Mississippi State vs Northern Illinois Prediction, Odds, Picks, Best Bets for Week 4 2025

The college football schedule on Saturday includes the Mississippi State Bulldogs taking on the Northern Illinois Huskies.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Mississippi State vs Northern Illinois Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Mississippi State: (-3030) | Northern Illinois: (+1200)
• Spread: Mississippi State: -22.5 (-115) | Northern Illinois: +22.5 (-105)
• Total: 48.5 -- Over: (-110) | Under: (-110)

Mississippi State vs Northern Illinois Betting Trends

• Mississippi State's record against the spread is 3-0-0.
• Mississippi State is unbeaten ATS (1-0) as a 22.5-point favorite or greater this season.
• Mississippi State has had one game (of three) go over the total this year.
• Northern Illinois has but one win versus the spread this season.
• Not one of Northern Illinois' two games has gone over the point total in 2025.

Mississippi State vs Northern Illinois Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulldogs win (82.6%)

Mississippi State vs Northern Illinois Point Spread

Northern Illinois is an underdog by 22.5 points versus Mississippi State. Northern Illinois is -105 to cover the spread, and Mississippi State is -115.

Mississippi State vs Northern Illinois Over/Under

A total of 48.5 points has been set for the Mississippi State-Northern Illinois game on Sept. 20, with the over available at -110 and the under at -110.

Mississippi State vs Northern Illinois Moneyline

Northern Illinois is the underdog, +1200 on the moneyline, while Mississippi State is a -3030 favorite.

Mississippi State vs. Northern Illinois Points Insights

Mississippi State vs. Northern Illinois Game Info

• Game day: Saturday, September 20, 2025
• Game time: 4:15 p.m. ET
• TV channel: SEC Network
• Location: Starkville, Mississippi
• Stadium: Davis Wade Stadium at Scott Field

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Check out even more in-depth Mississippi State vs. Northern Illinois analysis on FanDuel Research.