Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 6:19 p.m.

The Saturday slate in MLB includes a matchup between the Milwaukee Brewers and the Pittsburgh Pirates.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Pirates Game Info

• Milwaukee Brewers (87-55) vs. Pittsburgh Pirates (64-78)
• Date: Saturday, September 6, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSWI

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-144) | PIT: (+122)
• Spread: MIL: -1.5 (+110) | PIT: +1.5 (-132)
• Total: 8 -- Over: (-104) | Under: (-118)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Brandon Woodruff (Brewers) - 5-2, 3.69 ERA vs Mitch Keller (Pirates) - 6-13, 4.21 ERA

The Brewers will give the nod to Brandon Woodruff (5-2, 3.69 ERA), who is eyeing win No. 6 on the season, and the Pirates will turn to Mitch Keller (6-13, 4.21 ERA). When Woodruff starts, his team is 5-5-0 against the spread this season. Woodruff's team is 6-2 this season when he starts and they are the moneyline favorite. The Pirates have a 16-11-0 ATS record in Keller's 27 starts that had a set spread. The Pirates have a 9-12 record in Keller's 21 starts this season when they were the underdog on the moneyline.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (53.4%)

Brewers vs Pirates Moneyline

• The Brewers vs Pirates moneyline has Milwaukee as a -144 favorite, while Pittsburgh is a +122 underdog at home.

Brewers vs Pirates Spread

• The Pirates are +1.5 on the run line against the Brewers. The Pirates are -132 to cover, and the Brewers are +110.

Brewers vs Pirates Over/Under

• Brewers versus Pirates on Sept. 6 has an over/under of 8 runs, with the odds on the over -104 and the under set at -118.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have been chosen as favorites in 78 games this year and have walked away with the win 51 times (65.4%) in those games.
• Milwaukee has a record of 25-9 in contests when bookmakers favor them by -144 or more on the moneyline.
• The Brewers and their opponents have gone over the total this season in 69 of their 139 opportunities.
• In 139 games with a line this season, the Brewers have a mark of 79-60-0 against the spread.
• The Pirates have gone 41-53 in games they were listed as the moneyline underdog (winning 43.6% of those games).
• Pittsburgh has a record of 20-36 in games it has played as a moneyline underdog with odds of +122 or longer (35.7%).
• The Pirates have combined with opponents to go over the total 53 times this season for a 53-75-6 record against the over/under.
• The Pirates have covered 55.2% of their games this season, going 74-60-0 ATS.

Brewers Player Leaders

• William Contreras is hitting .263 with 26 doubles, 17 home runs and 77 walks. He has an on-base percentage of .358 while slugging .411.
• He ranks 63rd in batting average, 24th in on-base percentage, and 94th in slugging among all qualifying hitters in the majors.
• Contreras hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .381 with a double, a home run, two walks and three RBIs.
• Brice Turang has hit 17 homers this season while driving in 71 runs. He's batting .292 this season and slugging .448 with an on-base percentage of .358.
• Among all qualifying players, he is 14th in batting average, 24th in on-base percentage and 63rd in slugging percentage.
• Christian Yelich is batting .268 with a .464 slugging percentage and 92 RBI this year.
• Jackson Chourio leads Milwaukee with 129 hits, batting .276 this season with 53 extra-base hits.

Pirates Player Leaders

• Bryan Reynolds has put up a team-high slugging percentage (.408) and paces the Pirates in hits (127). He's batting .245 and with an on-base percentage of .313.
• Including all qualifying hitters, he ranks 106th in batting average, while his on-base percentage is 110th and he is 98th in slugging.
• Oneil Cruz is hitting .205 with 17 doubles, two triples, 19 home runs and 59 walks. He's slugging .390 with an on-base percentage of .305.
• His batting average is 151st among all qualified players, his on-base percentage ranks 123rd, and he is 120th in slugging.
• Andrew McCutchen a has .339 on-base percentage to lead the Pirates.
• Tommy Pham is hitting .264 with 17 doubles, a triple, eight home runs and 39 walks.

Brewers vs Pirates Head to Head

• 9/5/2025: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/13/2025: 12-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/12/2025: 14-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/11/2025: 7-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/25/2025: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/24/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/23/2025: 5-4 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/25/2025: 6-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/24/2025: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2025: 6-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)

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