Mariners vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 9:11 p.m.

MLB action on Wednesday includes the Seattle Mariners taking on the St. Louis Cardinals.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Mariners vs Cardinals Game Info

• Seattle Mariners (77-68) vs. St. Louis Cardinals (72-74)
• Date: Wednesday, September 10, 2025
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ROOT Sports NW and FDSMW

Mariners vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-220) | STL: (+184)
• Spread: SEA: -1.5 (-102) | STL: +1.5 (-118)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Mariners vs Cardinals Probable Starting Pitchers

Probable Pitchers: Logan Gilbert (Mariners) - 4-6, 3.61 ERA vs Michael McGreevy (Cardinals) - 6-3, 4.68 ERA

The Mariners will give the ball to Logan Gilbert (4-6, 3.61 ERA), who is eyeing win No. 5 on the season, and the Cardinals will turn to Michael McGreevy (6-3, 4.68 ERA). When Gilbert starts, his team is 6-14-0 against the spread this season. Gilbert's team has won 68.8% of his starts when they are favored on the moneyline (11-5). The Cardinals are 7-5-0 against the spread when McGreevy starts. The Cardinals have been the underdog on the moneyline in six of McGreevy's starts this season, and they went 5-1 in those matchups.

Mariners vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (65%)

Mariners vs Cardinals Moneyline

• The moneyline numbers for Mariners vs. Cardinals reveal Seattle as the favorite (-220) and St. Louis as the underdog (+184) on the road.

Mariners vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Mariners. The Cardinals are -118 to cover, and the Mariners are -102.

Mariners vs Cardinals Over/Under

• A combined run total of 7.5 has been set for Mariners-Cardinals on Sept. 10, with the over at -105 and the under at -115.

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Mariners vs Cardinals Betting Trends

• The Mariners have come away with 55 wins in the 98 contests they have been listed as the favorites in this season.
• Seattle has a record of 5-1 in contests when sportsbooks favor them by -220 or more on the moneyline.
• The Mariners and their opponents have hit the over in 75 of their 140 games with a total set by oddsmakers this season.
• In 140 games with a line this season, the Mariners have a mark of 60-80-0 against the spread.
• The Cardinals have won 48.7% of the games this season they were the moneyline underdog (37-39).
• St. Louis has played as a moneyline underdog of +184 or longer in only one game this season, which it lost.
• The Cardinals have had an over/under set by oddsmakers 140 times, and have combined with opponents to go over the total in 72 of those games (72-63-5).
• The Cardinals have covered 50% of their games this season, going 70-70-0 ATS.

Mariners Player Leaders

• Cal Raleigh leads Seattle in total hits (128) this season while batting .240 with 72 extra-base hits. He has an on-base percentage of .349 and a slugging percentage of .574.
• He ranks 113th in batting average, 38th in on-base percentage, and third in slugging among all qualified hitters in the majors.
• Julio Rodriguez leads Seattle in slugging percentage (.476) thanks to 60 extra-base hits. He's batting .266 with an on-base percentage of .317.
• He ranks 52nd in batting average, 99th in on-base percentage and 33rd in slugging in the majors.
• Josh Naylor has 140 hits this season and has a slash line of .286/.348/.458.
• Naylor has logged a hit or more in four straight games. During his last five outings he is hitting .467 with a double, three home runs, a walk and seven RBIs.
• Eugenio Suarez has been key for Seattle with 122 hits, an OBP of .307 plus a slugging percentage of .543.

Cardinals Player Leaders

• Alec Burleson has racked up 125 hits with a .457 slugging percentage, both team-high marks for the Cardinals. He's batting .285 and with an on-base percentage of .335.
• Including all qualified players, he ranks 19th in batting average, while his on-base percentage ranks 62nd and he is 54th in slugging.
• Willson Contreras has 30 doubles, a triple, 20 home runs and 42 walks while hitting .256. He's slugging .449 with an on-base percentage of .339.
• His batting average is 81st among all qualified players, his on-base percentage ranks 52nd, and he is 62nd in slugging.
• Masyn Winn has 27 doubles, nine home runs and 34 walks while batting .253.
• Lars Nootbaar is hitting .241 with 22 doubles, a triple, 13 home runs and 56 walks.

Mariners vs Cardinals Head to Head

• 9/9/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/8/2025: 4-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 9/8/2024: 10-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/7/2024: 2-0 STL (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/6/2024: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/23/2023: 7-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/22/2023: 5-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/21/2023: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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