Pirates vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 1:12 p.m.

The MLB slate on Sunday includes the Pittsburgh Pirates taking on the Athletics.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Pirates vs Athletics Game Info

• Pittsburgh Pirates (66-89) vs. Athletics (73-82)
• Date: Sunday, September 21, 2025
• Time: 1:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and NBCS-CA

Pirates vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-118) | OAK: (-100)
• Spread: PIT: +1.5 (-210) | OAK: -1.5 (+172)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Pirates vs Athletics Probable Starting Pitchers

Probable Pitchers: Mike Burrows (Pirates) - 2-4, 4.10 ERA vs Mitch Spence (Athletics) - 3-5, 4.48 ERA

This contest's pitching matchup is set, as the Pirates will send Mike Burrows (2-4) to the mound, while Mitch Spence (3-5) will take the ball for the Athletics. Burrows and his team have a record of 9-8-0 against the spread when he starts. Burrows' team has a record of 1-3 this season when he starts and they are the favorite on the moneyline. The Athletics have gone 4-3-0 ATS in Spence's seven starts that had a set spread. The Athletics are 2-5 in Spence's seven starts this season that they were the underdog on the moneyline.

Pirates vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (53.6%)

Pirates vs Athletics Moneyline

• The Pirates vs Athletics moneyline has the Pirates as a -118 favorite, while the Athletics are a -100 underdog on the road.

Pirates vs Athletics Spread

• The Pirates are hosting the Athletics and are 1.5 on the runline and -210 to cover, while Sacramento is +172 to cover the spread.

Pirates vs Athletics Over/Under

• An over/under of 8.5 has been set for Pirates-Athletics on Sept. 21, with the over being -110 and the under -110.

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Pirates vs Athletics Betting Trends

• The Pirates have been victorious in 20, or 50%, of the 40 contests they have been chosen as favorites in this season.
• This year, the Pirates have won 15 of 33 games when listed as at least -118 or better on the moneyline.
• The Pirates and their opponents have hit the over in 56 of their 147 games with a total this season.
• In 147 games with a line this season, the Pirates have a mark of 79-68-0 against the spread.
• The Athletics have gone 53-61 in games they were the underdog on the moneyline (winning 46.5% of those games).
• The Athletics have gone 44-58 when playing as a moneyline underdog with odds of -100 or longer (43.1%).
• The Athletics have combined with their opponents to hit the over on the total 74 times this season for a 74-73-7 record against the over/under.
• The Athletics have covered 53.2% of their games this season, going 82-72-0 against the spread.

Pirates Player Leaders

• Bryan Reynolds has 137 hits to go with a slugging percentage of .403, both of which lead Pittsburgh hitters this season. He has a .243 batting average and an on-base percentage of .315.
• He is 103rd in batting average, 102nd in on-base percentage, and 96th in slugging among qualifying batters in the majors.
• Reynolds will look for his third straight game with a hit in this contest. In his last five games he is batting .222 with a double, a home run, three walks and two RBIs.
• Andrew McCutchen has 110 hits this season and a team-best OBP of .335. He's batting .240 and slugging .373.
• Among qualifying hitters, his batting average ranks him 110th, his on-base percentage 59th, and his slugging percentage 127th.
• Oneil Cruz has 92 hits this season and has a slash line of .203/.304/.381.
• Spencer Horwitz has nine home runs, 43 RBI and a batting average of .259 this season.

Athletics Player Leaders

• Brent Rooker has accumulated a slugging percentage of .488, a team-high for the Athletics. He's batting .264 with an on-base percentage of .335.
• Including all the qualified hitters in the big leagues, his batting average is 54th, his on-base percentage is 59th, and he is 25th in slugging.
• Tyler Soderstrom has 31 doubles, a triple, 24 home runs and 53 walks while hitting .276. He's slugging .470 with an on-base percentage of .346.
• Including all qualified hitters, his batting average places him 31st, his on-base percentage is 44th, and he is 42nd in slugging.
• Nick Kurtz has 25 doubles, two triples, 33 home runs and 60 walks while hitting .291.
• Jacob Wilson leads his team with a .359 OBP.

Pirates vs Athletics Head to Head

• 9/20/2025: 2-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/19/2025: 4-3 OAK (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/1/2024: 4-0 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/30/2024: 5-2 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/29/2024: 5-1 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/7/2023: 9-5 OAK (Favorite: Pirates, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/6/2023: 11-2 OAK (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 6/5/2023: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -178, Underdog Moneyline: +150)

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