Phillies vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 6:12 p.m.

The Philadelphia Phillies versus the Miami Marlins is on the MLB schedule for Wednesday.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Phillies vs Marlins Game Info

• Philadelphia Phillies (92-65) vs. Miami Marlins (77-80)
• Date: Wednesday, September 24, 2025
• Time: 6:45 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and FDSFL

Phillies vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-164) | MIA: (+138)
• Spread: PHI: -1.5 (+128) | MIA: +1.5 (-154)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Phillies vs Marlins Probable Starting Pitchers

Probable Pitchers: Jesús Luzardo (Phillies) - 14-7, 4.08 ERA vs Ryan Weathers (Marlins) - 2-1, 3.21 ERA

The Phillies will give the ball to Jesus Luzardo (14-7, 4.08 ERA), who is eyeing win No. 15 on the season, and the Marlins will turn to Ryan Weathers (2-1, 3.21 ERA). Luzardo and his team are 14-16-0 ATS this season when he starts. Luzardo's team has been victorious in 62.5% of the games he's started as the moneyline favorite with a record of 15-9. The Marlins have a 4-2-0 record against the spread in Weathers' starts. The Marlins have been the underdog on the moneyline in five of Weathers' starts this season, and they went 2-3 in those games.

Phillies vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (68.2%)

Phillies vs Marlins Moneyline

• Looking at the moneyline for Phillies-Marlins, Philadelphia is the favorite at -164, and Miami is +138 playing on the road.

Phillies vs Marlins Spread

• The Marlins are at +1.5 on the runline against the Phillies. The Marlins are -154 to cover the spread, and the Phillies are +128.

Phillies vs Marlins Over/Under

• Phillies versus Marlins on Sept. 24 has an over/under of 7.5 runs, with the odds on the over -118 and the under set at -104.

Bet on Philadelphia Phillies vs. Miami Marlins on FanDuel today!

Phillies vs Marlins Betting Trends

• The Phillies have been favorites in 117 games this season and have come away with the win 75 times (64.1%) in those contests.
• This season Philadelphia has been victorious 38 times in 52 chances when named as a favorite of at least -164 on the moneyline.
• The Phillies and their opponents have hit the over in 64 of their 150 games with a total set by oddsmakers this season.
• The Phillies are 77-73-0 against the spread in their 150 games with a line set by sportsbooks this season.
• The Marlins have put together a 60-63 record in games they were the underdog on the moneyline (winning 48.8% of those games).
• Miami is 22-22 (winning 50% of its games) when playing as a moneyline underdog of +138 or longer.
• The Marlins have combined with opponents to hit the over on the total 76 times this season for a 76-75-1 record against the over/under.
• The Marlins have put together an 88-64-0 record ATS this season (covering 57.9% of the time).

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia with 141 hits and an OBP of .367 this season. He has a .241 batting average and a slugging percentage of .562.
• Among qualifying batters in baseball, he ranks 108th in batting average, 11th in on-base percentage, and fourth in slugging.
• Bryce Harper is batting .263 with 32 doubles, 27 home runs and 68 walks. He's slugging .495 with an on-base percentage of .358.
• Among qualifying hitters, his batting average ranks him 53rd, his on-base percentage 23rd, and his slugging percentage 18th.
• Bryson Stott is batting .255 with a .387 slugging percentage and 65 RBI this year.
• Nick Castellanos is batting .256 with a .299 OBP and 71 RBI for Philadelphia this season.
• Castellanos brings a four-game hitting streak into this game. In his last five games he is batting .357 with a home run, a walk and five RBIs.

Marlins Player Leaders

• Otto Lopez has 20 doubles, 15 home runs and 44 walks while hitting .250. He's slugging .373 with an on-base percentage of .310.
• Including all qualifying hitters, he ranks 91st in batting average, while his on-base percentage ranks 107th and he is 128th in slugging.
• Lopez enters this matchup on a five-game hitting streak. During his last five outings he is hitting .333 with two doubles, a home run and three RBIs.
• Agustin Ramirez leads his team with 121 hits. He has a batting average of .233 while slugging .422 with an on-base percentage of .291.
• He is 126th in batting average, 130th in on-base percentage and 78th in slugging percentage in the majors.
• Xavier Edwards has put up an on-base percentage of .337 and a slugging percentage of .352. Both lead the Marlins.
• Eric Wagaman is hitting .248 with 27 doubles, three triples, nine home runs and 32 walks.

Phillies vs Marlins Head to Head

• 9/23/2025: 6-5 MIA (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 9/7/2025: 5-4 MIA (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 4-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/5/2025: 9-3 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 6/19/2025: 2-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/18/2025: 4-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 6/16/2025: 5-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/20/2025: 7-5 MIA (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 4/19/2025: 11-10 PHI (Favorite: Phillies, Spread: -1.5, Total: 10.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 4/18/2025: 7-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -220, Underdog Moneyline: +184)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!