Padres vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 4:14 a.m.

The Wednesday slate in MLB includes a matchup between the San Diego Padres and the Washington Nationals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Nationals Game Info

• San Diego Padres (43-36) vs. Washington Nationals (33-47)
• Date: Wednesday, June 25, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MASN2

Padres vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-146) | WSH: (+124)
• Spread: SD: -1.5 (+158) | WSH: +1.5 (-192)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Padres vs Nationals Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 7-2, 3.64 ERA vs MacKenzie Gore (Nationals) - 3-7, 3.19 ERA

The probable pitchers are Nick Pivetta (7-2) for the Padres and MacKenzie Gore (3-7) for the Nationals. When Pivetta starts, his team is 9-6-0 against the spread this season. Pivetta's team has won 42.9% of his starts when they are favored on the moneyline (3-4). The Nationals have an 8-8-0 ATS record in Gore's 16 starts that had a set spread. The Nationals are 4-4 in Gore's eight starts this season that they were the moneyline underdog.

Padres vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.3%)

Padres vs Nationals Moneyline

• San Diego is the favorite, -146 on the moneyline, while Washington is a +124 underdog on the road.

Padres vs Nationals Spread

• The Padres are favored by 1.5 runs at home against the Nationals. The Padres are +158 to cover the spread, while the Nationals are -192.

Padres vs Nationals Over/Under

• The over/under for Padres-Nationals on June 25 is 7.5. The over is -118, and the under is -104.

Bet on San Diego Padres vs. Washington Nationals on FanDuel today!

Padres vs Nationals Betting Trends

• The Padres have been victorious in 24, or 61.5%, of the 39 contests they have been chosen as favorites in this season.
• San Diego has a record of 17-8 in contests when oddsmakers favor them by -146 or more on the moneyline.
• The Padres and their opponents have gone over the total this season in 33 of their 78 opportunities.
• The Padres have posted a record of 42-36-0 against the spread this season.
• The Nationals have won 49.2% of the games this season they were the moneyline underdog (29-30).
• In games it has played as a moneyline underdog with odds of +124 or longer, Washington has an 18-22 record (winning 45% of its games).
• The Nationals have played in 76 games with an over/under set, and have combined with their opponents to go over the total 38 times (38-37-1).
• The Nationals have a 40-36-0 record against the spread this season (covering 52.6% of the time).

Padres Player Leaders

• Manny Machado has 91 hits and an OBP of .364 to go with a slugging percentage of .498. All three of those stats lead San Diego hitters this season. He has a .302 batting average, as well.
• He is 17th in batting average, 29th in on-base percentage, and 22nd in slugging among all qualified hitters in baseball.
• Machado hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .200 with a double, two home runs, two walks and two RBIs.
• Fernando Tatis Jr. has 11 doubles, a triple, 15 home runs and 37 walks. He's batting .264 and slugging .459 with an on-base percentage of .352.
• He is 66th in batting average, 48th in on-base percentage and 53rd in slugging among qualifying hitters.
• Luis Arraez is batting .282 with a .393 slugging percentage and 29 RBI this year.
• Arraez heads into this game with 11 games in a row with at least one hit. In his last 10 outings he is hitting .318 with a double, a triple and four RBIs.
• Gavin Sheets is batting .267 with a .326 OBP and 46 RBI for San Diego this season.
• Sheets brings a two-game hitting streak into this matchup. In his last five games he is batting .263 with two doubles, two walks and three RBIs.

Nationals Player Leaders

• James Wood has racked up 85 hits with a .377 on-base percentage and a .561 slugging percentage, all club-bests for the Nationals. He's batting .281.
• Including all the qualified players in MLB, his batting average is 39th, his on-base percentage is 19th, and he is seventh in slugging.
• C.J. Abrams is batting .287 with 17 doubles, two triples, 11 home runs and 21 walks. He's slugging .491 with an on-base percentage of .360.
• Including all qualifying hitters, his batting average places him 29th, his on-base percentage is 33rd, and he is 30th in slugging.
• Luis Garcia is hitting .271 with 19 doubles, seven home runs and 16 walks.
• Nathaniel Lowe has 12 doubles, 13 home runs and 28 walks while hitting .228.

Padres vs Nationals Head to Head

• 6/24/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/23/2025: 10-6 WSH (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/25/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/24/2024: 12-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/23/2024: 4-0 SD (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/26/2024: 8-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/25/2024: 9-7 SD (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/24/2024: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/25/2023: 8-3 WSH (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 6/24/2023: 2-0 WSH (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)

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