Red Sox vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 7:11 p.m.

The Saturday slate in MLB includes a matchup between the Boston Red Sox and the Arizona Diamondbacks.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Diamondbacks Game Info

• Boston Red Sox (78-64) vs. Arizona Diamondbacks (71-71)
• Date: Saturday, September 6, 2025
• Time: 8:10 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NESN

Red Sox vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-112) | ARI: (-104)
• Spread: BOS: -1.5 (+140) | ARI: +1.5 (-170)
• Total: 9 -- Over: (-104) | Under: (-118)

Red Sox vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Lucas Giolito (Red Sox) - 10-2, 3.38 ERA vs Brandon Pfaadt (Diamondbacks) - 12-8, 5.33 ERA

The Red Sox will give the ball to Lucas Giolito (10-2, 3.38 ERA), who is eyeing win No. 11 on the season, and the Diamondbacks will counter with Brandon Pfaadt (12-8, 5.33 ERA). Giolito and his team have a record of 16-6-0 against the spread when he starts. When Giolito starts a game and his team is the favorite on the moneyline, they have a record of 9-2. When Pfaadt starts, the Diamondbacks are 17-11-0 against the spread. The Diamondbacks are 6-7 in Pfaadt's 13 starts this season that they were the underdog on the moneyline.

Red Sox vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (55%)

Red Sox vs Diamondbacks Moneyline

• Looking at the moneyline for Diamondbacks-Red Sox, Arizona is the underdog at -104, and Boston is -112 playing on the road.

Red Sox vs Diamondbacks Spread

• The Diamondbacks are at +1.5 on the runline against the Red Sox. The Diamondbacks are -170 to cover the spread, and the Red Sox are +140.

Red Sox vs Diamondbacks Over/Under

• A combined run total of 9 has been set for Red Sox-Diamondbacks on Sept. 6, with the over at -104 and the under at -118.

Bet on Boston Red Sox vs. Arizona Diamondbacks on FanDuel today!

Red Sox vs Diamondbacks Betting Trends

• The Red Sox have come away with 52 wins in the 89 contests they have been listed as the favorites in this season.
• Boston has a record of 51-34 when favored by -112 or more this year.
• Contests with the Red Sox have gone over the total set by bookmakers in 68 of 141 chances this season.
• In 141 games with a line this season, the Red Sox have a mark of 76-65-0 against the spread.
• The Diamondbacks have been the underdog on the moneyline 56 total times this season. They've gone 27-29 in those games.
• When playing as a moneyline underdog with odds of -104 or longer, Arizona has a 25-28 record (winning 47.2% of its games).
• In the 138 games bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 68 times (68-64-6).
• The Diamondbacks have a 68-70-0 record against the spread this season.

Red Sox Player Leaders

• Jarren Duran leads Boston in OBP (.336), slugging percentage (.446) and total hits (140) this season. He has a .258 batting average.
• Among all qualified hitters in the majors, he is 81st in batting average, 63rd in on-base percentage, and 68th in slugging.
• Trevor Story is hitting .259 with 24 doubles, 23 home runs and 30 walks. He's slugging .434 with an on-base percentage of .306.
• Among qualifying batters, he ranks 78th in batting average, 122nd in on-base percentage and 77th in slugging percentage.
• Ceddanne Rafaela is batting .246 with a .420 slugging percentage and 60 RBI this year.
• Alex Bregman has been key for Boston with 103 hits, an OBP of .366 plus a slugging percentage of .488.

Diamondbacks Player Leaders

• Geraldo Perdomo has put up a team-high .452 slugging percentage. He's batting .287 with an on-base percentage of .385.
• He ranks 18th in batting average, seventh in on-base percentage and 56th in slugging percentage among all qualifying hitters in MLB.
• Corbin Carroll's 129 hits pace his team. He has a batting average of .259 while slugging .559 with an on-base percentage of .334.
• His batting average is 78th among all qualified players, his on-base percentage is 66th, and he is fifth in slugging.
• Ketel Marte a has .390 on-base percentage to pace the Diamondbacks.
• Gabriel Moreno is batting .274 with 10 doubles, a triple, seven home runs and 17 walks.

Red Sox vs Diamondbacks Head to Head

• 9/5/2025: 10-5 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/25/2024: 7-5 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/24/2024: 4-1 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/23/2024: 12-2 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2023: 4-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/27/2023: 2-1 BOS (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/26/2023: 7-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!