Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 3:12 p.m.

Sunday's slate in the MLB includes a matchup between the San Diego Padres and the Arizona Diamondbacks.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Padres vs Diamondbacks Game Info

• San Diego Padres (89-72) vs. Arizona Diamondbacks (80-81)
• Date: Sunday, September 28, 2025
• Time: 3:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and ARID

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-154) | ARI: (+130)
• Spread: SD: -1.5 (+138) | ARI: +1.5 (-166)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: JP Sears (Padres) - 0-0, 0.00 ERA vs Brandon Pfaadt (Diamondbacks) - 13-8, 5.00 ERA

The Padres will look to JP Sears against the Diamondbacks and Brandon Pfaadt (13-8). Sears did not appear in a game when his team was the moneyline favorite last season. When Pfaadt starts, the Diamondbacks are 20-12-0 against the spread. The Diamondbacks have been the moneyline underdog in 16 of Pfaadt's starts this season, and they went 8-8 in those matchups.

Padres vs Diamondbacks Moneyline

• Arizona is a +130 underdog on the moneyline, while San Diego is a -154 favorite at home.

Padres vs Diamondbacks Spread

• The Diamondbacks are at the Padres, and are +1.5 on the runline. The Diamondbacks are +138 to cover the spread, and the Padres are -166.

Padres vs Diamondbacks Over/Under

• A combined run total of 7.5 has been set for Padres-Diamondbacks on Sept. 28, with the over at -104 and the under at -118.

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Padres vs Diamondbacks Betting Trends

• The Padres have been favorites in 88 games this season and have come away with the win 53 times (60.2%) in those contests.
• San Diego has a record of 27-18 in contests when bookmakers favor them by -154 or more on the moneyline.
• Contests with the Padres have gone over the total set by bookmakers in 69 of 159 chances this season.
• The Padres have an against the spread mark of 86-73-0 in 159 games with a line this season.
• The Diamondbacks have put together a 33-36 record in games they were the underdog on the moneyline (winning 47.8% of those games).
• Arizona has a 9-8 record (winning 52.9% of its games) when it has played as a moneyline underdog of +130 or longer.
• The Diamondbacks have had an over/under set by bookmakers 157 times, and have combined with opponents to go over the total in 78 of those games (78-71-8).
• The Diamondbacks are 78-79-0 against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .267 with 27 doubles, two triples, 25 home runs and 89 walks. He has an on-base percentage of .367 and a slugging percentage of .446.
• Among qualifying hitters in the majors, his batting average ranks 44th, his on-base percentage ranks 11th, and he is 59th in slugging.
• Tatis will look for his eighth straight game with a hit in this contest. In his last 10 outings he is batting .385 with four home runs, five walks and eight RBIs.
• Manny Machado has 167 hits, which ranks first among San Diego batters this season. He's batting .272 with 59 extra-base hits. He's also slugging .454 with an on-base percentage of .333.
• Among all qualified, he is 36th in batting average, 63rd in on-base percentage and 53rd in slugging percentage.
• Luis Arraez leads San Diego in slugging percentage (.392) powered by 42 extra-base hits.
• Arraez enters this game with 15 games in a row with at least one hit. During his last 10 games he is batting .385 with a double, a home run, four walks and six RBIs.
• Ryan O'Hearn has been key for San Diego with 131 hits, an OBP of .365 plus a slugging percentage of .437.
• O'Hearn brings an eight-game hitting streak into this game. During his last 10 games he is hitting .400 with two doubles, a home run, three walks and nine RBIs.

Diamondbacks Player Leaders

• Geraldo Perdomo has accumulated an on-base percentage of .390 and a slugging percentage of .465. Both lead the Diamondbacks. He's batting .291.
• Including all qualifying hitters in the majors, his batting average places him 14th, his on-base percentage is fourth, and he is 44th in slugging.
• Perdomo brings a three-game hitting streak into this game. In his last five games he is batting .300 with two doubles, a home run, two walks and two RBIs.
• Corbin Carroll paces his team with 146 hits. He has a batting average of .259 while slugging .541 with an on-base percentage of .343.
• Including all qualified players, his batting average places him 70th, his on-base percentage ranks 50th, and he is seventh in slugging.
• Ketel Marte is hitting .283 with 28 doubles, 27 home runs and 64 walks.
• Gabriel Moreno is hitting .286 with 12 doubles, a triple, nine home runs and 28 walks.

Padres vs Diamondbacks Head to Head

• 9/27/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/26/2025: 7-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/6/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 10-5 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2025: 6-3 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/15/2025: 8-2 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)

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