Orioles vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 28

Odds updated as of 2:11 a.m.

MLB action on Tuesday includes the Baltimore Orioles facing the Houston Astros.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Astros Game Info

• Baltimore Orioles (13-15) vs. Houston Astros (11-18)
• Date: Tuesday, April 28, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SCHN

Orioles vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-134) | HOU: (+116)
• Spread: BAL: -1.5 (+146) | HOU: +1.5 (-176)
• Total: 9 -- Over: (-112) | Under: (-108)

Orioles vs Astros Probable Starting Pitchers

Probable Pitchers: Shane Baz (Orioles) - 0-2, 5.08 ERA vs Kai-Wei Teng (Astros) - 1-1, 2.16 ERA

The Orioles will give the nod to Shane Baz (0-2, 5.08 ERA), who is eyeing win No. 1 on the season, and the Astros will counter with Kai-Wei Teng (1-1, 2.16 ERA). Baz's team is 2-3-0 against the spread this season in his starts. Baz's team is 1-1 this season when he starts and they're favored on the moneyline. Last season when Teng pitched his team went 2-5-0 against the spread. Teng and his team lost all six games he pitched when they were moneyline underdogs a season ago.

Orioles vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (51.3%)

Orioles vs Astros Moneyline

• Houston is the underdog, +116 on the moneyline, while Baltimore is a -134 favorite at home.

Orioles vs Astros Spread

• The Orioles are favored by 1.5 runs at home versus the Astros. The Orioles are +146 to cover the spread, while the Astros are -176.

Orioles vs Astros Over/Under

• A total of 9 runs has been set for the Orioles-Astros contest on April 28, with the over available at -112 and the under at -108.

Bet on Baltimore Orioles vs. Houston Astros on FanDuel today!

Orioles vs Astros Betting Trends

• The Orioles have been victorious in 10, or 55.6%, of the 18 contests they have been chosen as favorites in this season.
• Baltimore has a record of 5-4 in contests when oddsmakers favor them by -134 or more on the moneyline.
• The Orioles and their opponents have hit the over in 18 of their 28 games with a total set by oddsmakers this season.
• The Orioles are 12-16-0 against the spread in their 28 games that had a posted line this season.
• The Astros have won 41.7% of the games this season they were the underdog on the moneyline (5-7).
• Houston is 2-6 (winning only 25% of its games) when playing as a moneyline underdog of +116 or longer.
• The Astros have combined with opponents to go over the total 21 times this season for a 21-8-0 record against the over/under.
• The Astros have covered only 37.9% of their games this season, going 11-18-0 ATS.

Orioles Player Leaders

• Taylor Ward has an OPS of .883, fueled by an OBP of .424 to go with a slugging percentage of .459. He has a .312 batting average, as well.
• Among all qualified batters, he is 17th in batting average, his on-base percentage ranks fourth, and he is 54th in slugging.
• Gunnar Henderson has 25 hits, which ranks first among Baltimore batters this season. He's batting .210 with 14 extra-base hits. He's also slugging .487 with an on-base percentage of .280.
• He is 146th in batting average, 157th in on-base percentage and 36th in slugging among qualified batters.
• Jeremiah Jackson has 24 hits this season and has a slash line of .270/.290/.461.
• Leody Taveras has two home runs, 15 RBI and a batting average of .288 this season.

Astros Player Leaders

• Yordan Alvarez has 38 hits with a .465 on-base percentage and a .755 slugging percentage, all club-bests for the Astros. He's batting .358.
• Including all the qualifying hitters in MLB, his batting average puts him first, his on-base percentage is first, and he is first in slugging.
• Alvarez heads into this game on a 12-game hitting streak. In his last 10 games he is hitting .395 with three doubles, four home runs, two walks and nine RBIs.
• Christian Walker is hitting .291 with eight doubles, seven home runs and 13 walks. He's slugging .573 with an on-base percentage of .373.
• Including all qualified players, his batting average places him 31st, his on-base percentage is 31st, and he is seventh in slugging.
• Carlos Correa has seven doubles, two home runs and 15 walks while batting .281.
• Jose Altuve is batting .260 with seven doubles, three home runs and 16 walks.

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