Pirates vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 1:12 a.m.

The Pittsburgh Pirates will face the Athletics in MLB action on Sunday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Pirates vs Athletics Game Info

• Pittsburgh Pirates (66-89) vs. Athletics (73-82)
• Date: Sunday, September 21, 2025
• Time: 1:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and NBCS-CA

Pirates vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-112) | OAK: (-104)
• Spread: PIT: +1.5 (-192) | OAK: -1.5 (+158)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Pirates vs Athletics Probable Starting Pitchers

Probable Pitchers: Mike Burrows (Pirates) - 2-4, 4.10 ERA vs Mitch Spence (Athletics) - 3-5, 4.48 ERA

This contest's pitching matchup is set, as the Pirates will send Mike Burrows (2-4) to the mound, while Mitch Spence (3-5) will get the nod for the Athletics. Burrows and his team have a record of 9-8-0 against the spread when he starts. When Burrows starts a game and his team is the favorite on the moneyline, they have a record of 1-3. When Spence starts, the Athletics are 4-3-0 against the spread. The Athletics are 2-5 in Spence's seven starts this season that they were the underdog on the moneyline.

Pirates vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51%)

Pirates vs Athletics Moneyline

• The Pirates vs Athletics moneyline has the Pirates as a -112 favorite, while the Athletics are a -104 underdog on the road.

Pirates vs Athletics Spread

• The Pirates are hosting the Athletics and are 1.5 on the runline and -192 to cover, while Sacramento is +158 to cover the spread.

Pirates vs Athletics Over/Under

• The Pirates-Athletics contest on Sept. 21 has been given an over/under of 8.5 runs. The over is set at -114 and the under at -106.

Bet on Pittsburgh Pirates vs. Athletics on FanDuel today!

Pirates vs Athletics Betting Trends

• The Pirates have won in 20, or 50%, of the 40 contests they have been named as odds-on favorites in this year.
• This season, the Pirates have come away with a win 20 times in 38 chances when named as a favorite of at least -112 or better on the moneyline.
• The Pirates and their opponents have hit the over in 56 of their 147 games with a total this season.
• The Pirates are 79-68-0 against the spread in their 147 games with a line set by sportsbooks this season.
• The Athletics have won 46.5% of the games this season they were the moneyline underdog (53-61).
• The Athletics have gone 50-59 in games they have played as a moneyline underdog with odds of -104 or longer (45.9%).
• The Athletics have played in 154 games with a set over/under, and have combined with their opponents to go over the total 74 times (74-73-7).
• The Athletics have put together an 82-72-0 record against the spread this season.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with 137 hits and a team-best slugging percentage of .403. He's batting .243 with an on-base percentage of .315.
• Among qualified hitters in the majors, his batting average ranks 103rd, his on-base percentage ranks 102nd, and he is 95th in slugging.
• Reynolds will look for his third straight game with a hit in this contest. In his last five games he is batting .222 with a double, a home run, three walks and two RBIs.
• Andrew McCutchen has 110 hits this season and a team-best OBP of .335. He's batting .240 and slugging .373.
• He is 110th in batting average, 59th in on-base percentage and 127th in slugging in MLB.
• Oneil Cruz has 92 hits this season and has a slash line of .203/.304/.381.
• Spencer Horwitz is batting .259 with a .338 OBP and 43 RBI for Pittsburgh this season.

Athletics Player Leaders

• Brent Rooker has a .488 slugging percentage, which leads the Athletics. He's batting .264 with an on-base percentage of .335.
• Including all the qualified hitters in the majors, he is 54th in batting average, 59th in on-base percentage and 25th in slugging percentage.
• Tyler Soderstrom is batting .276 with 31 doubles, a triple, 24 home runs and 53 walks. He's slugging .470 with an on-base percentage of .346.
• Including all qualifying hitters, his batting average places him 31st, his on-base percentage is 45th, and he is 42nd in slugging.
• Nick Kurtz is batting .291 with 25 doubles, two triples, 33 home runs and 60 walks.
• Jacob Wilson leads his team with a .359 on-base percentage.

Pirates vs Athletics Head to Head

• 9/20/2025: 2-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/19/2025: 4-3 OAK (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/1/2024: 4-0 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/30/2024: 5-2 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/29/2024: 5-1 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/7/2023: 9-5 OAK (Favorite: Pirates, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/6/2023: 11-2 OAK (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 6/5/2023: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -178, Underdog Moneyline: +150)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!