Ole Miss vs Kentucky Prediction, Odds, Picks, Best Bets for Week 2 2025

The Saturday schedule in college football includes a matchup between the Ole Miss Rebels and the Kentucky Wildcats.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Ole Miss vs Kentucky Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ole Miss: (-319) | Kentucky: (+255)
• Spread: Ole Miss: -9.5 (-105) | Kentucky: +9.5 (-115)
• Total: 50.5 -- Over: (-108) | Under: (-112)

Ole Miss vs Kentucky Betting Trends

• Ole Miss has posted one win against the spread this year.
• Ole Miss is unbeaten ATS (1-0) as a 9.5-point favorite or greater this season.
• One of one Ole Miss games have gone over the point total this year.
• Kentucky has no wins against the spread this year.
• Kentucky and its opponent have yet to go over the total this season.

Ole Miss vs Kentucky Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Rebels win (85.2%)

Ole Miss vs Kentucky Point Spread

Ole Miss is favored by 9.5 points (-105 to cover) in this matchup. Kentucky, the underdog, is -115.

Ole Miss vs Kentucky Over/Under

The Ole Miss-Kentucky game on Sept. 6 has been given an over/under of 50.5 points. The over is -108 and the under is -112.

Ole Miss vs Kentucky Moneyline

Looking at the moneyline for Kentucky-Ole Miss, Kentucky is the underdog at +255, and Ole Miss is -319.

Ole Miss vs. Kentucky Points Insights

• The Rebels had an average implied point total of 39.2 last season, which is 9.2 points higher than their implied total in Saturday's game (30).
• The average implied point total last season for the Wildcats (31.3) is 10.3 more points than the team's implied total in this matchup (21).

Ole Miss vs. Kentucky Game Info

• Game day: Saturday, September 6, 2025
• Game time: 3:30 p.m. ET
• TV channel: ABC
• Location: Lexington, Kentucky
• Stadium: Kroger Field

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Check out even more in-depth Ole Miss vs. Kentucky analysis on FanDuel Research.