Giants vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 10:11 p.m.

The San Francisco Giants will take on the Colorado Rockies in MLB action on Friday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Giants vs Rockies Game Info

• San Francisco Giants (78-81) vs. Colorado Rockies (43-116)
• Date: Friday, September 26, 2025
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and COLR

Giants vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-240) | COL: (+198)
• Spread: SF: -1.5 (-111) | COL: +1.5 (-108)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Giants vs Rockies Probable Starting Pitchers

Probable Pitchers: Trevor McDonald (Giants) - 0-0, 3.38 ERA vs German Marquez (Rockies) - 3-15, 6.49 ERA

The Giants will give the nod to Trevor McDonald and the Rockies will counter with German Marquez (3-15, 6.49 ERA). McDonald helped his team cover the spread in his only opportunity this season as a starter. This will be McDonald's first game as the moneyline favorite this season. The Rockies have a 7-17-0 record against the spread in Marquez's starts. The Rockies are 5-17 in Marquez's 22 starts this season that they were the moneyline underdog.

Giants vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (62.6%)

Giants vs Rockies Moneyline

• Colorado is the underdog, +198 on the moneyline, while San Francisco is a -240 favorite at home.

Giants vs Rockies Spread

• The Rockies are +1.5 on the spread (-108 to cover), and San Francisco is -111 to cover the runline.

Giants vs Rockies Over/Under

• An over/under of 8.5 has been set for Giants-Rockies on Sept. 26, with the over being -105 and the under -115.

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Giants vs Rockies Betting Trends

• The Giants have won in 47, or 51.6%, of the 91 contests they have been named as odds-on favorites in this year.
• This season San Francisco has come away with a win three times in four chances when named as a favorite of at least -240 on the moneyline.
• The Giants and their opponents have gone over the total this season in 76 of their 158 opportunities.
• The Giants have an against the spread mark of 74-84-0 in 158 games with a line this season.
• The Rockies have been the underdog on the moneyline 149 total times this season. They've finished 38-111 in those games.
• When playing as a moneyline underdog with odds of +198 or longer, Colorado has a 13-55 record (winning just 19.1% of its games).
• The Rockies have played in 154 games with a set over/under, and have combined with their opponents to go over the total 68 times (68-81-5).
• The Rockies are 62-92-0 ATS this season.

Giants Player Leaders

• Rafael Devers leads San Francisco in OBP (.370) and total hits (150) this season. He's batting .251 batting average while slugging .474.
• Among qualifying batters in baseball, his batting average ranks 89th, his on-base percentage ranks ninth, and he is 38th in slugging.
• Devers hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .250 with three home runs, three walks and three RBIs.
• Jung Hoo Lee is hitting .260 with 31 doubles, 11 triples, eight home runs and 47 walks, while slugging .401 with an on-base percentage of .323.
• Among qualifying hitters, he is 66th in batting average, 88th in on-base percentage and 102nd in slugging percentage.
• Lee brings a two-game streak with at least one hit into this matchup. During his last five outings he is batting .211 with a double, a walk and an RBI.
• Willy Adames has 131 hits this season and has a slash line of .225/.318/.415.
• Adames brings a two-game hitting streak into this game. In his last five games he is hitting .200 with a double, three walks and two RBIs.
• Heliot Ramos leads San Francisco with a slugging percentage of .400, fueled by 45 extra-base hits.
• Ramos has hit safely in three straight games. In his last five games he is hitting .292 with two home runs and four RBIs.

Rockies Player Leaders

• Hunter Goodman has racked up an on-base percentage of .323, a slugging percentage of .518, and has 147 hits, all club-bests for the Rockies (while batting .278).
• Including all the qualifying players in the majors, his batting average is 27th, his on-base percentage ranks 88th, and he is 13th in slugging.
• Mickey Moniak has 20 doubles, eight triples, 24 home runs and 22 walks while hitting .270. He's slugging .518 with an on-base percentage of .306.
• Jordan Beck is hitting .262 with 27 doubles, five triples, 15 home runs and 43 walks.
• Tyler Freeman has 20 doubles, two triples, two home runs and 34 walks while hitting .281.

Giants vs Rockies Head to Head

• 9/3/2025: 10-8 SF (Favorite: Giants, Spread: -1.5, Total: 11.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/2/2025: 7-4 SF (Favorite: Giants, Spread: -1.5, Total: 10.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 9/1/2025: 8-2 SF (Favorite: Giants, Spread: -1.5, Total: 11.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/12/2025: 8-7 COL (Favorite: Giants, Spread: -1.5, Total: 11, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/11/2025: 10-7 SF (Favorite: Giants, Spread: -1.5, Total: 10.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/10/2025: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 11, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 5/4/2025: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -390, Underdog Moneyline: +310)
• 5/3/2025: 6-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/2/2025: 4-0 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/1/2025: 4-3 COL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)

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