Giants vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 7:13 a.m.

In MLB action on Friday, the San Francisco Giants face the Colorado Rockies.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Rockies Game Info

• San Francisco Giants (78-81) vs. Colorado Rockies (43-116)
• Date: Friday, September 26, 2025
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and COLR

Giants vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-240) | COL: (+198)
• Spread: SF: -1.5 (-110) | COL: +1.5 (-110)
• Total: 8 -- Over: (-115) | Under: (-105)

Giants vs Rockies Probable Starting Pitchers

Probable Pitchers: Trevor McDonald (Giants) - 0-0, 3.38 ERA vs German Marquez (Rockies) - 3-15, 6.49 ERA

The Giants will look to Trevor McDonald versus the Rockies and German Marquez (3-15). McDonald helped his team cover the spread in his only opportunity this season as a starter. McDonald has yet to start a game this season when his team was the moneyline favorite. The Rockies have a 7-17-0 ATS record in Marquez's 24 starts that had a set spread. The Rockies have been the underdog on the moneyline in 22 of Marquez's starts this season, and they went 5-17 in those matchups.

Giants vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (62.5%)

Giants vs Rockies Moneyline

• Looking at the moneyline for Giants-Rockies, San Francisco is the favorite at -240, and Colorado is +198 playing on the road.

Giants vs Rockies Spread

• The Giants are favored by 1.5 runs at home against the Rockies. The Giants are -110 to cover the spread, while the Rockies are -110.

Giants vs Rockies Over/Under

• An over/under of 8 has been set for Giants-Rockies on Sept. 26, with the over being -115 and the under -105.

Bet on San Francisco Giants vs. Colorado Rockies on FanDuel today!

Giants vs Rockies Betting Trends

• The Giants have come away with 47 wins in the 91 contests they have been listed as the favorites in this season.
• This year San Francisco has won three of four games when listed as at least -240 on the moneyline.
• Contests with the Giants have gone over the total set by sportsbooks in 76 of 158 chances this season.
• The Giants are 74-84-0 against the spread in their 158 games that had a posted line this season.
• The Rockies have a 38-111 record in games they were listed as the moneyline underdog (winning 25.5% of those games).
• When it has played as a moneyline underdog with odds of +198 or longer, Colorado has a 13-55 record (winning just 19.1% of its games).
• In the 154 games oddsmakers have set an over/under for the Rockies, they have combined with opponents to go over the total 68 times (68-81-5).
• The Rockies have covered 40.3% of their games this season, going 62-92-0 ATS.

Giants Player Leaders

• Rafael Devers leads San Francisco with 150 hits and an OBP of .370 this season. He has a .251 batting average and a slugging percentage of .474.
• Among the qualifying batters in MLB, his batting average ranks 89th, his on-base percentage ranks ninth, and he is 37th in slugging.
• Devers has hit safely in five straight games. During his last five outings he is batting .250 with three home runs, three walks and three RBIs.
• Jung Hoo Lee has 31 doubles, 11 triples, eight home runs and 47 walks. He's batting .260 and slugging .401 with an on-base percentage of .323.
• Among qualifying hitters, his batting average ranks him 66th, his on-base percentage 88th, and his slugging percentage 102nd.
• Lee heads into this game looking to extend his two-game hit streak. In his last five games he is batting .211 with a double, a walk and an RBI.
• Willy Adames is batting .225 with a .415 slugging percentage and 84 RBI this year.
• Adames has recorded at least one base hit in two games in a row. In his last five games he is hitting .200 with a double, three walks and two RBIs.
• Heliot Ramos leads San Francisco with a slugging percentage of .400, fueled by 45 extra-base hits.
• Ramos brings a three-game hitting streak into this game. In his last five games he is hitting .292 with two home runs and four RBIs.

Rockies Player Leaders

• Hunter Goodman has put up a team-best OBP (.323) and slugging percentage (.518), and paces the Rockies in hits (147, while batting .278).
• Including all the qualified players in MLB, he ranks 27th in batting average, 88th in on-base percentage and 13th in slugging percentage.
• Mickey Moniak is hitting .270 with 20 doubles, eight triples, 24 home runs and 22 walks. He's slugging .518 with an on-base percentage of .306.
• Jordan Beck has 27 doubles, five triples, 15 home runs and 43 walks while batting .262.
• Tyler Freeman has 20 doubles, two triples, two home runs and 34 walks while batting .281.

Giants vs Rockies Head to Head

• 9/3/2025: 10-8 SF (Favorite: Giants, Spread: -1.5, Total: 11.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/2/2025: 7-4 SF (Favorite: Giants, Spread: -1.5, Total: 10.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 9/1/2025: 8-2 SF (Favorite: Giants, Spread: -1.5, Total: 11.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/12/2025: 8-7 COL (Favorite: Giants, Spread: -1.5, Total: 11, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/11/2025: 10-7 SF (Favorite: Giants, Spread: -1.5, Total: 10.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/10/2025: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 11, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 5/4/2025: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -390, Underdog Moneyline: +310)
• 5/3/2025: 6-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/2/2025: 4-0 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/1/2025: 4-3 COL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)

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