Nationals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 2:12 a.m.

In MLB action on Saturday, the Washington Nationals take on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this game.

Nationals vs White Sox Game Info

• Washington Nationals (65-95) vs. Chicago White Sox (59-101)
• Date: Saturday, September 27, 2025
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CHSN

Nationals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-120) | CHW: (+102)
• Spread: WSH: +1.5 (-196) | CHW: -1.5 (+162)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Nationals vs White Sox Probable Starting Pitchers

Probable Pitchers: Jake Irvin (Nationals) - 9-13, 5.69 ERA vs Sean Burke (White Sox) - 4-11, 4.29 ERA

The Nationals will give the nod to Jake Irvin (9-13, 5.69 ERA), who is eyeing win No. 10 on the season, and the White Sox will turn to Sean Burke (4-11, 4.29 ERA). Irvin's team is 16-15-0 against the spread this season in his starts. Irvin's team lost his only start as a favorite this season. The White Sox have a 13-9-0 record against the spread in Burke's starts. The White Sox have a 9-13 record in Burke's 22 starts this season when they were the moneyline underdog.

Nationals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (51.8%)

Nationals vs White Sox Moneyline

• The moneyline numbers for Nationals vs. White Sox reveal Washington as the favorite (-120) and Chicago as the underdog (+102) on the road.

Nationals vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Nationals. The White Sox are +162 to cover, while the Nationals are -196 to cover as a 1.5-run underdog on the runline.

Nationals vs White Sox Over/Under

• An over/under of 8.5 has been set for Nationals-White Sox on Sept. 27, with the over being -110 and the under -110.

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Nationals vs White Sox Betting Trends

• The Nationals have been chosen as favorites in 19 games this year and have walked away with the win six times (31.6%) in those games.
• This season Washington has been victorious two times in 10 chances when named as a favorite of at least -120 on the moneyline.
• The Nationals and their opponents have gone over the total this season in 82 of their 154 opportunities.
• The Nationals are 76-78-0 against the spread in their 154 games with a line set by sportsbooks this season.
• The White Sox have been the moneyline underdog 151 total times this season. They've gone 55-96 in those games.
• Chicago has gone 53-92 in games it has played as a moneyline underdog with odds of +102 or longer (36.6%).
• The White Sox have had an over/under set by bookmakers 155 times, and have combined with opponents to go over the total in 71 of those games (71-76-8).
• The White Sox are 88-67-0 against the spread this season.

Nationals Player Leaders

• C.J. Abrams is batting .260 with 35 doubles, five triples, 19 home runs and 37 walks. He has an on-base percentage of .319 while slugging .439.
• Among all qualified hitters in the majors, he ranks 68th in batting average, 98th in on-base percentage, and 67th in slugging.
• Abrams will look for his fourth straight game with a hit in this matchup. During his last five outings he is hitting .182 with a double, a home run, a walk and two RBIs.
• James Wood leads Washington in OBP (.349), slugging percentage (.471) and total hits (150) this season. He's batting .254.
• Among qualified hitters, he ranks 87th in batting average, 42nd in on-base percentage and 40th in slugging percentage.
• Luis Garcia has collected 123 base hits, an OBP of .291 and a slugging percentage of .417 this season.
• Josh Bell has been key for Washington with 110 hits, an OBP of .324 plus a slugging percentage of .417.
• Bell enters this game on a two-game hitting streak. During his last five outings he is hitting .429 with a double, two home runs, a walk and two RBIs.

White Sox Player Leaders

• Miguel Vargas has 32 doubles, two triples, 15 home runs and 54 walks while hitting .233. He's slugging .396 with an on-base percentage of .314.
• Including all qualifying hitters, he ranks 129th in batting average, while his on-base percentage is 106th and he is 109th in slugging.
• Vargas enters this game on a seven-game hitting streak. During his last 10 outings he is hitting .257 with a double, a home run, four walks and five RBIs.
• Lenyn Sosa's 134 hits and .433 slugging percentage both lead his team. He has a batting average of .263 with an on-base percentage of .292.
• Including all qualifying players, he ranks 58th in batting average, 132nd in on-base percentage and 73rd in slugging percentage.
• Chase Meidroth has put up an on-base percentage of .333, a team-high for the White Sox.
• Colson Montgomery has eight doubles, a triple, 20 home runs and 24 walks while batting .231.

Nationals vs White Sox Head to Head

• 9/26/2025: 10-9 CHW (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/15/2024: 2-0 CHW (Favorite: White Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/14/2024: 4-0 CHW (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2024: 6-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/20/2023: 13-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 9/19/2023: 4-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/18/2023: 6-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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