Nationals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 2:15 p.m.

MLB action on Sunday includes the Washington Nationals taking on the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Nationals vs White Sox Game Info

• Washington Nationals (66-95) vs. Chicago White Sox (59-102)
• Date: Sunday, September 28, 2025
• Time: 3:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CHSN

Nationals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-116) | CHW: (-102)
• Spread: WSH: +1.5 (-200) | CHW: -1.5 (+164)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Nationals vs White Sox Probable Starting Pitchers

Probable Pitchers: Brad Lord (Nationals) - 5-9, 4.12 ERA vs Shane Smith (White Sox) - 6-8, 3.98 ERA

The Nationals will give the nod to Brad Lord (5-9, 4.12 ERA), who is eyeing win No. 6 on the season, and the White Sox will turn to Shane Smith (6-8, 3.98 ERA). Lord and his team are 10-7-0 ATS this season when he starts. Lord's team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox are 16-12-0 ATS in Smith's 28 starts that had a set spread. The White Sox are 8-17 in Smith's 25 starts this season that they were the moneyline underdog.

Nationals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (55.7%)

Nationals vs White Sox Moneyline

• Looking at the moneyline for Nationals-White Sox, Washington is the favorite at -116, and Chicago is -102 playing on the road.

Nationals vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Nationals. The White Sox are +164 to cover, while the Nationals are -200 to cover as a 1.5-run underdog on the runline.

Nationals vs White Sox Over/Under

• An over/under of 8.5 has been set for Nationals-White Sox on Sept. 28, with the over being -102 and the under -120.

Bet on Washington Nationals vs. Chicago White Sox on FanDuel today!

Nationals vs White Sox Betting Trends

• The Nationals have been chosen as favorites in 20 games this year and have walked away with the win seven times (35%) in those games.
• This year Washington has won three of 13 games when listed as at least -116 on the moneyline.
• Contests with the Nationals have gone over the total set by bookmakers in 83 of 155 chances this season.
• The Nationals have posted a record of 77-78-0 against the spread this season.
• The White Sox have gone 55-97 in games they were the underdog on the moneyline (winning 36.2% of those games).
• Chicago is 54-94 (winning just 36.5% of its games) when it has played as a moneyline underdog of -102 or longer.
• The White Sox have had an over/under set by bookmakers 156 times, and have combined with opponents to go over the total in 72 of those games (72-76-8).
• The White Sox have collected an 88-68-0 record ATS this season.

Nationals Player Leaders

• James Wood leads Washington in OBP (.351), slugging percentage (.477) and total hits (153) this season. He has a .257 batting average.
• Among all qualified hitters in baseball, he is 74th in batting average, 36th in on-base percentage, and 31st in slugging.
• C.J. Abrams is batting .258 with 35 doubles, five triples, 19 home runs and 37 walks. He's slugging .435 with an on-base percentage of .317.
• He is 71st in batting average, 98th in on-base percentage and 70th in slugging among qualifying hitters.
• Luis Garcia has 123 hits this season and has a slash line of .254/.291/.414.
• Josh Bell is batting .240 with a .328 OBP and 63 RBI for Washington this season.
• Bell takes a three-game hitting streak into this game. During his last five outings he is batting .500 with three doubles, two home runs, two walks and two RBIs.

White Sox Player Leaders

• Miguel Vargas is hitting .234 with 32 doubles, two triples, 15 home runs and 55 walks. He's slugging .396 with an on-base percentage of .316.
• Including all qualified players in the majors, he is 125th in batting average, 101st in on-base percentage and 108th in slugging percentage.
• Vargas heads into this game on an eight-game hitting streak. During his last 10 games he is batting .270 with a double, a home run, five walks and five RBIs.
• Lenyn Sosa's 135 hits and .432 slugging percentage are both team-highs. He has a batting average of .263 with an on-base percentage of .291.
• Including all qualified players, he is 59th in batting average, 133rd in on-base percentage and 73rd in slugging percentage.
• Chase Meidroth has accumulated an on-base percentage of .332, a team-high for the White Sox.
• Colson Montgomery is batting .239 with nine doubles, a triple, 21 home runs and 24 walks.

Nationals vs White Sox Head to Head

• 9/27/2025: 6-5 WSH (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/26/2025: 10-9 CHW (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/15/2024: 2-0 CHW (Favorite: White Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/14/2024: 4-0 CHW (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2024: 6-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/20/2023: 13-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 9/19/2023: 4-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/18/2023: 6-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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