Notre Dame vs Pittsburgh Prediction, Odds, Picks, Best Bets for Week 12 2025

The Notre Dame Fighting Irish will face the Pittsburgh Panthers in college football action on Saturday.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Notre Dame vs Pittsburgh Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-490) | Pittsburgh: (+380)
• Spread: Notre Dame: -11.5 (-114) | Pittsburgh: +11.5 (-106)
• Total: 55.5 -- Over: (-108) | Under: (-112)

Notre Dame vs Pittsburgh Betting Trends

• Notre Dame has covered the spread four times in nine games.
• For the year, Notre Dame is 3-2 as 11.5-point or better favorites.
• There have been five Notre Dame games (of nine) that went over the total this season.
• Pittsburgh has seven wins in nine contests against the spread this season.
• Pittsburgh has played nine games this season, and seven of them have hit the over.

Notre Dame vs Pittsburgh Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (74.9%)

Notre Dame vs Pittsburgh Point Spread

Pittsburgh is a 11.5-point underdog against Notre Dame. Pittsburgh is -106 to cover the spread, and Notre Dame is -114.

Notre Dame vs Pittsburgh Over/Under

The over/under for the Notre Dame versus Pittsburgh game on Nov. 15 has been set at 55.5, with -108 odds on the over and -112 odds on the under.

Notre Dame vs Pittsburgh Moneyline

Pittsburgh is the underdog, +380 on the moneyline, while Notre Dame is a -490 favorite.

Notre Dame vs. Pittsburgh Points Insights

Notre Dame vs. Pittsburgh Game Info

• Game day: Saturday, November 15, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: Pittsburgh, Pennsylvania
• Stadium: Acrisure Stadium

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Check out even more in-depth Notre Dame vs. Pittsburgh analysis on FanDuel Research.