Missouri vs Louisiana Prediction, Odds, Picks, Best Bets for Week 3 2025

In college football action on Saturday, the Missouri Tigers take on the Louisiana Ragin' Cajuns.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Missouri vs Louisiana Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Missouri: (-7143) | Louisiana: (+2000)
• Spread: Missouri: -27.5 (-105) | Louisiana: +27.5 (-115)
• Total: 47.5 -- Over: (-110) | Under: (-110)

Missouri vs Louisiana Betting Trends

• Missouri has two wins against the spread this season.
• Missouri has covered every time (1-0) as a 27.5-point favorite or greater this season.
• Missouri has had two games (out of two) hit the over this season.
• Louisiana has not won a game against the spread this season.
• No Louisiana game has hit the over this year.

Missouri vs Louisiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (86.3%)

Missouri vs Louisiana Point Spread

Louisiana is the underdog by 27.5 points against Missouri. Louisiana is -105 to cover the spread, and Missouri is -115.

Missouri vs Louisiana Over/Under

A combined point total of 47.5 has been set for Missouri-Louisiana on Sept. 13, with the over at -110 and the under at -110.

Missouri vs Louisiana Moneyline

Missouri is the favorite, -7143 on the moneyline, while Louisiana is a +2000 underdog.

Missouri vs. Louisiana Points Insights

Missouri vs. Louisiana Game Info

• Game day: Saturday, September 13, 2025
• Game time: 1 p.m. ET
• TV channel: SEC Network+
• Location: Columbia, Missouri
• Stadium: Memorial Stadium/Faurot Field

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Missouri vs. Louisiana analysis on FanDuel Research.