Ole Miss vs South Carolina Prediction, Odds, Picks, Best Bets for Week 10 2025

In college football action on Saturday, the Ole Miss Rebels play the South Carolina Gamecocks.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Ole Miss vs South Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ole Miss: (-481) | South Carolina: (+370)
• Spread: Ole Miss: -12.5 (-106) | South Carolina: +12.5 (-114)
• Total: 55.5 -- Over: (-110) | Under: (-110)

Ole Miss vs South Carolina Betting Trends

• Ole Miss is 5-3-0 against the spread this year.
• Ole Miss has won twice ATS (2-1) as a 12.5-point or bigger favorite this season.
• There have been five Ole Miss games (of eight) that hit the over this year.
• South Carolina has beaten the spread four times in eight games.
• South Carolina is unbeaten ATS (1-0) as a 12.5-point underdog or more this year.
• South Carolina has played eight games this season, and three of them have hit the over.

Ole Miss vs South Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Rebels win (72.5%)

Ole Miss vs South Carolina Point Spread

Ole Miss is favored by 12.5 points against South Carolina. Ole Miss is -106 to cover the spread, while South Carolina is -114.

Ole Miss vs South Carolina Over/Under

A total of 55.5 points has been set for the Ole Miss-South Carolina game on Nov. 1, with the over available at -110 and the under at -110.

Ole Miss vs South Carolina Moneyline

Ole Miss is the favorite, -481 on the moneyline, while South Carolina is a +370 underdog.

Ole Miss vs. South Carolina Points Insights

Ole Miss vs. South Carolina Game Info

• Game day: Saturday, November 1, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Oxford, Mississippi
• Stadium: Vaught-Hemingway Stadium

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Check out even more in-depth Ole Miss vs. South Carolina analysis on FanDuel Research.