Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 7:16 a.m.

The MLB's Wednesday schedule includes the San Diego Padres facing the Cincinnati Reds.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Reds Game Info

• San Diego Padres (79-66) vs. Cincinnati Reds (73-72)
• Date: Wednesday, September 10, 2025
• Time: 8:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSOH

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-168) | CIN: (+142)
• Spread: SD: -1.5 (+128) | CIN: +1.5 (-154)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 13-5, 2.85 ERA vs Andrew Abbott (Reds) - 8-6, 2.88 ERA

The Padres will give the nod to Nick Pivetta (13-5, 2.85 ERA), who is eyeing win No. 14 on the season, and the Reds will turn to Andrew Abbott (8-6, 2.88 ERA). When Pivetta starts, his team is 16-12-0 against the spread this season. Pivetta's team has been victorious in 61.1% of the games he's started as the moneyline favorite with a record of 11-7. The Reds have a 13-11-0 ATS record in Abbott's 24 starts that had a set spread. The Reds have a 5-4 record in Abbott's nine starts this season when they were the underdog on the moneyline.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.9%)

Padres vs Reds Moneyline

• San Diego is the favorite, -168 on the moneyline, while Cincinnati is a +142 underdog on the road.

Padres vs Reds Spread

• The Reds are at +1.5 on the runline against the Padres. The Reds are -154 to cover the spread, and the Padres are +128.

Padres vs Reds Over/Under

• Padres versus Reds on Sept. 10 has an over/under of 7.5 runs, with the odds on the over -112 and the under set at -108.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have won in 46, or 59.7%, of the 77 contests they have been named as odds-on favorites in this year.
• This season San Diego has come away with a win 16 times in 27 chances when named as a favorite of at least -168 on the moneyline.
• Contests with the Padres have gone over the total set by sportsbooks in 62 of 143 chances this season.
• In 143 games with a line this season, the Padres have a mark of 77-66-0 against the spread.
• The Reds have been the underdog on the moneyline 78 total times this season. They've finished 37-41 in those games.
• Cincinnati has a record of 6-11 when it has played as a moneyline underdog with odds of +142 or longer (35.3%).
• The Reds have had an over/under set by oddsmakers 138 times, and have combined with opponents to go over the total in 54 of those games (54-76-8).
• The Reds have gone 72-66-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .261 with 27 doubles, two triples, 20 home runs and 84 walks. He has an on-base percentage of .365 while slugging .429.
• Among all qualifying batters, he ranks 70th in batting average, his on-base percentage ranks 15th, and he is 78th in slugging.
• Manny Machado is hitting .276 with 33 doubles, 23 home runs and 51 walks. He's slugging .458 with an on-base percentage of .337.
• Among all qualified batters, he ranks 29th in batting average, 54th in on-base percentage and 50th in slugging percentage.
• Luis Arraez leads San Diego in slugging percentage (.386) powered by 40 extra-base hits.
• Ramon Laureano has 23 home runs, 71 RBI and a batting average of .295 this season.

Reds Player Leaders

• Elly De La Cruz has racked up 152 hits with a .442 slugging percentage, both team-best numbers for the Reds. He's batting .267 and with an on-base percentage of .335.
• He ranks 48th in batting average, 60th in on-base percentage and 68th in slugging percentage among all qualified hitters in the big leagues.
• De La Cruz hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .200 with a double, a walk and three RBIs.
• TJ Friedl has a .363 on-base percentage to pace his team. He has a batting average of .264 while slugging .380.
• Including all qualified hitters, his batting average places him 57th, his on-base percentage ranks 19th, and he is 126th in slugging.
• Spencer Steer has 20 doubles, two triples, 17 home runs and 45 walks while batting .237.
• Austin Hays is batting .265 with 15 doubles, five triples, 15 home runs and 27 walks.

Padres vs Reds Head to Head

• 9/9/2025: 4-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/8/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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