Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 8:11 p.m.

On Wednesday in MLB, the San Diego Padres are playing the Cincinnati Reds.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Reds Game Info

• San Diego Padres (79-66) vs. Cincinnati Reds (73-72)
• Date: Wednesday, September 10, 2025
• Time: 8:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSOH

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-148) | CIN: (+126)
• Spread: SD: -1.5 (+150) | CIN: +1.5 (-182)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 13-5, 2.85 ERA vs Andrew Abbott (Reds) - 8-6, 2.88 ERA

The Padres will give the nod to Nick Pivetta (13-5, 2.85 ERA), who is eyeing win No. 14 on the season, and the Reds will turn to Andrew Abbott (8-6, 2.88 ERA). Pivetta and his team have a record of 16-12-0 against the spread when he starts. Pivetta's team has a record of 11-7 this season when he starts and they are the favorite on the moneyline. The Reds have a 13-11-0 record against the spread in Abbott's starts. The Reds have been the underdog on the moneyline in nine of Abbott's starts this season, and they went 5-4 in those matchups.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.9%)

Padres vs Reds Moneyline

• San Diego is a -148 favorite on the moneyline, while Cincinnati is a +126 underdog on the road.

Padres vs Reds Spread

• The Reds are at the Padres, and are +1.5 on the runline. The Reds are +150 to cover the spread, and the Padres are -182.

Padres vs Reds Over/Under

• Padres versus Reds, on Sept. 10, has an over/under of 7.5, with the over being -110 and the under -110.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have been victorious in 46, or 59.7%, of the 77 contests they have been chosen as favorites in this season.
• San Diego has a record of 25-17 when favored by -148 or more this year.
• Contests with the Padres have gone over the total set by oddsmakers in 62 of 143 chances this season.
• The Padres are 77-66-0 against the spread in their 143 games with a line set by sportsbooks this season.
• The Reds are 37-41 in games they were the underdog on the moneyline (winning 47.4% of those games).
• Cincinnati is 15-15 (winning 50% of its games) when it has played as a moneyline underdog of +126 or longer.
• In the 138 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 54 times (54-76-8).
• The Reds have collected a 72-66-0 record against the spread this season (covering 52.2% of the time).

Padres Player Leaders

• Fernando Tatis Jr. is hitting .261 with 27 doubles, two triples, 20 home runs and 84 walks. He has an on-base percentage of .365 while slugging .429.
• Among qualifying hitters in baseball, he is 70th in batting average, 15th in on-base percentage, and 78th in slugging.
• Manny Machado has 33 doubles, 23 home runs and 51 walks. He's batting .276 and slugging .458 with an on-base percentage of .337.
• Among all qualified, he ranks 29th in batting average, 55th in on-base percentage and 50th in slugging percentage.
• Luis Arraez leads San Diego in slugging percentage (.386) powered by 40 extra-base hits.
• Ramon Laureano has 23 home runs, 71 RBI and a batting average of .295 this season.

Reds Player Leaders

• Elly De La Cruz has 152 hits with a .442 slugging percentage, both team-high numbers for the Reds. He's batting .267 and with an on-base percentage of .335.
• Including all qualifying hitters in the big leagues, his batting average places him 47th, his on-base percentage is 62nd, and he is 70th in slugging.
• De La Cruz hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .200 with a double, a walk and three RBIs.
• TJ Friedl's .363 OBP paces his team. He has a batting average of .264 while slugging .380.
• Including all qualified hitters, he ranks 59th in batting average, 19th in on-base percentage and 126th in slugging percentage.
• Spencer Steer is batting .237 with 20 doubles, two triples, 17 home runs and 45 walks.
• Austin Hays is batting .265 with 15 doubles, five triples, 15 home runs and 27 walks.

Padres vs Reds Head to Head

• 9/9/2025: 4-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/8/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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