Mariners vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 7:16 a.m.

The Seattle Mariners are among the MLB teams in action on Wednesday, up against the St. Louis Cardinals.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Cardinals Game Info

• Seattle Mariners (77-68) vs. St. Louis Cardinals (72-74)
• Date: Wednesday, September 10, 2025
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ROOT Sports NW and FDSMW

Mariners vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-225) | STL: (+188)
• Spread: SEA: -1.5 (-104) | STL: +1.5 (-115)
• Total: 7.5 -- Over: (-102) | Under: (-120)

Mariners vs Cardinals Probable Starting Pitchers

Probable Pitchers: Logan Gilbert (Mariners) - 4-6, 3.61 ERA vs Michael McGreevy (Cardinals) - 6-3, 4.68 ERA

The Mariners will give the ball to Logan Gilbert (4-6, 3.61 ERA), who is eyeing win No. 5 on the season, and the Cardinals will turn to Michael McGreevy (6-3, 4.68 ERA). Gilbert's team is 6-14-0 against the spread this season in his starts. Gilbert's team has been victorious in 68.8% of the games he's started as the moneyline favorite with a record of 11-5. The Cardinals have a 7-5-0 ATS record in McGreevy's 12 starts with a set spread. The Cardinals have a 5-1 record in McGreevy's six starts this season when they were the underdog on the moneyline.

Mariners vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (64.9%)

Mariners vs Cardinals Moneyline

• Seattle is the favorite, -225 on the moneyline, while St. Louis is a +188 underdog on the road.

Mariners vs Cardinals Spread

• The Mariners are 1.5-run home favorites on the runline against the Cardinals. The Mariners are -104 to cover, and the Cardinals are -115.

Mariners vs Cardinals Over/Under

• Mariners versus Cardinals, on Sept. 10, has an over/under of 7.5, with the over being -102 and the under -120.

Bet on Seattle Mariners vs. St. Louis Cardinals on FanDuel today!

Mariners vs Cardinals Betting Trends

• The Mariners have been chosen as favorites in 98 games this year and have walked away with the win 55 times (56.1%) in those games.
• Seattle has a record of 4-1 when favored by -225 or more this year.
• The Mariners' games have gone over the total in 75 of their 140 opportunities.
• The Mariners are 60-80-0 against the spread in their 140 games that had a posted line this season.
• The Cardinals have won 48.7% of the games this season they were the moneyline underdog (37-39).
• St. Louis has played as a moneyline underdog of +188 or longer in only one game this season, which it lost.
• The Cardinals have had an over/under set by bookmakers 140 times, and have combined with opponents to go over the total in 72 of those games (72-63-5).
• The Cardinals have a 70-70-0 record ATS this season (covering 50% of the time).

Mariners Player Leaders

• Cal Raleigh leads Seattle with 128 hits, batting .240 this season with 72 extra-base hits. He has an on-base percentage of .349 and a slugging percentage of .574.
• Among qualifying batters, he is 113th in batting average, his on-base percentage ranks 39th, and he is third in slugging.
• Julio Rodriguez leads Seattle in slugging percentage (.476) thanks to 60 extra-base hits. He's batting .266 with an on-base percentage of .317.
• He is 51st in batting average, 100th in on-base percentage and 33rd in slugging in the major leagues.
• Josh Naylor has collected 140 base hits, an OBP of .348 and a slugging percentage of .458 this season.
• Naylor heads into this game with four games in a row with at least one hit. During his last five outings he is batting .467 with a double, three home runs, a walk and seven RBIs.
• Eugenio Suarez has been key for Seattle with 122 hits, an OBP of .307 plus a slugging percentage of .543.

Cardinals Player Leaders

• Alec Burleson has racked up a team-best slugging percentage (.457) and leads the Cardinals in hits (125). He's batting .285 and with an on-base percentage of .335.
• Including all qualifying hitters in the majors, he ranks 19th in batting average, 60th in on-base percentage and 54th in slugging percentage.
• Willson Contreras is hitting .256 with 30 doubles, a triple, 20 home runs and 42 walks. He's slugging .449 with an on-base percentage of .339.
• Including all qualified players, his batting average puts him 81st, his on-base percentage ranks 52nd, and he is 62nd in slugging.
• Masyn Winn is hitting .253 with 27 doubles, nine home runs and 34 walks.
• Lars Nootbaar has 22 doubles, a triple, 13 home runs and 56 walks while hitting .241.

Mariners vs Cardinals Head to Head

• 9/9/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/8/2025: 4-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 9/8/2024: 10-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/7/2024: 2-0 STL (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/6/2024: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/23/2023: 7-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/22/2023: 5-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/21/2023: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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