Nationals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 11:12 p.m.

Sunday's slate in the MLB includes a matchup between the Washington Nationals and the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Nationals vs White Sox Game Info

• Washington Nationals (66-95) vs. Chicago White Sox (59-102)
• Date: Sunday, September 28, 2025
• Time: 3:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CHSN

Nationals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-116) | CHW: (-102)
• Spread: WSH: +1.5 (-200) | CHW: -1.5 (+164)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Nationals vs White Sox Probable Starting Pitchers

Probable Pitchers: Brad Lord (Nationals) - 5-9, 4.12 ERA vs Shane Smith (White Sox) - 6-8, 3.98 ERA

The probable pitchers are Brad Lord (5-9) for the Nationals and Shane Smith (6-8) for the White Sox. Lord's team is 10-7-0 against the spread in his starts this season. Lord's team is 1-1 this season when he starts and they're favored on the moneyline. When Smith starts, the White Sox are 16-12-0 against the spread. The White Sox have been the moneyline underdog in 25 of Smith's starts this season, and they went 8-17 in those games.

Nationals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (51.4%)

Nationals vs White Sox Moneyline

• Chicago is the underdog, -102 on the moneyline, while Washington is a -116 favorite at home.

Nationals vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Nationals. The White Sox are +164 to cover, while the Nationals are -200 to cover as a 1.5-run underdog on the runline.

Nationals vs White Sox Over/Under

• The over/under for Nationals-White Sox on Sept. 28 is 8.5. The over is -115, and the under is -105.

Bet on Washington Nationals vs. Chicago White Sox on FanDuel today!

Nationals vs White Sox Betting Trends

• The Nationals have been victorious in seven, or 35%, of the 20 contests they have been chosen as favorites in this season.
• Washington has a record of 3-10 in contests when sportsbooks favor them by -116 or more on the moneyline.
• The Nationals and their opponents have hit the over in 83 of their 155 games with a total set by oddsmakers this season.
• The Nationals are 77-78-0 against the spread in their 155 games that had a posted line this season.
• The White Sox have gone 55-97 in games they were the underdog on the moneyline (winning 36.2% of those games).
• Chicago is 54-94 (winning just 36.5% of its games) when it has played as a moneyline underdog of -102 or longer.
• The White Sox have played in 156 games with an over/under set, and have combined with their opponents to go over the total 72 times (72-76-8).
• The White Sox have covered 56.4% of their games this season, going 88-68-0 ATS.

Nationals Player Leaders

• James Wood leads Washington with 153 hits and an OBP of .351, plus a team-best slugging percentage of .477. He's batting .257.
• He ranks 75th in batting average, 37th in on-base percentage, and 32nd in slugging among qualifying hitters in baseball.
• C.J. Abrams is batting .258 with 35 doubles, five triples, 19 home runs and 37 walks. He's slugging .435 with an on-base percentage of .317.
• Among qualified hitters, he ranks 72nd in batting average, 98th in on-base percentage and 71st in slugging percentage.
• Luis Garcia has collected 123 base hits, an OBP of .291 and a slugging percentage of .414 this season.
• Josh Bell has been key for Washington with 112 hits, an OBP of .328 plus a slugging percentage of .423.
• Bell has safely hit in three games in a row. In his last five games he is batting .500 with three doubles, two home runs, two walks and two RBIs.

White Sox Player Leaders

• Miguel Vargas is hitting .234 with 32 doubles, two triples, 15 home runs and 55 walks. He's slugging .396 with an on-base percentage of .316.
• Including all qualifying players in the majors, he ranks 126th in batting average, 100th in on-base percentage and 108th in slugging percentage.
• Vargas brings an eight-game hitting streak into this matchup. During his last 10 outings he is batting .270 with a double, a home run, five walks and five RBIs.
• Lenyn Sosa leads his team with 135 hits and has a club-leading .432 slugging percentage. He has a batting average of .263 with an on-base percentage of .291.
• He is 59th in batting average, 132nd in on-base percentage and 74th in slugging percentage in the big leagues.
• Chase Meidroth a has .332 on-base percentage to pace the White Sox.
• Colson Montgomery is batting .239 with nine doubles, a triple, 21 home runs and 24 walks.

Nationals vs White Sox Head to Head

• 9/27/2025: 6-5 WSH (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/26/2025: 10-9 CHW (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/15/2024: 2-0 CHW (Favorite: White Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/14/2024: 4-0 CHW (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2024: 6-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/20/2023: 13-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 9/19/2023: 4-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/18/2023: 6-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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