Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 2:15 p.m.

In MLB action on Sunday, the Houston Astros play the Los Angeles Angels.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Angels Game Info

• Houston Astros (86-75) vs. Los Angeles Angels (72-89)
• Date: Sunday, September 28, 2025
• Time: 3:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-144) | LAA: (+122)
• Spread: HOU: -1.5 (+114) | LAA: +1.5 (-137)
• Total: 9 -- Over: (-105) | Under: (-115)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Lance McCullers (Astros) - 2-5, 6.88 ERA vs Samuel Aldegheri (Angels) - 0-1, 8.00 ERA

This contest's pitching matchup is set, as the Astros will send Lance McCullers (2-5) to the mound, while Samuel Aldegheri (0-1) will take the ball for the Angels. McCullers' team is 7-5-0 against the spread this season in his starts. McCullers' team is 2-5 this season when he starts and they are the moneyline favorite. Aldegheri has started just one game with a set spread, which the Angels failed to cover. The Angels were named the moneyline underdog for one Aldegheri start this season -- they lost.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (58.1%)

Astros vs Angels Moneyline

• The Astros vs Angels moneyline has Houston as a -144 favorite, while Los Angeles is a +122 underdog at home.

Astros vs Angels Spread

• The Astros are at the Angels and are favored by 1.5 runs on the spread. The Astros are +114 to cover the runline, with the Angels being -137.

Astros vs Angels Over/Under

• The over/under for Astros-Angels on Sept. 28 is 9. The over is -105, and the under is -115.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have come away with 52 wins in the 98 contests they have been listed as the favorites in this season.
• Houston has a record of 22-16 in contests when bookmakers favor them by -144 or more on the moneyline.
• The Astros and their opponents have hit the over in 72 of their 160 games with a total set by oddsmakers this season.
• In 160 games with a line this season, the Astros have a mark of 79-81-0 against the spread.
• The Angels have won 43.3% of the games this season they were the underdog on the moneyline (52-68).
• Los Angeles has a record of 31-40 when playing as a moneyline underdog with odds of +122 or longer (43.7%).
• The Angels have had an over/under set by oddsmakers 159 times, and have combined with opponents to go over the total in 84 of those games (84-70-5).
• The Angels have put together an 83-76-0 record ATS this season (covering 52.2% of the time).

Astros Player Leaders

• Jose Altuve leads Houston with a slugging percentage of .442, fueled by 51 extra-base hits. He has a .265 batting average and an on-base percentage of .329.
• Among qualified hitters in the majors, his batting average ranks 47th, his on-base percentage ranks 74th, and he is 63rd in slugging.
• Jeremy Pena has 150 hits and an OBP of .363, both of which lead the Astros this season. He's batting .304 and slugging .477.
• Among all qualifying hitters, he ranks fifth in batting average, 17th in on-base percentage and 31st in slugging percentage.
• Christian Walker has collected 139 base hits, an OBP of .297 and a slugging percentage of .421 this season.
• Walker has picked up a hit in six games in a row. During his last 10 outings he is hitting .243 with a double, four home runs and seven RBIs.
• Yainer Diaz is batting .255 with a .283 OBP and 68 RBI for Houston this season.
• Diaz heads into this matchup on a two-game hitting streak. In his last five games he is hitting .235 with two doubles.

Angels Player Leaders

• Taylor Ward has accumulated a slugging percentage of .476, a team-high for the Angels. He's batting .228 with an on-base percentage of .317.
• Including all the qualifying hitters in MLB, his batting average is 139th, his on-base percentage is 98th, and he is 34th in slugging.
• Jo Adell leads his team with 123 hits. He has a batting average of .236 while slugging .487 with an on-base percentage of .293.
• His batting average ranks 123rd among all qualified players, his on-base percentage ranks 130th, and he is 22nd in slugging.
• Nolan Schanuel is batting .264 with 23 doubles, a triple, 12 home runs and 59 walks.
• Mike Trout's .357 on-base percentage paces his team.

Astros vs Angels Head to Head

• 9/27/2025: 6-1 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/26/2025: 4-3 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/1/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/31/2025: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/30/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/22/2025: 8-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!