Nationals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 6:14 p.m.

On Friday in MLB, the Washington Nationals are up against the Chicago White Sox.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Nationals vs White Sox Game Info

• Washington Nationals (65-94) vs. Chicago White Sox (58-101)
• Date: Friday, September 26, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CHSN

Nationals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-130) | CHW: (+110)
• Spread: WSH: -1.5 (+158) | CHW: +1.5 (-192)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Nationals vs White Sox Probable Starting Pitchers

Probable Pitchers: Cade Cavalli (Nationals) - 3-1, 4.23 ERA vs Yoendrys Gomez (White Sox) - 3-3, 4.92 ERA

The Nationals will give the nod to Cade Cavalli (3-1, 4.23 ERA), who is eyeing win No. 4 on the season, and the White Sox will counter with Yoendrys Gomez (3-3, 4.92 ERA). Cavalli and his team have a record of 7-2-0 against the spread when he starts. Cavalli's team won his only start as a favorite this season. The White Sox have gone 6-2-0 ATS in Gomez's eight starts that had a set spread. The White Sox are 4-4 in Gomez's eight starts this season that they were the moneyline underdog.

Nationals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (55.9%)

Nationals vs White Sox Moneyline

• Looking at the moneyline for White Sox-Nationals, Chicago is the underdog at +110, and Washington is -130 playing at home.

Nationals vs White Sox Spread

• The Nationals are favored by 1.5 runs at home against the White Sox. The Nationals are +158 to cover the spread, while the White Sox are -192.

Nationals vs White Sox Over/Under

• An over/under of 8.5 has been set for Nationals-White Sox on Sept. 26, with the over being -122 and the under -100.

Bet on Washington Nationals vs. Chicago White Sox on FanDuel today!

Nationals vs White Sox Betting Trends

• The Nationals have been chosen as favorites in 18 games this year and have walked away with the win six times (33.3%) in those games.
• Washington has a record of 2-7 in contests when sportsbooks favor them by -130 or more on the moneyline.
• The Nationals and their opponents have gone over the total this season in 81 of their 153 opportunities.
• The Nationals have an against the spread mark of 76-77-0 in 153 games with a line this season.
• The White Sox have been the underdog on the moneyline 150 total times this season. They've finished 54-96 in those games.
• Chicago has gone 48-88 when playing as a moneyline underdog with odds of +110 or longer (35.3%).
• The White Sox have played in 154 games with an over/under set, and have combined with opponents to go over the total 70 times (70-76-8).
• The White Sox have an 87-67-0 record against the spread this season (covering 56.5% of the time).

Nationals Player Leaders

• C.J. Abrams is batting .259 with 35 doubles, five triples, 18 home runs and 36 walks. He has an on-base percentage of .317 and a slugging percentage of .433.
• Among the qualified hitters in MLB, his batting average ranks 71st, his on-base percentage ranks 98th, and he is 73rd in slugging.
• Abrams hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .182 with two doubles, a home run and four RBIs.
• James Wood has 150 hits and an OBP of .352 to go with a slugging percentage of .475. All three of those stats are tops among Washington hitters this season. He's batting .256.
• He ranks 82nd in batting average, 36th in on-base percentage and 36th in slugging among qualifying batters.
• Wood enters this matchup looking to extend his three-game hit streak. In his last five games he is batting .278 with a double, three home runs, three walks and three RBIs.
• Luis Garcia is batting .251 with a .395 slugging percentage and 62 RBI this year.
• Josh Bell is batting .235 with a .323 OBP and 62 RBI for Washington this season.

White Sox Player Leaders

• Miguel Vargas has racked up a team-high .314 on-base percentage. He's batting .232 and slugging .396.
• Including all qualifying players, he ranks 129th in batting average, while his on-base percentage is 105th and he is 106th in slugging.
• Vargas brings a six-game hitting streak into this matchup. During his last 10 games he is hitting .265 with two doubles, a home run, four walks and five RBIs.
• Lenyn Sosa has collected 131 hits while slugging .423. Both are team-highs. He has a batting average of .259 with an on-base percentage of .288.
• He ranks 71st in batting average, 135th in on-base percentage and 77th in slugging percentage in MLB.
• Chase Meidroth is batting .257 with 15 doubles, five home runs and 45 walks.
• Colson Montgomery is batting .231 with eight doubles, a triple, 19 home runs and 24 walks.

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