Red Sox vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 7:14 a.m.

The Boston Red Sox are among the MLB squads busy on Saturday, versus the Arizona Diamondbacks.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Red Sox vs Diamondbacks Game Info

• Boston Red Sox (78-64) vs. Arizona Diamondbacks (71-71)
• Date: Saturday, September 6, 2025
• Time: 8:10 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NESN

Red Sox vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-112) | ARI: (-104)
• Spread: BOS: -1.5 (+150) | ARI: +1.5 (-182)
• Total: 8.5 -- Over: (-124) | Under: (+102)

Red Sox vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Lucas Giolito (Red Sox) - 10-2, 3.38 ERA vs Brandon Pfaadt (Diamondbacks) - 12-8, 5.33 ERA

This contest's pitching matchup is set, as the Red Sox will send Lucas Giolito (10-2) to the mound, while Brandon Pfaadt (12-8) will answer the bell for the Diamondbacks. Giolito and his team are 16-6-0 ATS this season when he starts. Giolito's team has been victorious in 81.8% of the games he's started as the moneyline favorite with a record of 9-2. The Diamondbacks have a 17-11-0 ATS record in Pfaadt's 28 starts that had a set spread. The Diamondbacks are 6-7 in Pfaadt's 13 starts this season that they were the underdog on the moneyline.

Red Sox vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (53.8%)

Red Sox vs Diamondbacks Moneyline

• The moneyline numbers for Red Sox vs. Diamondbacks reveal Boston as the favorite (-112) and Arizona as the underdog (-104) despite being the home team.

Red Sox vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the spread (-182 to cover), and Boston is +150 to cover the runline.

Red Sox vs Diamondbacks Over/Under

• Red Sox versus Diamondbacks, on Sept. 6, has an over/under of 8.5, with the over being -124 and the under +102.

Bet on Boston Red Sox vs. Arizona Diamondbacks on FanDuel today!

Red Sox vs Diamondbacks Betting Trends

• The Red Sox have won in 52, or 58.4%, of the 89 contests they have been named as odds-on favorites in this year.
• This season Boston has come away with a win 51 times in 85 chances when named as a favorite of at least -112 on the moneyline.
• The Red Sox and their opponents have gone over in 68 of their 141 games with a total set by sportsbooks this season.
• In 141 games with a line this season, the Red Sox have a mark of 76-65-0 against the spread.
• The Diamondbacks have won 48.2% of the games this season they were the underdog on the moneyline (27-29).
• In games it has played as a moneyline underdog with odds of -104 or longer, Arizona has gone 25-28 (47.2%).
• The Diamondbacks have combined with opponents to hit the over on the total 68 times this season for a 68-64-6 record against the over/under.
• The Diamondbacks have collected a 68-70-0 record against the spread this season.

Red Sox Player Leaders

• Jarren Duran leads Boston with 140 hits and an OBP of .336, plus a team-best slugging percentage of .446. He's batting .258.
• He ranks 81st in batting average, 63rd in on-base percentage, and 67th in slugging among all qualified hitters in baseball.
• Trevor Story is hitting .259 with 24 doubles, 23 home runs and 30 walks. He's slugging .434 with an on-base percentage of .306.
• Among all qualified, he ranks 78th in batting average, 122nd in on-base percentage and 77th in slugging percentage.
• Ceddanne Rafaela has 118 hits this season and has a slash line of .246/.290/.420.
• Alex Bregman has been key for Boston with 103 hits, an OBP of .366 plus a slugging percentage of .488.

Diamondbacks Player Leaders

• Geraldo Perdomo has put up a slugging percentage of .452, a team-best for the Diamondbacks. He's batting .287 with an on-base percentage of .385.
• Including all qualified hitters in the majors, he ranks 18th in batting average, seventh in on-base percentage and 56th in slugging percentage.
• Corbin Carroll has collected 129 hits to pace his team. He has a batting average of .259 while slugging .559 with an on-base percentage of .334.
• Including all qualifying hitters, his batting average places him 78th, his on-base percentage is 66th, and he is fifth in slugging.
• Ketel Marte has accumulated an on-base percentage of .390, a team-high for the Diamondbacks.
• Gabriel Moreno has 10 doubles, a triple, seven home runs and 17 walks while batting .274.

Red Sox vs Diamondbacks Head to Head

• 9/5/2025: 10-5 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/25/2024: 7-5 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/24/2024: 4-1 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/23/2024: 12-2 ARI (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2023: 4-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/27/2023: 2-1 BOS (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/26/2023: 7-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)

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