Michigan vs Purdue Prediction, Odds, Picks, Best Bets for Week 10 2025

College football's Saturday slate includes the Michigan Wolverines facing the Purdue Boilermakers.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Michigan vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Michigan: (-2222) | Purdue: (+1100)
• Spread: Michigan: -21.5 (-105) | Purdue: +21.5 (-115)
• Total: 48.5 -- Over: (-118) | Under: (-104)

Michigan vs Purdue Betting Trends

• Michigan's record against the spread is 3-5-0.
• As a 21.5-point or greater favorite, Michigan has one win ATS (1-1) this season.
• This year, four of Michigan's eight games have gone over the point total.
• Purdue's record against the spread in 2025 is 3-5-0.
• Purdue doesn't have a win ATS (0-1) as a 21.5-point underdog or greater this year.
• A pair of Purdue eight games in 2025 have hit the over.

Michigan vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Wolverines win (95.5%)

Michigan vs Purdue Point Spread

Purdue is an underdog by 21.5 points versus Michigan. Purdue is -115 to cover the spread, and Michigan is -105.

Michigan vs Purdue Over/Under

A combined point total of 48.5 has been set for Michigan-Purdue on Nov. 1, with the over at -118 and the under at -104.

Michigan vs Purdue Moneyline

Michigan is a -2222 favorite on the moneyline, while Purdue is a +1100 underdog.

Michigan vs. Purdue Points Insights

Michigan vs. Purdue Game Info

• Game day: Saturday, November 1, 2025
• Game time: 7 p.m. ET
• TV channel: BTN
• Location: Ann Arbor, Michigan
• Stadium: Michigan Stadium

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