Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 11:12 p.m.

The San Diego Padres will face the Arizona Diamondbacks in MLB action on Sunday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Diamondbacks Game Info

• San Diego Padres (88-72) vs. Arizona Diamondbacks (80-80)
• Date: Sunday, September 28, 2025
• Time: 3:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and ARID

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-154) | ARI: (+130)
• Spread: SD: -1.5 (+138) | ARI: +1.5 (-166)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: TBA (Padres) vs Brandon Pfaadt (Diamondbacks) - 13-8, 0.00 ERA

Pfaadt (13-8) will get the nod for the Diamondbacks. As of this writing, there's been no pitching decision announced by the Padres. The Diamondbacks have gone 20-12-0 against the spread when Pfaadt starts. The Diamondbacks have an 8-8 record in Pfaadt's 16 starts this season when they were the underdog on the moneyline.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (51%)

Padres vs Diamondbacks Moneyline

• San Diego is a -154 favorite on the moneyline, while Arizona is a +130 underdog on the road.

Padres vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the run line against the Padres. The Diamondbacks are -166 to cover, and the Padres are +138.

Padres vs Diamondbacks Over/Under

• Padres versus Diamondbacks on Sept. 28 has an over/under of 7.5 runs, with the odds on the over -104 and the under set at -118.

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Padres vs Diamondbacks Betting Trends

• The Padres have been chosen as favorites in 87 games this year and have walked away with the win 52 times (59.8%) in those games.
• This season San Diego has been victorious 26 times in 44 chances when named as a favorite of at least -154 on the moneyline.
• The Padres' games have gone over the total in 69 of their 158 opportunities.
• In 158 games with a line this season, the Padres have a mark of 85-73-0 against the spread.
• The Diamondbacks have gone 33-35 in games they were listed as the moneyline underdog (winning 48.5% of those games).
• Arizona is 9-8 (winning 52.9% of its games) when it has played as a moneyline underdog of +130 or longer.
• The Diamondbacks have had an over/under set by oddsmakers 156 times, and have combined with opponents to go over the total in 78 of those games (78-70-8).
• The Diamondbacks have a 78-78-0 record ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 24 home runs and 88 walks while hitting .266. He has an on-base percentage of .366 and a slugging percentage of .441.
• Among all qualifying hitters in MLB, he is 46th in batting average, 12th in on-base percentage, and 64th in slugging.
• Tatis has picked up at least one hit in six straight games. During his last 10 outings he is hitting .341 with three home runs, four walks and seven RBIs.
• Manny Machado leads San Diego in total hits (167) this season while batting .272 with 59 extra-base hits. He's slugging .454 with an on-base percentage of .333.
• He is 37th in batting average, 63rd in on-base percentage and 54th in slugging among qualifying hitters.
• Luis Arraez has an OPS of .721, fueled by an OBP of .328 and a team-best slugging percentage of .393 this season.
• Arraez has picked up a hit in 14 straight games. In his last 10 games he is batting .385 with a double, a home run, four walks and six RBIs.
• Ryan O'Hearn is batting .279 with a .366 OBP and 63 RBI for San Diego this season.
• O'Hearn takes a seven-game hitting streak into this matchup. In his last 10 outings he is batting .361 with a double, a home run, four walks and nine RBIs.

Diamondbacks Player Leaders

• Geraldo Perdomo has put up a .391 on-base percentage and a .461 slugging percentage, both team-high numbers for the Diamondbacks. He's batting .291.
• Including all qualified hitters, he ranks 14th in batting average, while his on-base percentage ranks fourth and he is 47th in slugging.
• Corbin Carroll leads his team with 146 hits. He has a batting average of .259 while slugging .541 with an on-base percentage of .343.
• He is currently 71st in batting average, 51st in on-base percentage and seventh in slugging percentage among all qualifying hitters.
• Ketel Marte is batting .283 with 28 doubles, 27 home runs and 64 walks.
• Gabriel Moreno is batting .282 with 12 doubles, a triple, nine home runs and 27 walks.

Padres vs Diamondbacks Head to Head

• 9/26/2025: 7-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/6/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 10-5 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2025: 6-3 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/15/2025: 8-2 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/14/2025: 8-7 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)

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