Nationals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 3:12 p.m.

The Washington Nationals versus the Chicago White Sox is on the MLB schedule for Saturday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Nationals vs White Sox Game Info

• Washington Nationals (65-95) vs. Chicago White Sox (59-101)
• Date: Saturday, September 27, 2025
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CHSN

Nationals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-112) | CHW: (-104)
• Spread: WSH: +1.5 (-188) | CHW: -1.5 (+155)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Nationals vs White Sox Probable Starting Pitchers

Probable Pitchers: Jake Irvin (Nationals) - 9-13, 5.69 ERA vs Sean Burke (White Sox) - 4-11, 4.29 ERA

The Nationals will give the nod to Jake Irvin (9-13) versus the White Sox and Sean Burke (4-11). Irvin and his team are 16-15-0 ATS this season when he starts. Irvin's team lost his only start as a favorite this season. The White Sox have a 13-9-0 record against the spread in Burke's starts. The White Sox have been the underdog on the moneyline in 22 of Burke's starts this season, and they went 9-13 in those matchups.

Nationals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (52%)

Nationals vs White Sox Moneyline

• The Nationals vs White Sox moneyline has Washington as a -112 favorite, while Chicago is a -104 underdog on the road.

Nationals vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Nationals. The White Sox are +155 to cover, while the Nationals are -188 to cover as a 1.5-run underdog on the runline.

Nationals vs White Sox Over/Under

• The over/under for Nationals-White Sox on Sept. 27 is 8.5. The over is -122, and the under is -100.

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Nationals vs White Sox Betting Trends

• The Nationals have won in six, or 31.6%, of the 19 contests they have been named as odds-on favorites in this year.
• This season Washington has come away with a win five times in 17 chances when named as a favorite of at least -112 on the moneyline.
• The Nationals and their opponents have hit the over in 82 of their 154 games with a total set by oddsmakers this season.
• The Nationals are 76-78-0 against the spread in their 154 games that had a posted line this season.
• The White Sox have won 36.4% of the games this season they were the moneyline underdog (55-96).
• Chicago has gone 54-95 in games it has played as a moneyline underdog with odds of -104 or longer (36.2%).
• In the 155 games bookmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 71 times (71-76-8).
• The White Sox have covered 56.8% of their games this season, going 88-67-0 ATS.

Nationals Player Leaders

• C.J. Abrams is hitting .260 with 35 doubles, five triples, 19 home runs and 37 walks. He has an on-base percentage of .319 and a slugging percentage of .439.
• He is 68th in batting average, 98th in on-base percentage, and 67th in slugging among all qualifying batters in MLB.
• Abrams will look for his fourth straight game with a hit in this matchup. During his last five outings he is batting .182 with a double, a home run, a walk and two RBIs.
• James Wood leads Washington in OBP (.349), slugging percentage (.471) and total hits (150) this season. He's batting .254.
• Among qualifiers, he is 87th in batting average, 42nd in on-base percentage and 40th in slugging percentage.
• Luis Garcia has 123 hits this season and has a slash line of .255/.291/.417.
• Josh Bell has been key for Washington with 110 hits, an OBP of .324 plus a slugging percentage of .417.
• Bell has hit safely in two games in a row. In his last five games he is hitting .429 with a double, two home runs, a walk and two RBIs.

White Sox Player Leaders

• Miguel Vargas has 32 doubles, two triples, 15 home runs and 54 walks while batting .233. He's slugging .396 with an on-base percentage of .314.
• Including all qualifying hitters in the big leagues, he is 129th in batting average, 106th in on-base percentage and 109th in slugging percentage.
• Vargas takes a seven-game hitting streak into this game. During his last 10 games he is hitting .257 with a double, a home run, four walks and five RBIs.
• Lenyn Sosa has collected 134 hits while slugging .433. Both are team-highs. He has a batting average of .263 with an on-base percentage of .292.
• He is 58th in batting average, 132nd in on-base percentage and 73rd in slugging percentage in the big leagues.
• Chase Meidroth has an on-base percentage of .333, a team-best for the White Sox.
• Colson Montgomery has eight doubles, a triple, 20 home runs and 24 walks while hitting .231.

Nationals vs White Sox Head to Head

• 9/26/2025: 10-9 CHW (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/15/2024: 2-0 CHW (Favorite: White Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/14/2024: 4-0 CHW (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2024: 6-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/20/2023: 13-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 9/19/2023: 4-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/18/2023: 6-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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