Padres vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 9:12 p.m.

The Milwaukee Brewers will face the San Diego Padres in MLB action on Tuesday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Brewers vs Padres Game Info

• Milwaukee Brewers (95-62) vs. San Diego Padres (86-71)
• Date: Tuesday, September 23, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSWI

Brewers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-118) | SD: (-100)
• Spread: MIL: -1.5 (+136) | SD: +1.5 (-164)
• Total: 8 -- Over: (-110) | Under: (-110)

Brewers vs Padres Probable Starting Pitchers

Probable Pitchers: Bruce Zimmermann (Brewers) - 0-0, 0.00 ERA vs Randy Vasquez (Padres) - 5-7, 3.94 ERA

The probable pitchers are Bruce Zimmermann for the Brewers and Randy Vasquez (5-7) for the Padres. Zimmermann did not pitch as the moneyline favorite in any games last season. The Padres are 15-9-0 ATS in Vasquez's 24 starts that had a set spread. The Padres are 8-8 in Vasquez's 16 starts this season that they were the moneyline underdog.

Brewers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (50.1%)

Brewers vs Padres Moneyline

• Milwaukee is a -118 favorite on the moneyline, while San Diego is a -100 underdog at home.

Brewers vs Padres Spread

• The Padres are +1.5 on the run line against the Brewers. The Padres are -164 to cover, and the Brewers are +136.

Brewers vs Padres Over/Under

• A combined run total of 8 has been set for Brewers-Padres on Sept. 23, with the over at -110 and the under at -110.

Bet on Milwaukee Brewers vs. San Diego Padres on FanDuel today!

Brewers vs Padres Betting Trends

• The Brewers have been chosen as favorites in 92 games this year and have walked away with the win 59 times (64.1%) in those games.
• Milwaukee has a record of 54-27 in contests when oddsmakers favor them by -118 or more on the moneyline.
• The Brewers' games have gone over the total in 78 of their 154 opportunities.
• In 154 games with a line this season, the Brewers have a mark of 85-69-0 against the spread.
• The Padres have been the underdog on the moneyline 66 total times this season. They've finished 32-34 in those games.
• San Diego is 27-30 (winning 47.4% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Padres have combined with opponents to go over the total 68 times this season for a 68-84-3 record against the over/under.
• The Padres have an 83-72-0 record against the spread this season (covering 53.5% of the time).

Brewers Player Leaders

• William Contreras leads Milwaukee in OBP (.359) this season, fueled by 147 hits. He has a .263 batting average and a slugging percentage of .404.
• Among qualifying batters, he is 56th in batting average, his on-base percentage ranks 21st, and he is 93rd in slugging.
• Christian Yelich is batting .266 with 20 doubles, 29 home runs and 63 walks. He's slugging .460 with an on-base percentage of .346.
• He ranks 47th in batting average, 44th in on-base percentage and 47th in slugging in the majors.
• Brice Turang has an OPS of .789, fueled by an OBP of .355 and a team-best slugging percentage of .434 this season.
• Jackson Chourio leads Milwaukee in total hits (144) this season while batting .272 with 58 extra-base hits.

Padres Player Leaders

• Fernando Tatis Jr. is batting .267 with 27 doubles, two triples, 23 home runs and 88 walks. He's slugging .438 with an on-base percentage of .367.
• Including all the qualifying hitters in the majors, his batting average is 43rd, his on-base percentage is 13th, and he is 65th in slugging.
• Tatis enters this matchup on a five-game hitting streak. During his last five outings he is hitting .381 with a home run, two walks and an RBI.
• Manny Machado's 166 hits pace his team. He has a batting average of .274 while slugging .458 with an on-base percentage of .334.
• His batting average is 32nd among all qualified players, his on-base percentage is 65th, and he is 48th in slugging.
• Luis Arraez has a .382 slugging percentage, which leads the Padres.
• Ramon Laureano is batting .282 with 26 doubles, two triples, 24 home runs and 35 walks.

Brewers vs Padres Head to Head

• 9/22/2025: 5-4 SD (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/8/2025: 1-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/7/2025: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/6/2025: 2-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/23/2024: 6-2 MIL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/22/2024: 6-4 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2024: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/20/2024: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 1-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/16/2024: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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