He is batting .300 this season and has 50 extra-base hits. He's also slugging .550 with an on-base percentage of .393.
• Among qualifying hitters, he is seventh in batting average, fourth in on-base percentage and sixth in slugging percentage.
• Springer heads into this game looking to extend his two-game hit streak. During his last five outings he is batting .200 with a double, two home runs, three walks and two RBIs.
• Ernie Clement has 133 hits this season and has a slash line of .275/.312/.398.
• Clement has recorded a hit in four straight games. In his last five games he is batting .278 with three doubles, two walks and an RBI.
• Alejandro Kirk has 12 home runs, 65 RBI and a batting average of .291 this season.

Astros Player Leaders

• Jose Altuve has a .440 slugging percentage, which paces the Astros. He's batting .263 with an on-base percentage of .327.
• Including all qualified hitters, he is 60th in batting average, while his on-base percentage ranks 81st and he is 71st in slugging.
• Jeremy Pena paces his team with 138 hits and a .361 on-base percentage. He has a batting average of .303 while slugging .469.
• Including all qualified hitters, he ranks sixth in batting average, 20th in on-base percentage and 41st in slugging percentage.
• Yainer Diaz is batting .254 with 21 doubles, a triple, 18 home runs and 20 walks.
• Carlos Correa has 24 doubles, 12 home runs and 38 walks while hitting .274.

Blue Jays vs Astros Head to Head

• 9/9/2025: 4-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 4/23/2025: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/22/2025: 5-1 HOU (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/21/2025: 7-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/3/2024: 9-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/2/2024: 7-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/1/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/3/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/2/2024: 2-1 TOR (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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